Journals / Kulak Burun Boğaz Uygulamaları / 2017 / Cilt: 5 - Sayı: 3

The effect of topical hemostatic agent ankaferd on the maxillary sinus mucosa

Topikal hemostatik ankaferd ajanının maksiller sinüs mukozasına etkisi

Pages
106–112
DOI
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None of the parameters showed significant difference between the IntactANK and IntactSP groups.Conclusion: While ABS does not increase the fibrosis of the lamina propria for the control group, it reduces the possibility of postoperative synechiae and, increased severity of inflammation, more foreign body reaction, more serous gland loss and ciliary loss may affect the nasal physiology negatively.

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Objective & Hypothesis:Objectives: histopathological effects of ankaferd blood stopper (ABS) in the maxillary sinus.Materials and Methods: We used 33 healthy albino New Zealand rabbits in the study.
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Key Findings & Data:We applied ABS (TrauANK) to the right maxillary sinus of 23 rabbits after mucosal damage was done topically with a curette.
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Conclusion & Impact:None of the parameters showed significant difference between the IntactANK and IntactSP groups.Conclusion: While ABS does not increase the fibrosis of the lamina propria for the control group, it reduces the possibility of postoperative synechiae and, increased severity of inflammation, more foreign body reaction, more serous gland loss and ciliary loss may affect the nasal physiology negatively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: histopathological effects of ankaferd blood stopper (ABS) in the maxillary sinus.Materials and Methods: We used 33 healthy albino New Zealand rabbits in the study. We opened their maxillary sinus surgically. We applied ABS (TrauANK) to the right maxillary sinus of 23 rabbits after mucosal damage was done topically with a curette. After traumatizing the left sinuses of the same rabbits, we applied serum physiologic (TrauSP). We applied ABS (IntactANK) to the right maxillary sinus of 10 rabbits without traumatization and serum physiologic (IntactSP) to their left sinus without traumatization. The rabbits were euthanized at the end of the third week and we performed histopathological examination for the sinus mucosa.Results: Light microscopy of the slides showed increased severity of inflammation, foreign body reaction, serous gland loss, and ciliary loss in the TrauANK compared to the TrauSP group (p=0.003, p<0.001, p<0.01, p<0.001, respectively). There was no significant difference between lamina propriada fibrosis and osteoneogenesis in terms of TrauANK ve TrauSP. None of the parameters showed significant difference between the IntactANK and IntactSP groups.Conclusion: While ABS does not increase the fibrosis of the lamina propria for the control group, it reduces the possibility of postoperative synechiae and, increased severity of inflammation, more foreign body reaction, more serous gland loss and ciliary loss may affect the nasal physiology negatively.

Özet

Amaç: Bu çalışmada maksiller sinüs içine uygulanan ankaferd kan durdurucunun (AKD) histopatolojik etkilerinin tespit edilmesi amaçlandı.Gereç ve Yöntemler: Çalışmamızda 33 sağlıklı albino Yeni Zelanda tavşanı kullanıldı. Cerrahi olarak maksiller sinüsleri açıldı. Yirmi üç tanesinin sağ maksiller sinüsüne topikal olarak küretle mukozal hasar yapıldıktan sonra AKD uygulandı (TravANK). Aynı tavşanların sol sinüslerine de travmatize edildikten sonra serum fizyolojik uygulandı (TravSF). On tavşanın sağ maksiller sinüsüne travmatize etmeden AKD (İntaktANK), sol sinüslerine de travmatize etmeden serum fizyolojik uygulandı (İntaktSF). Üçüncü haftanın sonunda tavşanlar ötenazi edildi ve histopatolojik olarak sinüs mukozaları araştırıldı.Bulgular: Işık mikroskobu ile yapılan ile histopatolojik incelemede, TravANK grubunda TravSF grubuna göre artmış enflamasyon şiddeti, yabancı cisim reaksiyonu, seröz bez kaybı ve silier kayıp gösterildi (sırasıyla, p=0.003, p<0.001, p<0.01, p<0.001). Lamina propriada fibrozis ve osteoneogenez açısından TravANK ve TravSF arasında anlamlı fark izlenmedi. Parametrelerin hiçbiri İntaktANK ve İntaktSF grupları arasında anlamlı bir farklılık göstermedi.Sonuç: Ankaferd kan durdurucunun kontrol grubuna göre lamina propriada fibrozisini artırmaması ameliyat sonrası sineşi yapma olasılığını düşürürken, daha şiddetli enflamasyon, daha çok yabancı cisim reaksiyonu, daha ciddi seröz bez kaybı ve silier kayıp nazal fizyolojiyi olumsuz etkileyebilir.

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Cite This Article

YILDIRIM, B., UĞUR, M. B., ÇORAKÇI, S., EVREN, C., BEKTAŞ, S., ÇINAR, F. (2017). The effect of topical hemostatic agent ankaferd on the maxillary sinus mucosa. Kulak Burun Boğaz Uygulamaları, Cilt: 5 - Sayı: 3, 106–112. https://ajindex.com/articles/346001

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