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Journals / Dicle Tıp Dergisi / 2012 / Cilt: 39 - Sayı: 1

Liken planuslu hastalarda interlökin-2 ve tümör nekrozis faktör-α seviyelerinin değerlendirilmesi

Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus

DERYA UÇMAK
Gökçen BALCI
Mehmet HARMAN
Pages
6–8
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The high levels of IL-2 and TNF-α in lichen planus patients support the role of immunity in the pathogenesis of the disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Lichen planus is an immunologic disease mediated by lymphocytes in which T lymphocytes target at basal cells.
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Key Findings & Data:It is believed that TNF-α that is released from T lymphocytes and keratinocytes plays a key role in the starting and progression of lichen planus by inducing apoptosis.
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Conclusion & Impact:Conclusion: The high levels of IL-2 and TNF-α in lichen planus patients support the role of immunity in the pathogenesis of the disease.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Lichen planus is an immunologic disease mediated by lymphocytes in which T lymphocytes target at basal cells. It is believed that TNF-&#945; that is released from T lymphocytes and keratinocytes plays a key role in the starting and progression of lichen planus by inducing apoptosis. MHC Class-I antigens on basal keratinocytes and interleukin-2 (IL-2) and IFN-gamma (&#947;) that are produced from CD4+ T cells stimulate the apoptosis of keratinocytes in lichen planus. The aim of this study was to measured the IL-2 and TNF-&#945; levels in peripheral blood from patients with Lichen planus. Materials and methods: A total of 26 lichen planus patients (18 females, 8 males) that applied to the dermatology policlinics in Dicle University Hosspital between 2004 and 2006 and a healthy control group were included in the study. Serum IL-2 and TNF-&#945; levels were measured by using Immulate 1000 solid phase and two-site chemiluminescent immunometric assay method. The results of patients and control group were compared. Results: Level of IL-2 (1172.615 ± 774.967) and TNF-&#945; (13.361 ± 5.638) were higher in lichen planus to compared controls. IL-2 and TNF-&#945; levels in the patient group were found to be significantly high statistically compared to health control group, respectively p=0.004 and p<0.001. Conclusion: The high levels of IL-2 and TNF-&#945; in lichen planus patients support the role of immunity in the pathogenesis of the disease.

Özet

Amaç: Liken planus T lenfositlerin bazal hücreleri hedef aldığı lenfosit aracılı immünolojik bir hastalıktır. T lenfositlerinden ve keratinositlerden salınan TNF-αnın apoptozisi indükleyerek liken planusun başlangıç ve progresyonunda anahtar rolü oynadığı düşünülmektedir. Bazal keratinositlerin üzerindeki MHC Class-I antijenler ve CD4+ T hücrelerinden üretilen IL-2 ve IFN-gamma (γ) liken planusta keratinositlerin apoptozisini tetiklemektedir. Bizim çalışmamızın amacı liken planuslu hastaların periferik kanlarındaki İL-2 ve TNF-α seviyelerini saptamaktır. Gereç ve yöntem: Dicle Üniversitesi Tıp Fakültesi Dermatoloji polikliniğine 2004-2006 yılları arasında başvuran 26 liken planuslu hasta (18 kadın, 8 erkek) ve sağlıklı kontrol grubu çalışmaya alındı. Serum IL-2 ve TNF-α seviyeleri Immulate 1000 solid faz ve two-site chemiluminescent immunometric assay yöntemi kullanılarak ölçüldü. Hasta ve kontrol grubunun sonuçları istatistiksel olarak karşılaştırıldı. Bulgular: IL-2 (1172,615 ± 774,967) ve TNF-α (13.361 ± 5,638) seviyeleri liken planuslu hastalarda kontrollere göre daha yüksek saptandı. Hasta grubunda IL-2 ve TNF-α seviyeleri, sağlıklı kontrollere göre istatistiksel olarak anlamlı derecede yüksek bulundu (sırasıyla p=0.004 ve p<0.001). Sonuç: Liken planuslu hastalarda yüksek olarak bulunan IL-2 ve TNF-α seviyeleri hastalığın patogenezinde immünitenin rolünü desteklemektedir.

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Cite This Article

UÇMAK, D., BALCI, G., HARMAN, M. (2012). Liken planuslu hastalarda interlökin-2 ve tümör nekrozis faktör-α seviyelerinin değerlendirilmesi. Dicle Tıp Dergisi, Cilt: 39 - Sayı: 1, 6–8. https://ajindex.com/articles/349746

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References (15)

  1. Carozzo M, Uboldi de Capei M, Dametto et al. Tumor necrosis factor-alpha and interferon-gamma polymorphism contribute to susceptibility to oral lichen planus. J Invest Dermatol 2004; 122(1):87-94
  2. Khan A, Farah CS, Savage NW et al. Oral biology and pathology. J Oral Pathol Med 2003; 32(2):77-83
  3. Sklavounou A, Chrysomali E, Scorilas A, Karameris A. TNF-alpha and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation. J Oral Pathol Med 2000; 29(8): 370-5
  4. Bascones C, Gonzalez MA, Esparza G, Gil JA, Bascones A. Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers. Clin Exp Dermatol 2007;32(5):556-63
  5. Kim SG, Chae CH, Cho BO, Kim HN, Kim HJ, Kim IS, Choi JY. Apoptosis of oral epithelial cells in oral lichen planus caused by upregulation of BMP-4. J Oral Pathol Med 2006 J; 35(1):37-45
  6. Sugerman PB, Satterwhite K, Bigby M. Autocytotoxic T-cell clones in lichen planus. Br J Dermatol 2000; 142(3): 449- 56
  7. Kilpi AM. Activation marker analiysis of mononuclear cell infiltrates of oral lichen planus in situ. Scand J Dent Res 1987; 95(2): 174-80
  8. Jubgell P. Immunoelectron microscopic study of the basement membrane in oral lichen planus. J Cutan Pathol 1990; 17(2): 72-6
  9. Sugerman PB, Savage NW. Oral lichen planus: causes, diagnosis and management. Aust Dent J. 2002; 47(4): 290-7
  10. Cohen JJ. Apopitosis. Immunol Today 1993; 14(3): 126-30
  11. Neppelberg E, Johannessen AC, Jonsson R. Apoptosis in oral lichen planus. Eur J Oral Sci. 2001; 109(5): 361-4
  12. Simark MC, Jobtell M, Bergenholtz G et al. Distribution of interferon-γ mRNA-positive cells in oral lichen planus lesions. J Oral Pathol Med 1999; 27(10): 483-8
  13. Ishii T. Immunohistochemical demonstration of T cell subsets and accessory ceels in oral lichen planus. J Oral Pathol 1987; 16(7): 356-61
  14. Rich AM, Reade PC. A quavtitative assesment of langerhans ceels in oral mucosal lichen planus and leukoplakia. Br J Dermatol 1989; 120(2): 223-8
  15. Constant SL, Bottomly K. Induction of Th 1 and Th 2 CD+ T cell responses: the alternative approaches. Annu Rev Immunol 1997; 15: 297-322.