Journals / Dicle Tıp Dergisi / 2015 / Cilt: 42 - Sayı: 3

Evaluation of 14 patients performed radiotherapy due to Kaposi sarcoma

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

Pages
326–330
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Side effects such as edema and pain may be relieved by supportive treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In our study, we evaluated the clinical character- istics and outcomes of treatment in patients with Kaposi’s sarcoma (KS).
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Key Findings & Data:Methods: The patients undergoing radiotherapy (RT) be- cause of the KS between the years 2005-2012 in Radiation Oncology Department of Dicle University Hospital were in- cluded.
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Conclusion & Impact:Side effects such as edema and pain may be relieved by supportive treatment.
🔬Design:Research Article
📍Scope:2005-2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In our study, we evaluated the clinical character- istics and outcomes of treatment in patients with Kaposi’s sarcoma (KS). Methods: The patients undergoing radiotherapy (RT) be- cause of the KS between the years 2005-2012 in Radiation Oncology Department of Dicle University Hospital were in- cluded. All patients underwent RT with different dose-frac- tionation schemes to increase quality of life and to palliate the symptoms. Patients with lesions in multiple regions un- derwent RT in the same or different dates. Responses to radiotherapy were recorded as complete or partial response. Results: Fourteen patients received radiotherapy because of f KS were evaluated retrospectively. Twenty two differ- ent regions of 14 patients underwent RT . Only one patient (4.5%) was performed RT to glans penis as a third region while performed to the two regions in six patients (27.3%). At irradiations, 6 MV and 10 MV photon energies with 6 MeV, 9 MeV and 12 MeV electron energy were used. Water phan- tom or bolus material was used to obtain a homogeneous dose distribution in the photon irradiation. RT dose adminis- tered to a total of 22 different regional was median 800 cGy (Range: 800-3000 cGy). Median number of RT fractions was 1 (Range: 1-10). When treatment response were evaluated stable disease was present in the 4 (18.1%) regions. Partial response was achieved in eight (36.4%) regions, complete response in 10 (45.5%). RT-related common lymphedema in the feet and legs was observed in the four (57.3%) regions in the acute period. Complication of pain was present in two (28.7%) re- gions. Conclusion: RT is an appropriate and effective treatment regimen in the palliative treatment of KS lesions. Excellent response rates of skin lesions may be obtained by RT. Le- sions and symptoms such as itching may be lost after RT. Side effects such as edema and pain may be relieved by supportive treatment.

Özet

Amaç: Çalışmamızda Kaposi sarkomu (KS) tanısı nede- niyle radyoterapi (RT) uygulanan hastaların klinik özellik- lerini ve tedavi sonuçlarını değerlendirdik. Yöntemler: Çalışmaya Dicle Üniversitesi Hastanesi Rad- yasyon Onkolojisi Kliniğinde 2005-2012 yılları arasında RT uygulanan KS tanılı hastalar dahil edildi. Tüm hastala- ra semptomların palyasyonu ve yaşam kalitesini arttırmak için farklı doz-fraksiyonasyon şemaları ile RT uygulandı. Birden çok bölgesinde lezyonu olan hastalara aynı veya farklı tarihlerde RT uygulandı. Hastaların radyoterapiye cevapları tam veya kısmi yanıt olarak kaydedildi. Bulgular: KS nedeniyle radyoterapi uygulanan 14 hasta retrospektif olarak değerlendirildi. On dört hastanın toplam 22 farklı bölgesine RT uygulandı. Altı hastada (%27,3) iki ayrı bölge ışınlanırken, yalnız bir hastada (%4,5) üçüncü bölge olarak glans penisteki lezyona RT uygulandı. Işınla- malarda 6 MV ve 10 MV foton enerjileri ile 6 MeV, 9 MeV ve 12 MeV elektron enerjileri kullanıldı. Foton ışınlamala- rında homojen doz dağılımı elde etmek için su fantomu veya bolus materyali kullanıldı. Uygulanan RT dozu top- lam 22 farklı bölge için medyan 800 cGy (800-3000 cGy) idi. RT fraksiyon sayısı medyan 1di (1-10). Tedavi yanıt- ları değerlendirildiğinde 4 (%18,1) bölgede stabil hastalık mevcuttu. Sekiz (%36,4) tedavi bölgesinde kısmi cevap sağlanırken, 10 (%45,5) bölgede de tam cevap elde edil- di. Dört (%57,3) tedavi bölgesinde RT ye bağlı ayaklarda ve bacaklarda akut dönemde yaygın lenfödem gözlendi. İki (%28,7) bölgede ise ağrı komplikasyonu mevcuttu. Sonuç: RT, KS lezyonlarının palyatif tedavisinde uygun ve etkili bir tedavi rejimidir. RT ile cilt lezyonlarında mü- kemmel cevap oranları elde edilebilir. RT sonrası lezyon- lar ve kaşıntı gibi şikayetler kaybolabilir. Ağrı, ödem gibi yan etkiler destek tedavi ile giderilebilir.

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Cite This Article

TEKE, F., AKKURT, Z. M., TEKE, M., ZİNCİRLİOĞLU, S. B., YILDIRIM, Ö. (2015). Evaluation of 14 patients performed radiotherapy due to Kaposi sarcoma. Dicle Tıp Dergisi, Cilt: 42 - Sayı: 3, 326–330. https://ajindex.com/articles/348852

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