Journals / Kulak Burun Boğaz İhtisas Dergisi / 2001 / Cilt: 8 - Sayı: 3

The effect of lactate ringer or isotonic NaCl solutions on mucociliary clearance in rat trachea

Laktat ringer ile izotonik NaCl'nin sıçan trakeasında mukosiler klirens hızı üzerine etkileri

Pages
190–193
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The finding that lactate Ringer solution has a more favorable effect on rat mucociliary clearance may be applicable to the nasal mucosa with similar epithelium and mucociliary system, especially in choosing the most appropriate solution for nasal irrigation.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To investigate the effect of lactate Ringer and isotonic NaCl solutions on rat tracheal mucociliary clearance.
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Key Findings & Data:Material and Methotis: Tracheal segments of eight female Wistar Albino rats, measuring approximately 1 cm between the larynx and bifurcation, were removed.
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Conclusion & Impact:Conclusion: The finding that lactate Ringer solution has a more favorable effect on rat mucociliary clearance may be applicable to the nasal mucosa with similar epithelium and mucociliary system, especially in choosing the most appropriate solution for nasal irrigation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Burun mukozası · Tuzlu eriyik · hipertonik

Abstract

Objectives: To investigate the effect of lactate Ringer and isotonic NaCl solutions on rat tracheal mucociliary clearance. Material and Methotis: Tracheal segments of eight female Wistar Albino rats, measuring approximately 1 cm between the larynx and bifurcation, were removed. Each segment was longitudinally divided into two equal portions, and each part was kept either in lactate Ringer or İsotonic NaCl solution for three minutes. Thereafter, carbon particles of same size were placed in the lower ends and their migration was observed for fifteen minutes. The length of particle displacement was measured by means of a dissection microscope. Results: A statistically significant difference was found between the mean distances of particle transportation in segments treated with lactate Ringer solution and isotonic NaCl solution (0.56 mm versus 0.36 mm, p<0.05). Conclusion: The finding that lactate Ringer solution has a more favorable effect on rat mucociliary clearance may be applicable to the nasal mucosa with similar epithelium and mucociliary system, especially in choosing the most appropriate solution for nasal irrigation.

Özet

Amaç: Laktat Ringer ile izotonik NaCl içeren serumların sıçan trakeasının mukosilier klirens hızı üzerine etkilerini araştırmak. Gereç ve Yöntem: Wistar albino cinsi sekiz dişi sıçanın larenks ile bifurkasyon arasındaki trakea segmenti çıkarıldı. Uzunlamasına iki eşit parçaya bölündükten sonra bir parça laktat Ringer, bir parça da izotonik NaCl içeren ortamda üç dakika tutuldu. Daha sonra trakea parçalarının alt uçlarına eşit büyüklüklerde karbon parçaları kondu ve 15 dakika bu şekilde gözlendi. Karbon parçalarının mukosilier sistemle taşınma mesafeleri diseksiyon mikroskobu yardımıyla ölçüldü. Bulgular: Laktat Ringerli solüsyonla yıkanan grupta karbon partikülün mukosilier klirensle taşınma mesafesi ortalama 0.56 mm, izotonik NaCI'li solüsyonla yıkanan grupta ise 0.36 mm ölçüldü. İki grup arasında İstatistiksel olarak anlamlı fark bulundu (p<0.05). Sonuç: Laktat Ringer, izotonik NaCI'ye göre mukosilier klirens üzerine daha olumlu etki yapmaktadır. Bu sonuç klinik olarak, benzer epitel ve mukosilier sisteme sahip nazal mukozada, özellikle de nazal irrigasyon seçiminde kullanılabilir.

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Cite This Article

ÜNAL, M., SEYMEN, H. O. (2001). The effect of lactate ringer or isotonic NaCl solutions on mucociliary clearance in rat trachea. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 8 - Sayı: 3, 190–193. https://ajindex.com/articles/345965