Journals / Dicle Tıp Dergisi / 2008 / Cilt: 35 - Sayı: 1

Radioprotective egents

Radyoprotektif etkili ajanlar

Pages
69–76
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It has been suggested that the radioprotective activity of bee venom components is related with the stimulation of the hematopoetic system.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Since1949, a great deal of research has been carried out on the radioprotective activity of various chemical substances.
📊
Key Findings & Data:Thiol compounds, compounds which contain –SH radical, different classes of pharmacological agents and other compounds such as vitamine C and WR- 2721 have been shown to reduce mortality when administered prior to exposure to a lethal dose of radiation.
💡
Conclusion & Impact:It has been suggested that the radioprotective activity of bee venom components is related with the stimulation of the hematopoetic system.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Since1949, a great deal of research has been carried out on the radioprotective activity of various chemical substances. Thiol compounds, compounds which contain –SH radical, different classes of pharmacological agents and other compounds such as vitamine C and WR- 2721 have been shown to reduce mortality when administered prior to exposure to a lethal dose of radiation. Recently, honey bee venom as well as that of its components melittin and histamine have shown to be valuable in reduction of radiation-induced damage and also provide prophylactic alternative treatment for serious side effects related with radiotherapy. It has been suggested that the radioprotective activity of bee venom components is related with the stimulation of the hematopoetic system.

Özet

1949 yılından bu yana, çalışmalar çeşitli kimyasal bileşiklerin radyasyon hasarına karşı koruyucu etkinliği üzerinde yoğunlaşmıştır. Thiol bileşikleri, -SH grubu içeren bileşikler, farklı farmakolojik ajanlar ve C vitamini ile WR-2721 gibi diğer ajanların ölümcül dozda radyasyona maruziyet öncesinde verilmeleri halinde mortalitede düşüş sağlayabildikleri görülmüştür. Son olarak bal arısı zehirinin ve bileşimindeki melittin ile histaminin radyasyondan kaynaklanan hasarı azaltmada değerli olabildiği gibi radyoterapiyle ilişkili yan etkilere karşı da profilaktik tedavi seçeneği sunduğu gösterilmiştir. Arı zehiri bileşenlerinin radyoprotektif etkilerini hematopoetik sistemi uyarmak suretiyle oluşturdukları düşünülmektedir.

🔖

Cite This Article

KELLE, İ. (2008). Radioprotective egents. Dicle Tıp Dergisi, Cilt: 35 - Sayı: 1, 69–76. https://ajindex.com/articles/349302

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Varanda EA, Tavares DC. Radioprotection: mechanisms and radioprotective agents including honeybee venom. J. Venom. Anim. Toxins, 1998; 4:5-21
  2. Prasad KN. Rationale for using multiple antioxidants in protecting humans against low doses of ionizing radiation. Br J Radiol. 2005; 78: 485-492
  3. Muscatello AC. Nutritional supplements as radioprotectors: a review and proposal. http://www.marssociety.org/content/proceedin gs1998/mar98074.htm 4. Biaglow JE, Varnes ME, Clark EP, Epp ER. The role of thiols in cellular response to radiation and drugs. Radiat Res. 1983; 95: 437- 455
  4. Bonsack ME, Felemovicius I, Baptista ML, Delaney JP. Radioprotection of the intestinal mucosa of rats by probucol. Radiat Res. 1999; 151: 69-73
  5. Fedorocko P, Mackova NO. Radioprotective effects of combination Broncho-Vaxom, a macrophage activator, and indomethacin, an inhibitor of prostaglandin production: a relationship to myelopoiesis. Eur J Haematol. 1996; 56:54-61
  6. Fedorocko P, Mackova NO. Combined modality radioprotection: enhancement of survival and hematopoetic recovery in gamma- irradiated mice by the joint use of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) and indomethacin. Int J Immunopharmacol. 1996; 18: 329-337
  7. Floersheim GL. Radioprotective effects of calcium antagonists used alone or with other types of radioprotectors. Radiat Res. 1993; 135: 438-439
  8. Klimberg VS, Souba WW, Dolson DJ, et al. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer. 1990; 66:62-68
  9. Klimberg VS, Salloum RM, Kasper M, et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg. 1990; 125:1040-1045. 11. 5.el-Nahas SM, Mattar FE, Mohamed AA. Radioprotective effects of vitamins C and E. Mutat Res. 1993; 301:143-147
  10. Felemovicius I, Bonsack ME, Baptista ML, Delaney JP. Intestinal radioprotection by vitamin E(alpha-tocopherol). Ann Surg. 1995; 222:504-508
  11. Prasad KN. Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Integr Cancer Ther. 2004; 3:310- 322
  12. Prasad KN. Rationale for using high- dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr. 2004; 134: 3182-3183
  13. Mackova NO, Fedorocko P. Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoesis and circulating blood cells. Neoplasma. 1995; 42:25-30
  14. Fedoroc