Journals / MN Kardiyoloji / 2021 / Cilt: 28 - Sayı: 1

Abciximab Induced Thrombocytopenia After Percutaneous Coronary Intervention

Perkütan Koroner Girişim Sonrası Absiksimab Kullanımına Bağlı Gelişen Trombositopeni

Pages
48–48
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We discussed treatment management in two patients who developed abciximab induced thrombocytopenia and bleeding after percutaneous coronary intervention.

📌 3 Key Takeaways

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Objective & Hypothesis:Abciximab is a potent glycoprotein IIb/IIIa (GP IIb/IIIa) receptor inhibitor.
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Key Findings & Data:The major risk factors for thrombocytopenia include age above 65 years, weight less than 80 kilograms and initial platelet count below 200,000.
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Conclusion & Impact:We discussed treatment management in two patients who developed abciximab induced thrombocytopenia and bleeding after percutaneous coronary intervention.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Abciximab is a potent glycoprotein IIb/IIIa (GP IIb/IIIa) receptor inhibitor. It can be used as a bailout therapy in the presence a large thrombus, slow‐ or no‐reflow and other thrombotic complications, shown in angiography. Although it is effective, it has major side ef‐ fects including hypotension, major bleeding and thrombocytopenia. The major risk factors for thrombocytopenia include age above 65 years, weight less than 80 kilograms and initial platelet count below 200,000. Early cessation of the drug is essential and treatment with thrombocyte suspension or intravenous immunoglobulin should be considered. We discussed treatment management in two patients who developed abciximab induced thrombocytopenia and bleeding after percutaneous coronary intervention.

Özet

Absiksimab potent bir glikoprotein IIb/IIIa (GP IIb/IIIa) reseptör inhibitörüdür. Koroner anjiyografi sırasında görülen trombüslerde, yavaşakım ya da no reflow gibi komplikasyonlarda kurtarma tedavisi olarak kullanılabilir. Tedavideki başarısının yanı sıra hipotansiyon, majörkanama ve trombositopeni gibi yan etkileri görülebilir. Hastanın 65 yaşından büyük olması, 80 kilogramın altında olması ve başlangıçtrombosit sayısının 200 binin altında olması trombositopeni için majör risk faktörlerini oluşturur. Trombositopeni gelişen hastalarda te‐davi acil bir şekilde kesilmeli ve gerekirse trombosit süspansiyonu ve intravenöz immünoglobülin tedavisi göz önünde bu lun durulmalıdır.Perkütan koroner girişim sonrasında absiksimaba bağlı trombositopeni ve kanama gelişen iki hastada tedavi yönetimini tartıştık.

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Cite This Article

YALÇINKAYA, D., BOZKURT, U., ÇİÇEK, G., YARLOĞLUEŞ, M. (2021). Abciximab Induced Thrombocytopenia After Percutaneous Coronary Intervention. MN Kardiyoloji, Cilt: 28 - Sayı: 1, 48–48. https://ajindex.com/articles/340942

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