AI Summary & Key Takeaways
AI InsightAs a result, it was detemined that cerebral venous sinus thorombosis observed during pregnancy and postpartum state was of a much better prognosis in cases but pre-existing genetic hipercoagulopathy in pregnancies aggravated the prognosis, therefore it has been suggested that the predetermination of genetic disorders causing hypercoagulopathy in women with pregnancy may interfere with the development of cerebral venous thorombosis which may occur later.
📌 3 Key Takeaways
Abstract
We reviewed 51 patients (32 female, 19 male) with cerebral venous thorombosis were included in our study between 1997 and 2004 years. Diagnosis was confirmed by magnetic resonance (MR) and MR angiography of brain vessels. Headache was observed in 88 % of cases, papilledema 59 %, focal neurological deficitis 71 %, confusion 31%, coma 18 %, seizures 22 % respectively. Postpartum state or pregnancy were determined to be the most comman etiological causes. We observed that venous thrombosis was of superior sagittal sinus involvement in 94 % of cases. Unfractionated heparin was administered to 70 % cases, fractionated heparin was administered to 30 % cases during acute phase treatment. There was good prognosis in 53 %, minimal neurologic deficits in 35 % and mortality in 2 % of them during follow up. As a result, it was detemined that cerebral venous sinus thorombosis observed during pregnancy and postpartum state was of a much better prognosis in cases but pre-existing genetic hipercoagulopathy in pregnancies aggravated the prognosis, therefore it has been suggested that the predetermination of genetic disorders causing hypercoagulopathy in women with pregnancy may interfere with the development of cerebral venous thorombosis which may occur later.
Özet
Çalışmaya 1997-2004 yıllan arasında serebral venöz tromboz tanısı ile takip edilen 32 kadın, 19 erkek toplam 51 hasta alındı. Magnetik rezonans (MR) ve MR angiografi tetkikleri ile tanı konuldu. Olguların %88'inde başağrısı, %59'unda papil ödemi, %71'inde fokal nörolojik defisit, %31'inde konfüzyon, %18'inde koma ve %22'sinde nöbet geçirme gözlendi. Etyolojik neden olarak en sık postpartum periyod veya gebelik saptandı. Olguların %94'ünde, venöz trombozun superior sagittal sinüs yerleşimli olduğu gözlendi. Akut dönem tedavide olguların %70'ine konvansiyonel heparin, %30'una düşük molekül ağırlıklı heparin uygulandı. Takiplerde %53'ünde iyi prognoz, %35'inde minimal nörolojik defisit, '/î 2'sinde ise ölüm görüldü. Sonuç olarak gebelik, postpartum dönemde görülen serebral venöz trombozlu olgularda prognozun daha iyi olduğu gözlendi, fakat gebelerde daha önceden var olan genetik hiperkoagülopatinin prognozu kötüleştirdiği, bu nedenle doğurganlık dönemindeki kadınlarda hiperkoagülopatiye neden olan genetik hastalıkların önceden saptanmasının daha sonra ortaya çıkabilecek serebral venöz tromboz gelişimini engelleyeceği düşünülmektedir.