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Journals / Diagnostic and Interventional Radiology / 2017 / Cilt: 23 - Sayı: 6

Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy

CANAN ALTAY
MUSTAFA SEÇİL
TEVFİK DEMİR
TAHİR ATİK
Gülçin AKINCI
Nilüfer Özdemir KUTBAY
Ela Keskin TEMELOĞLU
Ilgın Yıldırım ŞİMŞİR
Seçil ÖZIŞIK
LEYLA DEMİR
ERDAL EREN
EMİNE BURÇİN TUNA
HASİBE AYTAÇ
HÜSEYİN ONAY
BARIŞ AKINCI
Pages
428–434
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy

📌 3 Key Takeaways

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Objective & Hypothesis:PURPOSE We aimed to investigate residual adipose tissue with whole-body magnetic resonance imaging to differentiate between subtypes of lipodystrophy.
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Key Findings & Data:METHODS A total of 32 patients (12 with congenital generalized lipodystrophy [CGL], 1 with acquired generalized lipodystrophy [AGL], 12 with familial partial lipodystrophy [FPLD], and 7 with acquired partial lipodystrophy [APL]) were included.
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Conclusion & Impact:Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

PURPOSE We aimed to investigate residual adipose tissue with whole-body magnetic resonance imaging to differentiate between subtypes of lipodystrophy. METHODS A total of 32 patients (12 with congenital generalized lipodystrophy [CGL], 1 with acquired generalized lipodystrophy [AGL], 12 with familial partial lipodystrophy [FPLD], and 7 with acquired partial lipodystrophy [APL]) were included. RESULTS Despite generalized loss of metabolically active adipose tissue, patients with CGL1 caused by AGPAT2 mutations had a significant amount of residual adipose tissue in the scalp, earlobes, retro-orbital region, and palms and soles. No residual adipose tissue was noted particularly in the head and neck, palms and soles in CGL2 caused by BSCL2 mutations. CGL4 caused by mutations in the PTRF gene was characterized with well-preserved retro-orbital and bone marrow fat in the absence of any visible residual adipose tissue in other areas. No residual adipose tissue was observed in AGL. Despite loss of subcutaneous fat, periarticular adipose tissue was preserved in the lower limbs of patients with FPLD. Retro-orbital adipose tissue was surprisingly preserved in APL, although they lacked head and neck fat. CONCLUSION Lipodystrophies are a heterogeneous group of disorders characterized by generalized or partial loss of adipose tissue, which can be congenital or acquired. Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy

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Cite This Article

ALTAY, C., SEÇİL, M., DEMİR, T., ATİK, T., AKINCI, G., KUTBAY, N. Ö., TEMELOĞLU, E. K., ŞİMŞİR, I. Y., ÖZIŞIK, S., DEMİR, L., EREN, E., TUNA, E. B., AYTAÇ, H., ONAY, H., AKINCI, B. (2017). Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy. Diagnostic and Interventional Radiology, Cilt: 23 - Sayı: 6, 428–434. https://ajindex.com/articles/350022

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