Journals / Yeni Üroloji Dergisi / 2020 / Cilt: 15 - Sayı: 3

Role of Prostate Specific Antijen in Prostatic Adenocarcinoma Detection in Patients with Benign Prostate Hyperplasia and Were Placed Urethral Catheter After Acute Urinary Retention

Prostat Spesifik Antijenin Akut Üriner Retansiyon Sonrası Üretral Kateter Yerleştirilen ve Benign Prostat Hiperplazisi Olan Hastalarda Prostat Adenokarsinomu Saptamadaki Rolü

Pages
158–163
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For these patients prostate biopsy should be performed only in chosen cases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Acute urinary retension (AUR) is one of the most important complications in benign prostate hyperplasia (BPH) patients and its treatment is generally urethral catheterization in acute period.
📊
Key Findings & Data:There are studies showing that AUR and urethral catheter placement may cause an increase in serum PSA levels.
💡
Conclusion & Impact:For these patients prostate biopsy should be performed only in chosen cases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:acute urinary retention · biopsy · prostate cancer

Abstract

Objective: Acute urinary retension (AUR) is one of the most important complications in benign prostate hyperplasia (BPH) patients and its treatment is generally urethral catheterization in acute period. There are studies showing that AUR and urethral catheter placement may cause an increase in serum PSA levels. Our objective in this study was to investigate the relation between increased PSA levels and prostate cancer (PCa) incidence in the patient group after AUR and urethral catheter placement.Materials and Methods: 77 patients who had an indwelling urethral catheter due to AUR, performed prostate biopsy due to high PSA levels and then surgical treatment for clinic BPH were retrospectively examined. Age, prostate volumes, pre-biopsy total serum PSA and PSA densities were noted. Total serum PSA rates, PSA densities and prostate volumes were compared for the groups that PCa was detected (n=6) and not detected (n=71) according to biopsy or surgical specimen results.Results: Mean age of the patients was 65.2±3.9 years. Mean prostate volume was measured as 64.1±12.8 g, mean serum total PSA level as 9.2±4.2 ng/mL and mean serum PSA density as 0.15±0.08 mg/mL/g. In PSA groups with a serum total PSA level of ≤4.0, 4-10, 10-20 and >20, PCa prevalence rates were detected 0%, 4.3%, 13.4% and 20%, respectively. Total PSA levels and PSA densities were found statistically higher in PCa detected group.Conclusion: PCa incidence is low in patients who were placed urethral catheter after AUR. For these patients prostate biopsy should be performed only in chosen cases.

Özet

Amaç: Akut idrar retansiyonu (AİR) benign prostat hiperplazisi (BPH) hastalarında en önemli komplikasyonlardan biridir ve tedavisi genellikle akut dönemde üretral kateterizasyondur. AİR ve üretral kateter yerleştirilmesinin serum PSA seviyelerinde bir artışa neden olabileceğini gösteren çalışmalar vardır. Bu çalışmada amacımız, AİR sonrası üretral kateter yerleştirilen hasta grubunda artmış PSA düzeyleri ile prostat kanseri (PCa) insidansı arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntemler: AUR nedeniyle kalıcı bir üretral kateteri olan 77 hastada, yüksek PSA seviyeleri nedeniyle yapılan prostat biyopsileri ve daha sonra klinik BPH için yapılan cerrahi tedaviler retrospektif olarak incelendi. Hastaların yaş, prostat hacimleri, biyopsi öncesi total serum PSA ve PSA dansiteleri kaydedildi. Biyopsi veya cerrahi örnek sonuçlarına göre total PSA oranları, PSA dansiteleri ve prostat hacimleri PCa’nın saptandığı (n = 6) ve saptanmadığı (n = 71) gruplar için karşılaştırıldı.Bulgular: Hastaların yaş ortalaması 65.2 ± 3.9 idi. Ortalama prostat hacmi 64.1 ± 12.8 g, ortalama serum total PSA seviyesi 9.2 ± 4.2 ng / mL ve ortalama serum PSA dansitesi 0.15 ± 0.08 mg / mL / g olarak ölçülmüştür. Serum total PSA düzeyi ≤4.0, 4-10, 10-20 ve >20 olan PSA gruplarında PCa prevalansı sırasıyla % 0, % 4,3, % 13,4 ve % 20 olarak tespit edildi. Toplam PSA düzeyleri ve PSA dansiteleri, PCa tespit edilen grupta istatistiksel olarak daha yüksek bulundu.Sonuç: AİR sonrası üretral kateter yerleştirilen hastalarda PCa insidansı düşüktür. Bu hastalar için prostat biyopsisi sadece seçilmiş vakalarda yapılmalıdır.

🔖

Cite This Article

HACIİSLAMOĞLU, A., EVREN, İ., YAVUZSAN, A. H., YİĞİTBAŞI, İ., EKŞİ, M., ŞEKER, K. G., TUĞCU, V. (2020). Role of Prostate Specific Antijen in Prostatic Adenocarcinoma Detection in Patients with Benign Prostate Hyperplasia and Were Placed Urethral Catheter After Acute Urinary Retention. Yeni Üroloji Dergisi, Cilt: 15 - Sayı: 3, 158–163. https://ajindex.com/articles/337117

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. References 1. Bushman W. Etiology, epidemiology, and natural history of benign prostatic hyperplasia. Urol Clin North Am 2009
  2. 403–15. 2. Bosch JL, Hop WC, Kirkels WJ, Schröder FH. The international prostate symptom score in a community-based sample of men between 55 and 74 years of age: prevalence and correlation of symptoms with age, prostate volume, flow rate, and residual urine volume. Br J Urol. 1995
  3. 75(5):622–630. 3. Orsted DD, Bojesen SE, Nielsen SF, Nordestgaard BG. Association of clinical benign prostate hyperplasia with prostate cancer incidence and mortality revisited: a nationwide cohort study of 3,009,258 men. Eur Urol. 2011 Oct
  4. 60(4):691-8.4. Alcaraz A, Hammerer P, Tubaro A, Schröder FH, Castro R. Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review. Eur Urol 2009
  5. 55(4):864–873 5. Schenk JM, Kristal AR, Arnold KB, et al. Association of symptomatic benign prostatic hyperplasia and prostate cancer: results from the prostate cancer prevention trial. Am J Epidemiol 2011, 173(12):1419–1428 6. Simons BD, Morrison AS, Young RH, Verhoek-Oftedahl W. The relation of surgery for prostatic hypertrophy to carcinoma of the prostate. Am J Epidemiol 1999
  6. 138(5):294–300 7. Kefi A, Koseoglu H, Celebi I, Yorukoglu K, Esen A. Relation between acute urinary retention, chronic prostatic inflammation, and accompanying elevated prostate-specific antigen. Scand J Urol Nephrol 2006
  7. 155–60. 8. Shadi Al-Khalil, Christine Ibilibor, James Thomas Cammack, Werner de Riese. Association of prostate volume with incidence and aggressiveness of prostate cancer. Res Rep Urol. 2016
  8. Kravchick S, Bunkin I, Peled R, et al. Patients with elevated serum PSA and indwelling catheter after acute urinary retention: prospective study of 63 patients with 7-year follow-up. J Endourol. 2007 Oct
  9. 21(10):1203-6. 10. Antunes AA, Barbosa JA, Reis ST, et al. Prostate biopsy in patients with long-term use of indwelling bladder catheter: What is the rationale? Urol Oncol. 2012 Sep
  10. 30(5):620-3.11. Lilja H, Ulmert D, Vickers AJ. Prostate-specific antigen and prostatecancer: Prediction, detection, and monitoring. Nat Rev Cancer 2008
  11. 268–78.12. Pienta KJ. Critical appraisal of prostate-specific antigen in prostatecancer screening: 20 years later. Urology 2009
  12. S11–S20.13. Parekh N, Lin Y, Marcella S, Kant AK, Lu-Yao G. Associations of lifestyle andphysiologic factors with prostate-specific antigen concentrat