AI Summary & Key Takeaways
AI InsightConclusion: PCT can be a useful indicator for morbidity and prognosis in COPD patients.
📌 3 Key Takeaways
Abstract
Objectives: The aim of this study was to investigate the correlation between procalcitonin and other acute phase reactants, and also analyze their relationship with clinical situation in chronic obstructive pulmonary disease (COPD) acute exacerbations. Materials and methods: The study was made with 122 acute COPD exacerbated patients, who were admitted to emergency service. Patients with below 0.25 ng/ml PCT value included Group 1, and the patients with PCT values ≥ 0.25 ng/ml Group 2. Serum procalcitonin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values and white blood cell (WBC) counts were measured. Also, patients hospitalization time and mortality rates were recorded and compared with PCT. Results: Patients were divided in 3 groups according to their clinical diagnosis; Pneumonia (n=27), Mycoplasma-Chlamydia pneumonia (n=11) and the patients with only COPD exacerbation(n=84). Mean PCT values according to the groups were 9.47 ± 8.1 ng/ml, 0.41 ± 0.2 ng/ml, and 0.21 ± 0.05 ng/ml respectively. The relationship between PCT with CRP and white blood cell has been found between significiant (p=0.001, p=0.005 respectively), whereas the relationship between PCT and ESR was nonsignificant (p=0.55). Procalcitonin and CRP had a positive correlation with the hospitalization time (p=0.034, p=0.022 respectively). The mean ± standard error of PCT for the patients who died was 28.3 ± 27.5 ng/ml, and the difference between patients who died or were discharged was statistically significant (p= 0.012). Conclusion: PCT can be a useful indicator for morbidity and prognosis in COPD patients.
Özet
Amaç: Çalışmanın amacı kronik obstruktif akciğer hastalığı (KOAH) akut alevlenmeli hastaların serum prokalsitonin (PCT) ölçümü ile diğer akut faz belirteçlerini karşılaştırmak ve klinikle ilişkisini araştırmaktır. Gereç ve yöntem: Çalışma acil servise başvuran 122 KOAH akut alevlenmeli hasta ile yapıldı. Prokalsitonin (PCT) değeri 0.05). Hastaların PCT ve CRP değerleri ile hastanede kalış süreleri arasında aynı yönlü ilişki saptandı (sırasıyla p=0.034, p=0.022). Eksitus olan hastalardaki PCT ortalama değeri 28.3 ± 27.5 ng/ml olup taburcu olanlara oranla anlamlı olarak yüksek bulundu (p= 0.012). Sonuç: Elde ettiğimiz verilere dayanarak PCT’nin KOAH akut alevlenmeli hastalarda morbidite ve prognozunun belirlenmesinde yararlı bir gösterge olarak kullanılabileceği sonucuna varıldı.