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Journals / Kulak Burun Boğaz Uygulamaları / 2020 / Cilt: 8 - Sayı: 2

Effects of sodium 2-mercaptoethanesulfonate on the nasal mucosa

Sodyum 2-merkaptoetanesulfonatın nazal mukoza üzerindeki etkileri

smail ÇEVİK
Hasan YASAN
İbrahim Metin ÇİRİŞ
Deniz DİLEK
Pages
63–69
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Topical application of mesna on healthy nasal mucosa does not cause nasal mucosa damage.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: This study aims to investigate the topical effects of sodium 2-mercaptoethanesulfonate (mesna) on healthy nasal mucosa.
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Key Findings & Data:Materials and Methods: In this study, conducted between June 2017 and November 2017, used 30 young adult Wistar albino male rats weighing between 240-350 grams.
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Conclusion & Impact:Conclusion: Topical application of mesna on healthy nasal mucosa does not cause nasal mucosa damage.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to investigate the topical effects of sodium 2-mercaptoethanesulfonate (mesna) on healthy nasal mucosa. Materials and Methods: In this study, conducted between June 2017 and November 2017, used 30 young adult Wistar albino male rats weighing between 240-350 grams. Rats were randomized into three groups, with 10 rats in each. No intervention was performed in group 1. Both nasal cavities were washed with distilled water for 14 days in group 2. Both nasal cavities were washed with 100% mesna for 14 days in group 3. All groups were sacrificed on 15th day. Biopsy specimens were stained with hematoxylin-eosin, Masson’s trichrome, Alcian blue and periodic acid-Schiff and evaluated according to the histopathological scoring results. Results: There was no difference between the three groups according to histopathological scoring results. Conclusion: Topical application of mesna on healthy nasal mucosa does not cause nasal mucosa damage.

Özet

Amaç: Bu çalışmada sodyum 2-merkaptoetanesulfonatın(mesna) sağlıklı nazal mukoza üzerindeki topikal etkileriaraştırıldı.Gereç ve Yöntemler: Haziran 2017 - Kasım 2017 tarihleriarasında gerçekleştirilen çalışmada ağırlıkları 240-350 gramarasında değişen 30 Wistar albino genç erişkin erkek sıçankullanıldı. Sıçanlar her birinde 10 sıçan olacak şekilde üç grubarandomize edildi. Grup 1’e herhangi bir işlem uygulanmadı.Grup 2’de her iki nazal kavite 14 gün boyunca distile suylayıkandı. Grup 3’te her iki nazal kavite 14 gün boyunca %100mesna ile yıkandı. Tüm gruplar 15. gün sakrifiye edildi.Biyopsi örnekleri hematoksilen-eozin, Masson trikrom, Alcianmavisi ve periyodik asit-Schiff ile boyandı ve histopatolojikskorlama sonuçlarına göre değerlendirildi.Bulgular: Histopatolojik skorlama sonuçlarına göre üç gruparasında farklılık yoktu.Sonuç: Sağlıklı nazal mukoza üzerine topikal mesnauygulanması nazal mukoza hasarına yol açmamaktadır.

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Cite This Article

ÇEVİK, S., YASAN, H., ÇİRİŞ, İ. M., DİLEK, D. (2020). Effects of sodium 2-mercaptoethanesulfonate on the nasal mucosa. Kulak Burun Boğaz Uygulamaları, Cilt: 8 - Sayı: 2, 63–69. https://ajindex.com/articles/343513

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