SavedAdd your journal

Journals / Kulak Burun Boğaz İhtisas Dergisi / 2006 / Cilt: 16 - Sayı: 4

The use of serum and nasal eosinophilic cationik protein in the evaluation of the effectivessof immunotherapy in patients with allergic rhinitis

Alerjik rinitli hastalarda serum ve nazal eozinofilik katyönik protenin immunoterapi etkinliğinin değerlendirilmesindeki rolü

Rauf TAHAMİLER
HAYDAR MURAT YENER
Salih ÇANAÇIOĞLU
Pages
155–159
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We conclude that, in addition to the symptoms and clinical findings, nasal ECP measurement may be a reliable and suitable laboratory method to monitor and evaluate the effectiveness of treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: We investigated the use of eosinophilic cationic protein (ECP) as an indicator of clinical efficiency of specific immunotherapy (SIT) in patients with allergic rhinitis sensitive to house dust mites.
📊
Key Findings & Data:Patients and Methods: Specific immunotherapy was administered to 49 patients (20 males, 29 females; mean age 34.2 years; range 16 to 66 years) with perennial allergic rhinitis.
💡
Conclusion & Impact:Conclusion: We conclude that, in addition to the symptoms and clinical findings, nasal ECP measurement may be a reliable and suitable laboratory method to monitor and evaluate the effectiveness of treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Burun mukozası · Testlerin kestirim değeri · Rinit

Abstract

Objectives: We investigated the use of eosinophilic cationic protein (ECP) as an indicator of clinical efficiency of specific immunotherapy (SIT) in patients with allergic rhinitis sensitive to house dust mites. Patients and Methods: Specific immunotherapy was administered to 49 patients (20 males, 29 females; mean age 34.2 years; range 16 to 66 years) with perennial allergic rhinitis. Nasal secretion and serum ECP levels were measured before, at the 6th month of, and two years after completion of, treatment. Comparisons were made within the patient group and with a control group of 16 healthy subjects (10 males, 6 females; mean age 23 years; range 17 to 26 years). Results: Pretreatment nasal ECP levels were significantly higher than those found after the treatment (p<0.001). Nasal ECP levels measured before SIT were significantly different from those of the control group (p<0.05). However, serum ECP levels did not differ significantly between the two groups (p>0.05). Serum ECP levels in the patient group tended to decrease with treatment (p>0.05). Conclusion: We conclude that, in addition to the symptoms and clinical findings, nasal ECP measurement may be a reliable and suitable laboratory method to monitor and evaluate the effectiveness of treatment.

Özet

Amaç: Ev tozu akarlarına duyarlı olan alerjik rinit hastalarında spesifik immünoterapinin (SİT) klinik etkinliğinin bir göstergesi olarak eozinofilik katyonik proteinin (EKP) rolü ve değeri araştırıldı. Hastalar ve Yöntemler: Çalışmaya sürekli alerjik riniti olan 49 hasta (20 erkek, 29 kadın; ort. yaş 34.2; dağılım 16-66) alındı. Hasta grubuna gerekli spesifik immünoterapi uygulandı. Spesifik immünoterapi öncesinde, altıncı ayda ve tedavi bitiminden iki yıl sonra ölçülen nazal sekresyon ve serumdaki EKP seviyeleri hasta grubu içinde ve sağlıklı bireylerden oluşan 16 kişilik (10 erkek, 6 kadın; ort. yaş 23; dağılım 17-26) kontrol grubuyla karşılaştırıldı. Bulgular: Hasta grubunda SİT öncesi nazal EKP seviyeleri tedavi sonrası seviyelere oranla anlamlı derecede yüksek bulundu (p 0.05); ancak hasta grubunda EKP seviyeleri tedaviyle düşme eğilimindeydi. Sonuç: Alerjik rinitin takibi ve uygulanan tedavinin etkinliğini değerlendirmek amacıyla hastaların semptomları ve klinik bulgularının yanı sıra nazal EKP ölçümünün güvenilir ve uygun bir laboratuvar yöntemi olduğu kanısındayız.

🔖

Cite This Article

TAHAMİLER, R., YENER, H. M., ÇANAÇIOĞLU, S. (2006). The use of serum and nasal eosinophilic cationik protein in the evaluation of the effectivessof immunotherapy in patients with allergic rhinitis. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 16 - Sayı: 4, 155–159. https://ajindex.com/articles/343194

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Elberling J, Linneberg A, Dirksen A, Johansen JD, Frolund L, Madsen F, et al. Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. Clin Exp Allergy 2005;35:75-81
  2. Lee CH, Chuang HY, Shih CC, Jee SH, Wang LF, Chiu HC, et al. Correlation of serum total IgE, eosinophil granule cationic proteins, sensitized allergens and family aggregation in atopic dermatitis patients with or without rhinitis. J Dermatol 2004;31:784-93
  3. Woerly G, Loiseau S, Loyens M, Schoch C, Capron M. Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: consequences for allergic eye diseases. Allergy 2003;58:397-406
  4. Czech W, Krutmann J, Schopf E, Kapp A. Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis. Br J Dermatol 1992;126:351-5
  5. Ferguson AC, Vaughan R, Brown H, Curtis C. Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma. J Allergy Clin Immunol 1995;95(1 Pt l):23-8
  6. Venge P. Monitoring the allergic inflammation. Allergy 2004;59:26-32
  7. Bez C, Schubert R, Kopp M, Ersfeld Y, Rosewich M, Kuehr J, et al. Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis. Clin Exp Allergy 2004;34:1079-85
  8. Tutluoğlu B, Gemicioğlu B, Yılmaz N, Küçükusta AR, Kılınç Yılmaz G, Yaman M. Hafif astim ve rinitli olgularda nazal lavaj sivisi eozinofilik katyonik protein ve triptaz değerlerine heparin ve izotonik sodyum klorürün etkisi. Solunum Dergisi 2000;2:36~41
  9. Juhlin L, Venge P. Eosinophilic cationic protein (ECP) in skin disorders. Acta Derm Venereol 1991;71:495-501
  10. Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol 1986; 77:527-37
  11. Marcucci F, Sensi LG, Migali E, Coniglio G. Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma. Allergy 2001;56:231-6
  12. Andersson M, Andersson P, Venge P, Pipkorn U. Eosinophils and eosinophil cationic protein in nasal lavages in allergen-induced hyperresponsiveness: effects of topical glucocorticosteroid treatment. Allergy 1989;44:342-8
  13. Linder A, Venge P, Deuschl H. Eosinophil cationic protein and myeloperoxidase in nasal secretion as markers of inflammation in allergic rhinitis. Allergy 1987; 42:583-90
  14. Bisgaard H, Gronborg H, Mygind N, Dahi R, Lindqvi