Journals / Dicle Tıp Dergisi / 2011 / Cilt: 38 - Sayı: 2

A rare cause of diarrhea: eosinophilic gastroenteritis

İshalin nadir bir nedeni: eozinofilik gastroenterit

Pages
244–246
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, the antihistamines are also used solely or combined with glucocorticoids.

📌 3 Key Takeaways

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Objective & Hypothesis:Eosinophilic gastroenteritis (EG) is a rare disease that is characterized by an eosinophil-driven inflammation of the digestive tract, presenting with gastrointestinal symptoms.
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Key Findings & Data:A 68-year-old man admitted to hospital due to diarrhea, nausea, abdominal pain, and weight loss started two weeks ago.
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Conclusion & Impact:However, the antihistamines are also used solely or combined with glucocorticoids.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Eosinophilic gastroenteritis (EG) is a rare disease that is characterized by an eosinophil-driven inflammation of the digestive tract, presenting with gastrointestinal symptoms. In this report, a case of EG in an elderly man who presented with diarrhea was presented. A 68-year-old man admitted to hospital due to diarrhea, nausea, abdominal pain, and weight loss started two weeks ago. Hypereosinophilia were determined. Serum immunoglobulin E level was high. Stool examinations for intestinal parasites were negative. Biopsies were taken from esophagus, stomach, duodenum during upper and lower gastrointestinal endoscopies. Histopathological assessement showed an intense edema, eosinophilic and increased lymphoplasmasitic infiltration in lamina propria. Increased eosinophil count seen in bone-marrow biopsy, atypical cell was not seen. Eosinophilic gastroenteritis was considered and, ketotifen 2 mg/day and methylprednisolone 1 mg/kg/day were started. His symptoms were improved. Gastrointestinal symptoms of EG are nonspecific. The increase of eosinophilic cells in the circulating blood can suggest the possibility of EG. Definite diagnosis is made by histopathological assessment. Glucucorticoid therapy is the mainstay and is effective in the treatment of EG. However, the antihistamines are also used solely or combined with glucocorticoids.

Özet

Eozinofilik gastroenterit (EGE), gastrointestinal semptomlara yol açan sindirim kanalının eozinofilik infiltrasyonu ile karakterize nadir bir hastalıktır. Bu yazıda ishal nedeni araştırılırken teşhis edilen yaşlı bir EGE vakasını sunulmuştur. Altmış sekiz yaşında erkek hasta; yaklaşık 2 hafta önce başlayan iştahsızlık, ishal, karın ağrısı, kilo kaybı nedeniyle hastanemize başvurdu. Hastanın tam kan sayımında bariz eozinofili mevcuttu. Serum immünglobulin E düzeyi yüksekti. Gaita incelemelerinde parazit görülmedi. Özofagus, mide, duodenum ve rektumdan alınan biyopsilerin histopatolojik incelemesinde lamina propriada yoğun ödem ve eozinofil infiltrasyonun eşlik ettiği lenfoplazmositer hücre infiltrasyonu mevcuttu. Eozinofil artışı ile seyreden hipersellüler kemik iliği saptandı, atipik hücre yoktu. Hastada eozinofilik gastroenterit düşünüldü. Ketotifen 2 mg/gün ve metilprednizolon 1 mg/kg/gün başlandı. Semptomları düzeldi. Eozinofilik gastroenteritte semptomlar hastalığa özgü değildir. Periferik eozinofili hastalığı düşündürür. Kesin teşhis histopatolojik incelemeyle konur. Tedavisinde glukokortikoid tedavi ana unsurdur ve etkilidir. Antihistaminikler de yalnız veya glukokortikoidlerle birlikte kullanılmaktadır.

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Cite This Article

YENİOVA, A. Ö., NAZLIGÜL, Y., ÇAĞLAR, F., KEFELİ, A., KÜÇÜKAZMAN, M., ŞİMŞEK, G. (2011). A rare cause of diarrhea: eosinophilic gastroenteritis. Dicle Tıp Dergisi, Cilt: 38 - Sayı: 2, 244–246. https://ajindex.com/articles/349621

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References (10)

  1. Whitaker IS, Gulati A, McDaid JO, Bugajska-Carr U, Arends MJ. Eosinophilic gastroenteritis presenting as obstructive jaundice. Eur J Gastroenterol Hepatol 2004;16 (5):407-9
  2. Dursun M, Yılmaz Ş, Canoruç F, Sarı Y. Eozinofilik gastroenterit: assit ile başvuran bir vaka. Turkiye Klinikleri Gastroenterohepatoloji Dergisi 2003;14(2):195-7
  3. Verheijden NA, Ennecker-Jans SA. A rare cause of abdominal pain: Eosinophilic gastroenteritis. Neth J Med 2010;68(4):367-9
  4. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004;113 (1):11-28
  5. Fleischer DM, Atkins D. Evaluation of the patient with suspected eosinophilic gastrointestinal disease. Immunol Allergy Clin North Am 2009;29(1):53-63
  6. Straumann A, Simon HU. The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract. Allergy 2004;59 (1):15–25
  7. Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 1990;31(1):54–8
  8. Khan S. Eosinophilic gastroenteritis. Gastroenterol Clin North Am 2008;37(1):333-48
  9. Bolukbas FF, Bolukbas C, Uzunkoy A, Baba F, Horoz M, Öztürk G. A dramatic response to ketotifen in case of eosinophilic gastroenteritis mimicking abdominal emergency. Dig Dis Sci 2004;49(12):1782-5
  10. Erdem L, Akbayır N. Eozinofilik gastroenterit. Güncel Gastroenteroloji Dergisi 2004;8(3):252-60.