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Journals / BEYOGLU EYE JOURNAL / 2021 / Cilt: 6 - Sayı: 1

The Inhibitory Effect of Capparis Ovata Polysaccharides on Cultured Pterygium Fibroblasts

ERKUT KÜÇÜK
Kürşat ZOR
IŞIL AYDEMİR
Oktay ÖZKAN
Pages
1–6
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results of this study suggested that Capparis ovata polysaccharides may be a valuable candidate drug to treat pterygium.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Pterygium recurrence after removal surgery is an important problem.
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Key Findings & Data:This study was aninvestigation of the effect of Capparis ovata polysaccharides on cultured pterygium fibroblasts and a comparison with the effects of mitomycin C (MMC).Methods: Pterygium tissue samples were obtained during excision surgery from 3 patients with primary pterygium, and fibroblasts were isolated.
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Conclusion & Impact:The results of this study suggested that Capparis ovata polysaccharides may be a valuable candidate drug to treat pterygium.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: Pterygium recurrence after removal surgery is an important problem. Polysaccharides obtained from Capparis species have been shown to possess various biological properties, including anti-tumor activity. This study was aninvestigation of the effect of Capparis ovata polysaccharides on cultured pterygium fibroblasts and a comparison with the effects of mitomycin C (MMC).Methods: Pterygium tissue samples were obtained during excision surgery from 3 patients with primary pterygium, and fibroblasts were isolated. Pterygium fibroblast cultures and L929 cell cultures were treated with different concentrations of MMC and Capparis ovata polysaccharides. Cell proliferation and migration were evaluated.Results: An MTT assay revealed that cell viability decreased with increasing concentrations of Capparis ovata polysaccharides in both cell types. MMC also inhibited the proliferation of both cell types. A scratch-wound assay indicated thatboth Capparis ovata polysaccharides and MMC molecules reduced proliferation and migration in the pterygium fibroblasts and L929 cells.Conclusion: The in vitro Capparis ovata polysaccharide inhibition of proliferation and migration of pterygium fibroblasts was similar to that of MMC. The results of this study suggested that Capparis ovata polysaccharides may be a valuable candidate drug to treat pterygium.

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Cite This Article

KÜÇÜK, E., ZOR, K., AYDEMİR, I., ÖZKAN, O. (2021). The Inhibitory Effect of Capparis Ovata Polysaccharides on Cultured Pterygium Fibroblasts. BEYOGLU EYE JOURNAL, Cilt: 6 - Sayı: 1, 1–6. https://ajindex.com/articles/353070

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