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Journals / KSÜ Tıp Fakültesi Dergisi / 2004 / Cilt: 1 - Sayı: 3

The effects of topically administered östradiol on the healing of anastomosis in the ischemic colon in rats

Ratlarda iskemik kolon segmentinde yapılan anastomozun iyileşmesine topikal uygulanan östradiolün etkisi

İlhami Taner KALE
Serdar BOZKURT
Ertan BÜLBÜLOĞLU
Hüsamettin YÜZER
Fikret EZBERCİ
Pages
87–91
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Topically administered estradiol influences the healing of anastomosis in ischemic colon segment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In this study we assessed the effect of topical estradiol on the healing of ischemic colonic anastomosis.
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Key Findings & Data:Material and methods: A 1 cm segmental resection to the ischemic or non ischemic colon was performed.
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Conclusion & Impact:Conclusion: Topically administered estradiol influences the healing of anastomosis in ischemic colon segment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sıçan · Wistar · Östradiol

Abstract

Objective: In this study we assessed the effect of topical estradiol on the healing of ischemic colonic anastomosis. Material and methods: A 1 cm segmental resection to the ischemic or non ischemic colon was performed. The bowel continuity achived by an end to end anastomosis 5 cm proximal to the anal verge of the rats. Forthy rats were divided into four groups: a transrektal saline group, an ischemia + transrectal saline group, a transrectal estradiol group and an ischemia + transrectal estradiol group. Seven day-old anastomosis were compared for complications, intra abdominal adhesion, bursting pressure and bursting sides. Results: There were more intra abdominal adhesions in ischemic groups. Five animals in ischemia + transrectal saline group and two animals in ischemia + transrectal estradiol group developed anastomotic dehiscence. In the ischemia + transrectal saline group the median bursting pressure was significantly lower from the other groups and more burst occurred from the anastomosis in this group. Conclusion: Topically administered estradiol influences the healing of anastomosis in ischemic colon segment.

Özet

Amac: Bu calışmada iskemik kolon segmentinde yapılan anastomozun iyileşmesine topikal olarak uygulanan ostradiolun etkisini araştırdık. Materyal Metod: Sıçanların bir kısmına sol kolon iskemisi oluşturularak, bir kısmına ise iskemi oluşturulmadan 1 cm'lik segment rezeke edildi, anal çıkımdan 5 cm proksimale ucuca anastomoz yapılarak barsak devamlılığı sağlandı. Kırk adet sıçan transrektal serum fizyolojik(Sf), iskemi + transrektal serum fizyolojik(isk+Sf), transrektal ostradiol (Ost), iskemi + transrektal östradiol (İsk+Öst) olmak üzere 4 gruba ayrıldı. Anastomozlar ameliyat sonrası 7. günde komplikasyonlar, karın içi yapışıklık, patlama basıncı ve patlama yeri açısından karşılaştırıldı. Sonuçlar: İskemik grublarda daha fazla karın içi yapışıklık vardı. İsk+Sf grubunda 5, İsk+Ost grubunda 2 hayvanda anastomoz ayrılması vardı. İsk+Sf grubunun median patlama basınçları diğer gruplardan anlamlı derecede düşüktü ve bu grupta anastomozlar daha çok anastomoz hattından patladı. Sonuç: Topikal olarak uygulanan östradiol iskemik kolon segmentinde yapılan anastomozun iyileşmesine olumlu katkı sağlamaktadır.

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Cite This Article

KALE, İ. T., BOZKURT, S., BÜLBÜLOĞLU, E., YÜZER, H., EZBERCİ, F. (2004). The effects of topically administered östradiol on the healing of anastomosis in the ischemic colon in rats. KSÜ Tıp Fakültesi Dergisi, Cilt: 1 - Sayı: 3, 87–91. https://ajindex.com/articles/342385

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