Journals / Kulak Burun Boğaz İhtisas Dergisi / 2002 / Cilt: 9 - Sayı: 5

İki olguda nazal natural killer T-hücreli lenfoma

Two cases of nasal natural killer T-cell lymphoma

Pages
376–379
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The importance of obtaining an adequate and deep biopsy sample and employing sophisticated immunohistochemical examination is emphasized for accurate diagnosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Nasal natural killer T-cell lymphoma is a very aggressive and destructive disease with a poor prognosis.
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Key Findings & Data:One patient (age 31 years) had progressive ulceration in the nasal area.
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Conclusion & Impact:The importance of obtaining an adequate and deep biopsy sample and employing sophisticated immunohistochemical examination is emphasized for accurate diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Lenfoma · T-hücreli · Granülom

Abstract

Nasal natural killer T-cell lymphoma is a very aggressive and destructive disease with a poor prognosis. We hereby present two male patients in whom diagnostic problems and a mortal course were encountered. One patient (age 31 years) had progressive ulceration in the nasal area. Two biopsies that had been taken else-where were inconclusive. The other patient (age 40 years) was referred with a previous histopathologic diagnosis of squamous cell carcinoma. He complained of an unhealing wound in the hard palate. Biopsies were repeated in each case. Diagnosis was made by immunohistochemical examination. Both patients died shortly after the diagnosis. The importance of obtaining an adequate and deep biopsy sample and employing sophisticated immunohistochemical examination is emphasized for accurate diagnosis.

Özet

Nazal natural killer T-hücreli lenfoma kötü prognozu olan agresif ve destrüktif bir hastalıktır. Burada hastalığın tanıda zorluklar gösterdiği ve ölümcül süreç izlediği iki olgu sunuldu. İlk olgunun (yaş 31, erkek) burun bölgesinde ilerleyici ülserasyon vardı. Daha önce başka merkezlerde lezyon bölgesinden alınan iki biyopsi sonuç vermemişti. İkinci hasta (yaş 40, erkek) skuamöz hücreli karsinom histopatolojik tanısıyla merkezimize gönderilmişti. Hasta sert damağındaki iyileşmeyen yaradan şikayetçiydi. Her iki olguda da biyopsiler tekrarlandı. Alınan örneklerin immünhistokimyasal yöntemlerle incelenmesiyle tanı konabildi. İki hasta da tanıdan kısa bir süre sonra yaşamını yitirdi. Bu yazıda, doğru tanı için yeterli büyüklükte, derin biyopsi örneği alımının ve modern immünhistokimyasal çalışmaların önemi vurgulandı.

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Cite This Article

IŞIKSAÇAN, V., TOPALOĞLU, İ., BERKİTEN, G., PEKER, K. (2002). İki olguda nazal natural killer T-hücreli lenfoma. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 9 - Sayı: 5, 376–379. https://ajindex.com/articles/342990

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References (6)

  1. Ooi GC, Chim CS, Liang R, Tsang KW, Kwong YL. Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol 2000;174:1141-5
  2. Lee PY, Freeman NJ, Khorsand J, Weinstock MA. Angiocentric T-cell lymphoma presenting as lethal midline granuloma. Int J Dermatol 1997;36:419-27
  3. Vidal RW, Devaney K, Ferlito A, Rinaldo A, Carbone A. Sinonasal malignant lymphomas: a distinct clinicopathological category. Ann Otol Rhinol Laryngol 1999; 108:411-9
  4. Chim CS, Ooi GC, Shek TW, Liang R, Kwong YL. Lethal midline granuloma revisited: nasal T/Naturalkiller cell lymphoma. J Clin Oncol 1999;17:1322-5
  5. Davison SP, Habermann TM, Strickler JG, DeRemeeRA, Earle JD, McDonald TJ. Nasal and nasopharyngeal angiocentric T-cell lymphomas. Laryngoscope 1996;106(2 Pt l):139-43
  6. O'Devaney K, Ferlito A, Hunter BC, Devaney SL, Rinaldo A. Wegener's granulomatosis of the head and neck. Ann Otol Rhinol Laryngol 1998;107(5 Pt l):439-45.