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Journals / The Turkish Journal of Ear Nose and Throat / 2018 / Cilt: 28 - Sayı: 1

The effect of experimental hypothyroidism on nasal mucosa

Gökhan CESUR
Yeşim BAŞAL
Ceren GÜNEL
Aylin ERYILMAZ
Nuket ÖZKAVRUK ELİYATKIN
Pages
21–25
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Thyroid hormone receptor (TR-a, TR-b) status was assessed by immunohistochemical staining.Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant (p

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Objective & Hypothesis:Objectives: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormonereceptors in an experimental postnatal hypothyroidism model.Materials and Methods: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospectiverandomized study and were divided into two groups: Group 1 (n=11, methimazole, MMI -induced hypothyroidism group) given MMIwater,and Group 2 (n=10, control group), normal tap water.
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Key Findings & Data:When the offspring reached 90 days, they were decapitated and the nasalmucosa was removed.
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Conclusion & Impact:Thyroid hormone receptor (TR-a, TR-b) status was assessed by immunohistochemical staining.Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormonereceptors in an experimental postnatal hypothyroidism model.Materials and Methods: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospectiverandomized study and were divided into two groups: Group 1 (n=11, methimazole, MMI -induced hypothyroidism group) given MMIwater,and Group 2 (n=10, control group), normal tap water. When the offspring reached 90 days, they were decapitated and the nasalmucosa was removed. Thyroid hormone receptor (TR-a, TR-b) status was assessed by immunohistochemical staining.Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant (p

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Cite This Article

CESUR, G., BAŞAL, Y., GÜNEL, C., ERYILMAZ, A., ELİYATKIN, N. Ö. (2022). The effect of experimental hypothyroidism on nasal mucosa. The Turkish Journal of Ear Nose and Throat, Cilt: 28 - Sayı: 1, 21–25. https://ajindex.com/articles/597955

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References (15)

  1. Gluckman JL, Stegmoyert R. Nonallergic rhinitis. In: Paparella MM, Shumrick DA, Gluckman JL, Meyerhoff WL, editors. Otolaryngology. Vol 3. 3rd ed. Philadelphia: W.B. Saunders; 1991. p. 1889-95
  2. Günel C, Başak HS, Güney E. The relationship between hypothyroidism and rhinitis Tr-ENT 2010;20:163-8
  3. Scadding GK. Non-allergic rhinitis: diagnosis and management. Curr Opin Allergy Clin Immunol 2001;1:15-20
  4. El-Shafie KT. Clinical presentation of hypothyroidism. J Family Community Med 2003;10:55-8
  5. Black RR, Maxon HR. Benign diseases of the thyroid gland. In: Richard Z, editor. Otolaryngology. 3rd ed. Philadelphia: W.B. Saunders; 1991. p. 2483-97
  6. Weisskopf A. Connective tissue: a synthesis of modern thought and its impact on the understanding of nasal disease. Laryngoscope 1960;70:1029-59
  7. Kocaturk T, Ergin K, Cesur G, Evlicoglu GE, Cakmak H. The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level. Cutan Ocul Toxicol 2016;35:36-40
  8. Sack J, Weller A, Rigler O, Rozin A. A simple model for studying the correction of in utero hypothyroidism in the rat. Pediatr Res 1995;37(4 Pt 1):497-501
  9. Ritter FN. The effects of hypothyroidism upon the ear, nose and throat. A clinical and experimental study. Laryngoscope 1967;77:1427-79
  10. Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, et al. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immunol 1998;81(5 Pt 2):478-518
  11. Salib RJ, Harries PG, Nair SB, Howarth PH. Mechanisms and mediators of nasal symptoms in non-allergic rhinitis. Clin Exp Allergy 2008;38:393-404
  12. Proud GO, Lange RD. The effect of thyroidectomy on the nasal mucosa of experimental animals. Trans Am Laryngol Rhinol Otol Soc 1957;59:46-55
  13. Yen PM. Genomic and nongenomic actions of thyroid hormones. In: Braverman LE, Utiger RD, editors. The thyroid: Fundamental and clinical text. Philadelphia: Lippincott Williams and Wilkins; 2005. p. 135
  14. Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, et al. Autonomous functions of murine thyroid hormone receptor TRa a nd T Rb in cochlear hair cells. Mol Cell Endocrinol 2014;382:26-37
  15. Altman KW, Haines GK 3rd, Vakkalanka SK, Keni SP, Kopp PA, Radosevich JA. Identification of thyroid hormone receptors in the human larynx. Laryngosc