Protein Z plazma düzeyleri ile ani işitme kaybı arasında ilişki var mıdır?

Changes in protein Z plasma levels might be associated with arterial thromboembolism or venous thrombosis in patients with sudden sensorineural hearing loss.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to evaluate the relationship between sudden sensorineural hearing loss and protein Z plasma levels.Patients and Methods: Twenty patients with sudden sensorineural hearing loss (14 males; 6 females; mean age 51.6±14.6 years; range 23 to 75 years) and 30 healthy subjects without any hearing problems (14 males, 16 females; mean age 46.8±8.9 years; range 30 to 64 years) were investigated.

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Key Findings & Data:Protein C, protein S, and protein Z plasma levels were measured.Results: When protein S and protein C levels were compared between the study groups, we did not find a statistically significant difference (p=0.78 and p=0.44), whereas, protein Z plasma levels were found to be considerably lower in the sudden sensorineural hearing loss group than in the control group, and the difference was statistically significant (p<0.001).Conclusion: Vascular causes may be involved in the etiology of sudden hearing loss.

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Conclusion & Impact:Changes in protein Z plasma levels might be associated with arterial thromboembolism or venous thrombosis in patients with sudden sensorineural hearing loss.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to evaluate the relationship between sudden sensorineural hearing loss and protein Z plasma levels.Patients and Methods: Twenty patients with sudden sensorineural hearing loss (14 males; 6 females; mean age 51.6±14.6 years; range 23 to 75 years) and 30 healthy subjects without any hearing problems (14 males, 16 females; mean age 46.8±8.9 years; range 30 to 64 years) were investigated. Protein C, protein S, and protein Z plasma levels were measured.Results: When protein S and protein C levels were compared between the study groups, we did not find a statistically significant difference (p=0.78 and p=0.44), whereas, protein Z plasma levels were found to be considerably lower in the sudden sensorineural hearing loss group than in the control group, and the difference was statistically significant (p<0.001).Conclusion: Vascular causes may be involved in the etiology of sudden hearing loss. Changes in protein Z plasma levels might be associated with arterial thromboembolism or venous thrombosis in patients with sudden sensorineural hearing loss.

Özet

Amaç: Bu çalışmada protein Z plazma düzeyleri ile ani işitme kaybı arasında ilişki değerlendirildi.Hastalar ve Yöntemler: Ani işitme kaybı olan 20 hasta (14 erkek, 6 kadın; ort. yaş 51.6±14.6 yıl; dağılım 23-75 yıl) ve herhangi bir işitme sorunu olmayan 30 sağlıklı birey (14 erkek, 16 kadın; ort. yaş 46.8±8.9 yıl; yaş aralığı 30-64 yıl) araştırmaya dahil edildi. Protein C, protein S ve protein Z plazma düzeyleri ölçüldü.Bulgular: Çalışma grupları arasında protein S ve protein C düzeyleri karşılaştırıldığında istatistiksel olarak anlamlı bir fark bulunmazken (p=0.78 ve p=0.44), kontrol grubuna göre ani işitme kaybı olan grupta protein Z plazma düzeylerinin önemli ölçüde düşük olduğu bulundu ve fark istatistiksel olarak anlamlıydı (p<0.001).Sonuç: Damarsal nedenler ani işitme kaybı etyolojisinde yer alabilir. Ani işitme kaybı olan hastalarda protein Z plazma düzeylerindeki değişim arteriyel tromboembolizm veya venöz tromboz ile ilişkili olabilir.

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Cite This Article

ACAR, A., ÖZTÜRK, Z., ÇAYÖNÜ, M., KILINÇ, S. B., TURHAN, T., ÇALCI, E., OĞUZ, O., İRİZ, A. (2016). Protein Z plazma düzeyleri ile ani işitme kaybı arasında ilişki var mıdır?. Kulak Burun Boğaz Uygulamaları, Cilt: 4 - Sayı: 3, 111–116. https://ajindex.com/articles/343447

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