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Journals / The Turkish Journal of Ear Nose and Throat / 2018 / Cilt: 28 - Sayı: 1

Expression of roundabout receptor family members 1 and 2 in laryngeal squamous cell carcinoma and correlation with clinical and pathological parameters

Ayşe EREN PÜTÜN
Ender COŞKUNPINAR
Kadir Serkan ORHAN
Deniz KANLIADA
Önder ŞAHİN
Mustafa Ömür KÖSE
Turgay İŞBİR
İlhan YAYLIM
Pages
26–33
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our study results showed that there was no correlation between ROBO-1, ROBO-2 and TGM-3 gene expression and development of laryngeal cancer.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: This study aims to investigate whether there is a role of ROBO-1, ROBO-2 and TGM-3 gene expression levels in the development of laryngeal cancer.
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Key Findings & Data:Patients and Methods: The study was completed with 29 patients who underwent total or partial laryngectomy due to squamouscell laryngeal cancer.
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Conclusion & Impact:Conclusion: Our study results showed that there was no correlation between ROBO-1, ROBO-2 and TGM-3 gene expression and development of laryngeal cancer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Gene expression · laryngeal carcinoma · Roundabout 1

Abstract

Objectives: This study aims to investigate whether there is a role of ROBO-1, ROBO-2 and TGM-3 gene expression levels in the development of laryngeal cancer. Patients and Methods: The study was completed with 29 patients who underwent total or partial laryngectomy due to squamouscell laryngeal cancer. Gene expression analysis was performed by quantitative real-time polymerase chain reaction qRT-PCR . Expression ratios were transformed into fold changes and reported as relative expression. Obtained fold changes were compared between different tumor grades in addition to normal tissue samples. Results: The ROBO-1, ROBO-2 and TGM-3 genes were expressed at a lower level than the control group. Conclusion: Our study results showed that there was no correlation between ROBO-1, ROBO-2 and TGM-3 gene expression and development of laryngeal cancer.

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Cite This Article

PÜTÜN, A. E., COŞKUNPINAR, E., ORHAN, K. S., KANLIADA, D., ŞAHİN, Ö., KÖSE, M. Ö., İŞBİR, T., YAYLIM, İ. (2018). Expression of roundabout receptor family members 1 and 2 in laryngeal squamous cell carcinoma and correlation with clinical and pathological parameters. The Turkish Journal of Ear Nose and Throat, Cilt: 28 - Sayı: 1, 26–33. https://ajindex.com/articles/362563

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