Journals / Dicle Tıp Dergisi / 2006 / Cilt: 33 - Sayı: 4

Ghrelin; The renown hormone

Ghrelin; gündemdeki hormon

Pages
268–272
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is well known that ghrelin participates in the regulation of many functions in the body

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ghrelin , a 28 amino acid gastric peptide, was found to be a potent releaser of GH and in addition, actively participate in controlling energy balance and the regulation of food intake.
📊
Key Findings & Data:Specifically, plasma ghrelin originates in the oxyntic gland where A-like cells exist and is secreted into the bloodstream.
💡
Conclusion & Impact:It is well known that ghrelin participates in the regulation of many functions in the body
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Peptid hormonlar · Nitrik oksit · Büyüme hormonu

Abstract

Ghrelin , a 28 amino acid gastric peptide, was found to be a potent releaser of GH and in addition, actively participate in controlling energy balance and the regulation of food intake. Specifically, plasma ghrelin originates in the oxyntic gland where A-like cells exist and is secreted into the bloodstream. Lower concentrations have also been reported at various regions in the body. It is well known that ghrelin participates in the regulation of many functions in the body

Özet

Ghrelin, büyüme hormonu salgılatıcı etkisi olan, enerji dengesi ve besin alınımının düzenlenmesinde rol oynayan 28 aminoasitli bir hormondur. Başlıca midenin oksintik bezlerinde bulunan özelleşmiş A-benzeri hücreleri tarafından kan akımına salınır ancak daha düşük düzeylerde olmak üzere, vücudun diğer birçok bölgesinden salındığı da gösterilmiştir. Ghrelin hormonunun birçok fonksiyonlara sahip olduğu, yapılan deneysel çalışmalardan anlaşılmış bulunmaktadır.

🔖

Cite This Article

BİLGİN, H. M. (2006). Ghrelin; The renown hormone. Dicle Tıp Dergisi, Cilt: 33 - Sayı: 4, 268–272. https://ajindex.com/articles/349357

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Kojima M, Hosoda H,Date Y: Ghrelin is a growth-hormone-releasing acylatedpeptide from stomach. Nature,1999;402:656- 660
  2. Casanueva FF, Dieguez C: Ghrelin; The link connecting growth with metabolism and energy homeostasis. Reviews in Endocrine Disorders,2002;3:325-338
  3. Hosoda H, Kojima M, Matsuo H, Kangawa K: Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem,2000; 29:1995- 2000. 4.Tanaka M, Hayashida Y, Nakao N, Nakai N, Nakashima K: Testis-spesific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochem Biophys Acta, 2001; 1522: 62- 65. 5.Bowers CY, Momany F,Reynolds GA, Chang D, Hong A, Chang K: Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro.Endocrinol, 1980;106:663-667
  4. Korbonits M, Bustin SA, Kojima M: The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pitiutary and other neuroendocrine tumors. J Clin Endocrinol Metab, 2001; 86: 881- 887
  5. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI et al: A receptor in pituitary and hypothalamus that functions in growth hormone release. Science, 1996; 273: 974- 977
  6. Petersenn S: Structure and regulation of the growth hormone secretagogue receptor. Minerva Endocrinol,2002; 27:243-256
  7. Ghigo E, Avrat E, Broglio F, Giordano R, Gianotti L, Muccioli G et al: Endocrine and non-endocrine activities of growth hormone secretagogues in humans. Horm.Res.,1999; 51:9-15
  8. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T et al: Stomach is a major source of circulating ghrelin and feeding state determines plasma ghrelin-like immuno reactivity levels in humans. Journal of Clinical Endocrinology and Metabolism, 2001; 86: 4753- 4758
  9. Barreiro ML, Gaytn F,Caminos JE: Cellular location and hormonal regulation of ghrelin expression in rat testis. Biol Reprod,2002a; 67: 1768 -1776
  10. Sleisenger C, Foltran B. Gastrointestinal and Liver Disease: WB Saunders7th ed., 2002
  11. Volante M, Allia E, Gugliotta P: Expression of ghrelin and GHS reseptor by pankreatic islet cells and related endocrine tumors.J Clin Endocrinol Metab, 2002a:87:1300-1308
  12. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M: Ghrelin and the regulation of energy balance- a hypothalamic perspective (Review). Endocrinology,