AI Summary & Key Takeaways
AI InsightA Th17 group cytokine, IL-17, correlated with the number of tender joints which is a reflection of the activity of PsA; and IL-22 correlated with sRANKL which is a marker of osteoclastogenesis.
📌 3 Key Takeaways
Abstract
Background: We evaluated Th17 group cytokine profile which is supposed to play an important role in inflammatory diseases, the Wnt pathway which is essential for bone formation and destruction, and parameters of osteoclastogenesis in psoriatic arthritis (PsA) patients. Materials and Methods: We included 48 PsA patients, 20 psoriasis patients and 19 healthy controls into the study. The clinical features of the patients were recorded down from hospital records. A dermatologist evaluated psoriasis area severity index (PASI) scores. ESR, CRP were determined. ELISA was used to determine Th17 group cytokines (IL-17, IL-22, IL-23), Wnt pathway inhibitor DKK-1, and osteoclastogenesis marker soluble RANKL levels. Results: In PsA group, IL-17 levels were significantly lower than in psoriasis and control groups (p values, 0.005 and <0.001). IL-22 levels in the control group were significantly higher than in PsA patients (p=0.001). PsA and psoriasis groups had significantly lower IL-23 levels than controls (p values, respectively, <0.001 and 0.014). The sRANKL level in the control group was significantly higher than in both PsA and psoriasis groups (p values <0.001). Serum DKK-1 levels in all groups were similar. The number of swollen joints in PsA patients correlated with IL-17 (r=053, p<0.001), DKK-1 (r=0.3, p=0.04) and PASI scores (r=0.28, p=0.05). Conclusions: We found lower levels of Th17 cytokines in PsA. A Th17 group cytokine, IL-17, correlated with the number of tender joints which is a reflection of the activity of PsA; and IL-22 correlated with sRANKL which is a marker of osteoclastogenesis.
Özet
Amaç: Psoriatik artritli (PsA) hastalarda inflamatuvar hastal ı klarda önemli rol oynad ı ğ ı dü şünülen T helper 17 grubu sitokin profilini, kemik yapı m ı ve y ı k ı m ı için gerekli olan Wnt yola ğ ı n ı ve osteoklastogenez parametrelerini de ğ erlendirdik. Materyal ve Metot: Çal ı şmaya 48 PsA hastası , 20 psoriazis hastası ve 19 sa ğ l ı kl ı kontrol dahil edildi. Has- talar ı n klinik bulguları hastane kay ı tları ndan elde edildi. Bir dermatolog psoriasis area severity index (PASI) skorları n ı hesaplad ı . ESH, CRP ölçüldü. T helper grubu sitokinler (IL-17, IL-22, IL-23), Wnt yola ğ ı inhibitörü DKK-1, osteoklastogenez belirteci soluble RANKL düzey- leri ELISA ile ölçüldü. Bulgular: PsA grubunda, IL-17 düzeyleri psoriazis ve control gruplar ı ndan anlaml ı dü ş üktü (p de ğ erleri, 0,005 ve <0,001). Kontrol grubundaki IL-22 düzeyleri PsA hastalar ı ndan anlaml ı yüksekti (p=0,001). PsAve psoria- zis gruplar ı n ı n IL-23 düzeyleri kontrollerden anlaml ı dü ş üktü (p de ğ erleri, s ı ras ı yla, <0,001 and 0,014). Kontrol grubundaki sRANKL düzeyi, hem PsA hem de psoriazis grupları ndan anlaml ı yüksekti (p values <0.001). Bütün grupları n serum DKK-1 düzeyleri benzerdi. PsAli hastalardaki ş i ş eklem say ı sı IL-17 (r=0,53, p<0,001), DKK-1(r=0,3, p=0,04), ve PASI skorlar ı yla korreleydi. Sonuç: PsAli hastalarda Th17 grubu sitokinlerin daha dü ş ük oldu ğ unu bulduk. Th17 grubu sitokin olan IL-17, PsAde aktivitenin göstergesi olan hassas eklem say ı - sı yla; ve IL-22 osteoklastogenez belirteci olan sRANKL ile korrele idi.