Journals / Zeynep Kamil Tıp Bülteni / 2013 / Cilt: 44 - Sayı: 3

Maternal and fetal outcomes in preterm premature rupture of membranes

Preterm erken membran rüptürü olan gebelerde maternal ve fetal sonuçlar

Pages
120–126
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

These cases should be monitored and treated in advanced centers which can provide healthcare services in their adult and neonatal intensive care units.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To analyze maternal and fetal outcomes of PPROM (preterm premature rupture of membranes), which is an important and frequent cause of preterm birth, neonatal morbidity and mortality.
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Key Findings & Data:Material and methods: In this study, 94 PPROM patients who had consulted to the Gynecology and Obstetrics Clinics of Dicle University Faculty of Medicine between January 2011 and December 2012 were analyzed retrospectively.
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Conclusion & Impact:These cases should be monitored and treated in advanced centers which can provide healthcare services in their adult and neonatal intensive care units.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To analyze maternal and fetal outcomes of PPROM (preterm premature rupture of membranes), which is an important and frequent cause of preterm birth, neonatal morbidity and mortality. Material and methods: In this study, 94 PPROM patients who had consulted to the Gynecology and Obstetrics Clinics of Dicle University Faculty of Medicine between January 2011 and December 2012 were analyzed retrospectively. Ages, number of gravidas, parities, miscarriages, living children, obstetrical histories, gestational weeks at childbirth, clinical findings, laboratory values, types of deliveries, indications of C-sections, fetal birth weights and fetal lengths and 1.-5. minuteAPGAR scores were assessed. Results: The incidence of PPROM was 3.8 % in our hospital. Mean gestational week at birth and follow-up period of our patients were 31.5±3.1 weeks and 6.1±2.2 days, respectively. Mean C-reactive protein value and White Blood Cell count of our patients on admission were 3.2±4.4 mg/dl and 13626.9±3369.7/mm3, respectively. Steroid therapy was given to 66 (70.2%) patients with gestational age of < 34 weeks so as to achieve fetal pulmonary maturation. Febrile episodes (> 37.5 oC) developed in 14 (14.9%) patients. Growth of E.coli strains was observed in vaginal and cervical cultures of 13 (13.8%) patients. Patients with PPROM were delivered via normal vaginal route (n=51; 54.3%) or cesarean section (n=43; 45.7%). Newborns were brought into observation room (n=48; 51.1%) or neonatal intensive care unit (NICU) (n=46; 48.9%). Fourteen (14.9%) newborns monitored in the NICU died within 24 hours after birth. Five (5.3%) newborns were lost because of sepsis. Mean gestational age of the deceased newborns at delivery was 26.7±1.6 weeks. One- and five minute -APGAR scores increased in parallel with longer gestational weeks of the newborns at birth (r=0.660, p=0.000 and r=0.695, p=0.000, respectively) Conclusion: PPROM is still considered as a prevalent obstetrical complication which leads maternal and/or fetal morbidity and mortality. The patients who seek medical care should be attentively assessed, definitive diagnosis should be absolutely established and patient-specific treatment should be instituted in consideration of all complicating factors of pregnancy predominantly gestational week and infectious manifestations. These cases should be monitored and treated in advanced centers which can provide healthcare services in their adult and neonatal intensive care units.

Özet

Amaç: Preterm doğum, neonatal morbidite ve mortalitenin önemli ve sık bir nedeni olan Prematür Erken Membran Rüptürü (PEMR)’ nün maternal ve fetal sonuçlarının incelenmesi. Materyal Metod: Çalışmada Dicle Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum servisine Ocak 2011-Aralık 2012 tarihleri ara¬sında başvuran PEMR’ li 94 hasta retrospektif olarak incelendi. Hastaların yaşı, gravidası, paritesi, abortus sayısı, yaşayan çocuk sayısı, obstetrik hikayeleri, doğumdaki gebelik haftası, klinik bulguları ve laboratuvar değerleri, doğum şekli, sezeryan endikasyonu, bebeğin doğum ağırlığı ve boyu, 1.-5. dk APGAR skorları irdelendi. Bulgular: Hastanemizde PEMR insidansı 3.8 % idi. Hastalarımızda ortalama doğum haftası 31.5±3.1, izlem süreleri 6.1±2.2 gündü. Hastalarımızın başvuru esnasında C-reaktif protein değeri 3.2±4.4 mg/dl, beyaz küre değerleri 13626.9±3369.7/mm3 idi. Otuzdördüncü gebelik haftasından küçük 66 hastaya (70.2%) fetal akciğer maturasyonu amacıyla steroid uygulandı. Ondört hastada (14.9%) 37,5 oC üzerinde ateş geliştiği gözlendi. Onüç hastada (13.8%) vaginal ve servikal kültürde üreme olduğu ve tamamında E.coli ürediği gözlendi. PEMR olgularında 51 hasta (54.3%) normal doğum ile 43 hasta (45.7%) ise sezaryenle doğurtuldu. Yenidoğanların 48’ i (51,1%) gözleme, 46’ sı (48.9%) yenidoğan yoğun bakıma alındı. Yoğun bakıma alınan 14 (14.9%) yenidoğanın postpartum 24 saat içinde ex olduğu, 5 (5.3%) yenidoğanın sepsis sonrası ex olduğu tespit edildi. Ex olan yenidoğanların ortalama gebelik haftaları (26.7 ±1.6) idi. Gestasyonel hafta arttıkça 1. dk (r = 0.660, p = 0.000) ve 5. dk (r = 0.695, p = 0.000) APGAR değerlerinin arttığı gözlendi. Sonuçlar: PEMR maternal-fetal morbidite ve mortaliteye yol açan ve hala güncelliğini koruyan bir obstetrik problemdir. Başvuran hastalar dikkatli bir şekilde değerlendirilmeli, tanı mutlaka kesinleştirilmeli, gebelik haftası ve enfeksiyon bulguları başta olmak üzere gebeliği komplike edebilecek tüm faktörler göz önünde bulundurularak hastaya özgü uygun tedavi yöntemi uygulanmalıdır. Bu olgular erişkin ve yenidoğan yoğun bakım servisi hizmetinin verildiği ileri merkezlerde takip ve tedavi edilmelidir.

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Cite This Article

TURGUT, A., ÖZLER, A., BAŞARANOĞLU, S., TUNÇ, S. Y., AĞAÇAAYAK, E., GÖRÜK, N. Y., YILDIZBAKAN, A., GÜL, T. (2013). Maternal and fetal outcomes in preterm premature rupture of membranes. Zeynep Kamil Tıp Bülteni, Cilt: 44 - Sayı: 3, 120–126. https://ajindex.com/articles/335489

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