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Journals / Yeni Üroloji Dergisi / 2023 / Cilt: 18 - Sayı: 1

Efficacy of combination of daily tadalafil and solifenacin in patients with storage symptom predominant lower urinary tract symptoms

Depolama semptomu baskın alt üriner sistem semptomu olan hastalarda günlük tadalafil ve solifenasin kombinasyonunun etkinliği

Ahmet HACİİSLAMOĞLU
Abdullah Hızır YAVUZSAN
Pages
41–47
Publication Date
2023-02-27
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The combination of tadalafil 5mg and solifenacin 5mg daily is an effective and safe treatment for male patients with storage symptoms predominant LUTS/ED.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To evaluate the efficacy of tadalafil 5mg+solifenacin 5mg combination in terms of lower urinary tract symptoms (LUTS) and erectile functions in benign prostate hyperplasia patients with predominant storage symptoms.
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Key Findings & Data:Material and Methods: Male patients over the age of 40 who presented with LUTS with predominant storage symptoms between January 2019 and December 2021 were included into the study.
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Conclusion & Impact:Conclusion: The combination of tadalafil 5mg and solifenacin 5mg daily is an effective and safe treatment for male patients with storage symptoms predominant LUTS/ED.
🔬Design:Survey & Empirical Study
📍Scope:2019 Verileri
⚙️Variables:benign prostat hiperplazisi · depolama · tadalafil

Abstract

Objective: To evaluate the efficacy of tadalafil 5mg+solifenacin 5mg combination in terms of lower urinary tract symptoms (LUTS) and erectile functions in benign prostate hyperplasia patients with predominant storage symptoms. Material and Methods: Male patients over the age of 40 who presented with LUTS with predominant storage symptoms between January 2019 and December 2021 were included into the study. Daily tadalafil 5mg and solifenacin 5mg treatment were started to the patients. Overactive bladder symptom score (OABSS), international prostate symptom score (IPSS) for LUTS, and international erectile function index-erectile function (IIEF-EF) questionnaires were used for erectile function. Frequency of daily urinary frequency, frequency of nocturia, urgency and urinary incontinence were analyzed with a three-day bladder diary. Twelve weeks later, IPSS, OABSS and IIEF-EF scores of the patients were evaluated. Results: When the symptom scores and bladder diaries of the patients before and after 12 weeks of treatment were compared, significant decrease in IPSS scores (both voiding, storage and total) (p<0.001 for each), significant increase in IIEF-EF scores (p<0.001), and significant increase in Qmax value elevation was observed. When the bladder diaries were compared, the number of daytime micturitions, the number of nocturia and the number of urgency decreased in the 12th month after tadalafil+solifenacin treatment (p<0.001). Conclusion: The combination of tadalafil 5mg and solifenacin 5mg daily is an effective and safe treatment for male patients with storage symptoms predominant LUTS/ED.

Özet

Amaç: Depo semptomları baskın olan benign prostat hiperplazi hastalarında tadalafil 5mg+solifenasin 5mg kombinasyonunun alt üriner sistem semptomları (AÜSS) ve erektil fonksiyonlar açısından etkinliğini değerlendirmek. Gereç ve Yöntemler: Ocak 2019 ile Aralık 2021 tarihleri ​​arasında AÜSS ile başvuran ve depolama semptomları baskın olan 40 yaş üstü erkek hastalar çalışmaya dahil edildi. Hastalara günlük tadalafil 5mg ve solifenasin 5mg tedavisi başlandı. AÜSS için aşırı aktif mesane semptom skoru (OABSS), uluslararası prostat semptom skoru (IPSS) ve erektil fonksiyon için uluslararası erektil fonksiyon indeksi-erektil fonksiyon (IIEF-EF) anketleri kullanıldı. Üç günlük mesane günlüğü ile günlük idrar sıklığı, noktüri, sıkışma ve idrar kaçırma sıklığı analiz edildi. On iki hafta sonra hastaların IPSS, OABSS ve IIEF-EF skorları değerlendirildi. Bulgular: Hastaların 12 haftalık tedavi öncesi ve sonrası semptom skorları ve mesane günlükleri karşılaştırıldığında, IPSS skorlarında (hem işeme, hem depolama, hem de toplam) anlamlı azalma (her biri için p<0,001), IIEF-EF skorlarında anlamlı artış ( p<0.001) ve Qmax değer yükselmesinde anlamlı artış gözlendi. Mesane günlükleri karşılaştırıldığında, tadalafil+solifenasin tedavisi sonrası 12. ayda gündüz işeme sayısı, noktüri sayısı ve sıkışma sayısı azaldı (p<0,001). Sonuç: Günde 5 mg tadalafil ve 5 mg solifenasin kombinasyonu, depolama semptomları baskın AÜSS/ED olan erkek hastalar için etkili ve güvenli bir tedavidir.

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Cite This Article

HACİİSLAMOĞLU, A., YAVUZSAN, A. H. (2023). Efficacy of combination of daily tadalafil and solifenacin in patients with storage symptom predominant lower urinary tract symptoms. Yeni Üroloji Dergisi, Cilt: 18 - Sayı: 1, 41–47. https://ajindex.com/articles/889826

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