Journals / Dicle Tıp Dergisi / 2021 / Cilt: 48 - Sayı: 2

The Comparison of Bone Mineral Densitometry Values and Hematological Parameters in Postmenopausal Women

Postmenopozal Kadınlarda Kemik Mineral Dansitometri Değerleri ile Hematolojik Parametrelerin Karşılaştırılması

Pages
267–273
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: High platelet lymphocyte ratio and low monocyte value can be simple markers that can be used to help predict changes in bone density ratio after menopause.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We aimed to evaluate the relationship between hemogram values, neutrophil lymphocyte ratio, platelet lymphocyte ratio and bone mineral densitometry values in postmenopausal women and thus to determine which parameter is in a stronger relationship with bone mineral densitometry values.
📊
Key Findings & Data:Method: In this study, bone mineral densitometry values, neutrophil lymphocyte ratio, platelet lymphocyte ratio and hematological parameters (white blood cell, red blood cell, hemoglobin, platelet, lymphocyte, monocyte, basophil, neutrophil, eosinophil) of 64 postmenopausal female patients aged 50-60, with a body mass index in the range of 25-30 were retrospectively reviewed.
💡
Conclusion & Impact:Conclusion: High platelet lymphocyte ratio and low monocyte value can be simple markers that can be used to help predict changes in bone density ratio after menopause.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to evaluate the relationship between hemogram values, neutrophil lymphocyte ratio, platelet lymphocyte ratio and bone mineral densitometry values in postmenopausal women and thus to determine which parameter is in a stronger relationship with bone mineral densitometry values. Method: In this study, bone mineral densitometry values, neutrophil lymphocyte ratio, platelet lymphocyte ratio and hematological parameters (white blood cell, red blood cell, hemoglobin, platelet, lymphocyte, monocyte, basophil, neutrophil, eosinophil) of 64 postmenopausal female patients aged 50-60, with a body mass index in the range of 25-30 were retrospectively reviewed. Clinical conditions that may affect bone mineral density or hemogram values (acute and chronic infections, oncological, rheumatological and hematological diseases, chronic liver and kidney diseases, hyperparathyroidism, hypothyroidism, hyperthyroidism, vitamin D deficiency, steroid use, and a history of trauma or blood transfusion in the last one year) were excluded from the study. Then, correlation analysis was performed between bone mineral densitometry values and hematological parameters. Results: In our study, a statistically significant negative correlation was found between platelet lymphocyte ratio and femoral neck bone mineral density, femoral neck Z-score and femoral neck T-score (p=0.004, r=-0.353; p=0.005, r=-0.344; p=0.004, r=-0.359, respectively). In addition, a statistically significant positive correlation was found between monocyte values and femoral neck bone mineral density, femoral neck Z-score and femoral neck T-score. (p=0.030, r=0.272; p=0.038, r=0.259; p=0.022, r=0.285, respectively). There was no relationship between neutrophil lymphocyte ratio and bone mineral densitometry parameters. Conclusion: High platelet lymphocyte ratio and low monocyte value can be simple markers that can be used to help predict changes in bone density ratio after menopause.

Özet

Amaç: Postmenopozal kadınlarda hemogram değerleri, nötrofil lenfosit oranı, trombosit lenfosit oranı ve kemik mineral dansitometri değerleri arasındaki ilişkiyi değerlendirerek hangi parametrenin kemik mineral dansitometri değerleri ile daha güçlü bir ilişki içinde olduğunu belirlemeyi amaçladık. Yöntemler: Bu çalışmada vücut kitle indeksi 25-30 arasında değişen, 50-60 yaş arası 64 postmenopozal kadın hastanın kemik mineral dansitometri değerleri, nötrofil lenfosit oranı, trombosit lenfosit oranı ve hemogram parametreleri (beyaz kan hücresi, kırmızı kan hücresi, hemoglobin, platelet, lenfosit, monosit, basofil, nötrofil, eosinofil) geriye dönük olarak incelendi. Kemik mineral yoğunluğunu veya hemogram değerlerini etkileyebilecek klinik durumlar (akut ve kronik enfeksiyonlar, onkolojik, romatolojik ve hematolojik hastalıklar, kronik karaciğer ve böbrek hastalıkları, hiperparatiroidi, hipotiroidi, hipertiroidi, D vitamini eksikliği, steroid kullanımı ve son 1 yıl içerisinde geçirilmiş travma veya kan transfüzyonu öyküsü) çalışma dışı bırakıldı. Daha sonra kemik mineral dansitometri değerleri ile hematolojik parametreler arasında korelasyon analizi yapıldı. Bulgular: Çalışmamızda platelet lenfosit oranı ile femur boynu kemik mineral dansitesi, femur boynu Z skoru ve femur boynu T skoru arasında istatistiksel olarak anlamlı negatif korelasyon saptandı (p=0.004, r=-0.353; p=0.005, r=-0.344; p=0.004, r=-0.359, respectively). Ayrıca monosit değerleri ile femur boynu kemik mineral dansitesi, femur boynu Z skoru ve femur boynu T skoru arasında istatistiksel olarak anlamlı pozitif korelasyon saptandı (p=0.030, r=0.272; p=0.038, r=0.259; p=0.022, r=0.285, respectively). Nötrofil lenfosit oranı ile kemik mineral dansitometri parametreleri arasında ilişki saptanmadı. Sonuç: Yüksek platelet lenfosit oranı ve düşük monosit değeri, menopoz sonrası kemik dansite oranlarındaki değişimleri tahmin etmeye yardımcı olmak için kullanılabilecek basit belirteçler olabilir.

🔖

Cite This Article

GÜZEL, Y., UYAR, A., TUZCU, Ş. A., KAPLAN, İ., ERGÜL, S., YILDIRIM, M. S., SOYLU, H., TAŞDEMİR, B. (2021). The Comparison of Bone Mineral Densitometry Values and Hematological Parameters in Postmenopausal Women. Dicle Tıp Dergisi, Cilt: 48 - Sayı: 2, 267–273. https://ajindex.com/articles/349429

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Consensus development conference: diagnosis,prophylaxis, and treatment of osteoporosis. Am JMed. 1993
  2. Harvey N, Dennison E, Cooper C. Osteoporosis:impact on health and economics. Nat RevRheumatol. 2010
  3. Yun AJ, Lee PY. Maldaptation of the link betweeninflammation and bone turnover may be a keydeterminant of osteoporosis. Med Hypotheses.2004
  4. Manolagas SC, Jilka RL. Bone marrow, cytokines,and bone remodeling. Emerging insights into thepathophysiology of osteoporosis. N Engl J Med.1995
  5. Lei Z, Xiaoying Z, Xingguo L. Ovariectomy-associated changes in bone mineral density andbone marrow haematopoiesis in rats. Int J ExpPathol. 2009
  6. Kimble RB, Matayoshi AB, Vannice JL, et al.Simultaneous block of interleukin-1 and tumornecrosis factor is required to completely preventbone loss in the early postovariectomy period.Endocrinology. 1995
  7. Nanes MS. Tumor necrosis factor-alpha: molecularand cellular mechanisms in skeletal pathology. Gene.2003
  8. Kutlucan A, Tunc S, Baltacı D, ve ark. Behçethastalarında serum TNF- α veosteoprotegerin düzeyi ve kemik kitle yoğunluğu.Dicle Tıp Dergisi. 2012
  9. Barbour KE, Boudreau R, Danielson ME, et al.Inflammatory markers and the risk of hip fracture:the Women's Health Initiative. J Bone Miner Res.2012
  10. Papa A, Emdin M, Passino C, et al. Predictivevalue of elevated neutrophil-lymphocyte ratio oncardiac mortality in patients with stable coronaryartery disease. Clin Chim Acta. 2008
  11. Can C. Correlation of (18F) FDG PET/CTParameters with Haematological Parameters inEsophageal Cancers and the Effect of TheseParameters on Survival. Dicle Tıp Dergisi, 2020
  12. Torun S, Tunc BD, Suvak B, et al. Assessment ofneutrophil-lymphocyte ratio in ulcerative colitis: apromising marker in predicting disease severity.Clin Res Hepatol Gastroenterol. 2012
  13. Zengin O, Onder ME, Kalem A, et al. Newinflammatory markers in early rheumatoid arthritis.Z Rheumatol. 2018
  14. Sun X, Liu X, Liu J, et al. Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyteratio in predicting survival for patients with stage I-II gastric cancer. Chin J Cancer. 2016
  15. Tanrikulu AC, Abakay A, Komek H, Abakay O.Prognostic value of the lymphocyte-to-monocyteratio and other inflammatory markers in malignantpleural mesothelioma. Environ Health Prev Med.2016
  16. Öztürk ZA, Ye