Journals / Dicle Tıp Dergisi / 2004 / Cilt: 31 - Sayı: 1

Biochemical features of nonalcholic hepatosteatosis

Nonalkolik hepatosteatozun biyokimyasal özellikleri

Pages
23–26
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion patients with hepatosteatosis must be evaluated with respect to steatohepatitis and, if necessary, must be treated.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study we investigated the biochemical features of patients with NASH in Southestern Anatolia.
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Key Findings & Data:One hundered and two patients were included in the study (mean age 42.1; 52 (51%) female, 50 (49%) male).
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Conclusion & Impact:In conclusion patients with hepatosteatosis must be evaluated with respect to steatohepatitis and, if necessary, must be treated.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Türkiye · Yağlı karaciğer · Turkey

Abstract

In this study we investigated the biochemical features of patients with NASH in Southestern Anatolia. One hundered and two patients were included in the study (mean age 42.1; 52 (51%) female, 50 (49%) male). Fifty six patients were overweight, 27 were obese and 2 were morbid obese. Out of 102 patients 34 were in steatohepatitis group. Median AST level was 34.6 U/L and ALT was 51.9 U/L. Tehre was diabetes mellitus in 15 patients. Obesity, hyperlipidemia and diabetes mellituswere important risk factors for NASH in our region. Steatohepatitis was more comman in male group. In conclusion patients with hepatosteatosis must be evaluated with respect to steatohepatitis and, if necessary, must be treated.

Özet

Bu çalışmada Güneydoğu Anadolu Bölgesindesi’ndeki Non-alkolik karaciğer yağlanması olgularının biyokimyasal özelliklerini araştırdık. Çalışmamızda 102 hastanın ortalama yaşı 42.1 bulundu. Hastaların 52’si kadın (%51), 50’si erkek (%49) idi. 56’sında aşırı kilo (%54.9) 27’sinde obezite (%26.4) 2 vakada (%1.9) morbit obezite mevcuttu. Yüz iki hastanın 34’ünde steatohepatit tespit edildi. Hastaların ortalama AST düzeyi 34.6 U/L, ortalama ALT düzeyi 51.9 U/L idi. Diabetes mellituslu toplam 15 hasta mevcuttu. Bölgemiz için obezite, hiperlipidemi ve diabetes mellitus nonalkolik karaciğer yağlanması için önemli risk faktörleridir. Erkeklerde steatohepatit daha sık görülmektedir. Sonuç olarak hepatosteatozlu hastaların steatohepatitis varlığı bakımından takibi ve endikeyse tedavisi gerekmektedir.

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Cite This Article

BAYAN, K., DANIŞ, R., ALTINTAŞ, A., KEKLİKÇİ, S. U. (2004). Biochemical features of nonalcholic hepatosteatosis. Dicle Tıp Dergisi, Cilt: 31 - Sayı: 1, 23–26. https://ajindex.com/articles/349413

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References (15)

  1. Teli MR, James OF, Burt AL, Benneth MK, Day CP. The natural history of nonalcoholic fatty liver: a follow up study. Hepatology 1995;22:1714-1719
  2. Matteoni CA, Yaunossi ZM, Gramlich T, Boparai N, Liu YC and Mccullought A. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999;116:1413-9
  3. Washington K, Wright K, Shys Y, et al. Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver. Human Pathol 2000;31:822-8
  4. Caldwell SH, Oelsner DH, Lezzoni JC, et al. Criptogenic cirrhosis: clinical caracterisation and risk factors for underlying disease. Hepatology 1999;29:664-9
  5. Abdelmelek M, Ludwig J, Linder KD. Two cases from the spectrum of nonalcoholic steatohepatitis. J Clin Gastroenterol 1995;20:127-130
  6. Yngue Falck-ytter MD and Arthur J, Mccullough MD. Clinical features and natural history of Nonalcoholic steatosis syndromes. Sem Liver Disease 2001;21:17-26
  7. Powell E.E, Cooksley W.G.E, Hanseen R, et al. The natural history of nonalcolic steatohepatitis. A fallow up study of forty two patients follwed for up to 21 years. Hepatology 1990; 11:74
  8. Bacon BR, Farahvash MJ, Jannay CG, Nuschwander-Tetry BA. Nonalcoholic steatohepatitis and expanded clinical entity. Gastroenterology 1994;107:1103-9
  9. Itoh S, Yougel T, Kawagoe K. Companser between nonalcoholic steatohepatitis and alcoholic hepatitis. AM J Gastroenterol 1987;82:650-4
  10. Diehl AM, Goodman Z, Ishak KG. Alcoholic diseases in nonalcoholics: a clinical and histologic comparison with alcohol induced liver injury. Gastroenterology 1998;95:1056-62
  11. Lee RG. Nonalcoholic steatohepatitis: a study of 49 patients. Hum Pathol 1989;20:594 12. Ludwig J, Viggiano TR, Mc Gill DB, et al. Nonalcoholic steatohepatitis. Mayo clinic experiences with a hither to unnamed disease. Mayo Clin Proc 1980;55:434-8
  12. Nonomura A, Mizukami Y, Unoura M, et al. Clinicopathologic study of alcohol-like liver disease in nonalcoholics: nonalcoholic steatohepatitis and fibrosis. Gastroenterol JPN 1992;27:521-8
  13. Angulo P, Keach JC, Batts KP, et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999;30:1356-62
  14. Pinto HC, Baptista A, Camilo ME, Valente A, Saragoca A, De Maura MC. Nonalcoholic steatohepatitis. Clinicopatholo-gic comparison with alcoholic steatohepatitis in ambulatory and hospitalized patients. Dig Dis Sci 1996;41:172-9
  15. Bahçecioğlu İH, Şentürk H, Mert A, Başaran