Journals / Zeynep Kamil Tıp Bülteni / 2020 / Cilt: 51 - Sayı: 3

The role of microRNA-124 in early diagnosis, prognosis and treatment of cancer

Kanserin erken teşhisi, prognozu ve tedavisinde mikroRNA-124’ün yeri

Pages
179–185
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Studies on the use of microRNAs as markers have gained momentum in recent years due to the fact that microRNAs can be detected by conventional molecular methods in blood and tissue samples.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Nutrition, lifestyle, genetics, exposure to a carcinogenic substance causing cancer is one of the common causes of death.
📊
Key Findings & Data:MicroRNAs are included in the non-coding RNA groups containing about 25 nucleotides and discovered over the last 25 years, which are considered to be one of these biomarkers.
💡
Conclusion & Impact:Studies on the use of microRNAs as markers have gained momentum in recent years due to the fact that microRNAs can be detected by conventional molecular methods in blood and tissue samples.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:mir-124 · kanser · mikroRNA

Abstract

Nutrition, lifestyle, genetics, exposure to a carcinogenic substance causing cancer is one of the common causes of death. Especially in recent years some of the studies to reduce cancer mortality have focused on biomarkers that will provide early detection. MicroRNAs are included in the non-coding RNA groups containing about 25 nucleotides and discovered over the last 25 years, which are considered to be one of these biomarkers. Studies on the use of microRNAs as markers have gained momentum in recent years due to the fact that microRNAs can be detected by conventional molecular methods in blood and tissue samples.

Özet

Beslenme, yaşam tarzı, genetik, kanserojen bir maddeye maruziyet gibi sebeplerle ortaya çıkan kanser yaygın ölüm nedenlerinden biridir. Kanser mortalitesini azaltmak için yapılan çalışmalardan bir kısmı son yıllarda özellikle erken teşhisi sağlayacak biyobelirteçler üzerine yoğunlaşmıştır. Bu biyobelirteçlerden biri olarak değerlendirilen mikroRNA’lar, son 25 yıl içerisinde keşfedilmiş yaklaşık 25 nükleotid uzunluğunda kodlanmayan RNA grubuna dâhildir. Kan ve doku örneklerinden geleneksel moleküler yöntemlerle tespit edilebiliyor oluşları sayesinde mikroRNA’ların belirteç olarak kullanılmasına yönelik çalışmalar son yıllarda hız kazanmıştır.

🔖

Cite This Article

ÇAYKARA, B., ÖZTÜRK, G. (2020). The role of microRNA-124 in early diagnosis, prognosis and treatment of cancer. Zeynep Kamil Tıp Bülteni, Cilt: 51 - Sayı: 3, 179–185. https://ajindex.com/articles/335383

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Torre LA, Bray F, Siegel RL et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87-108. doi: 10.3322/caac.21262
  2. Clapp RW, Jacobs MM, Loechler EL. Environmental and occupational causes of cancer: new evidence 2005-2007. Rev Environ Health. 2008;23(1):1-37
  3. Del Chiaro M, Segersvärd R, Lohr M, Verbeke C. Early detection and prevention of pancreatic cancer: is it really possible today? World J Gastroenterol. 2014;20(34):12118-31. doi: 10.3748/wjg.v20.i34.12118
  4. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136: 215-233. doi: 10.1016/j.cell.2009.01.002
  5. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843-854
  6. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009;10:704-714. doi: 10.1038/nrg2634
  7. Redova M, Poprach A, Nekvindova J et al. Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma. J Transl Med. 2012;10:55. doi:10.1186/1479-5876-10-55
  8. Silva-Santos RM, Costa-Pinheiro P, Luis A et al. MicroRNA profile: a promising ancillary tool for accurate renal cell tumour diagnosis. Br J Cancer. 2013;109(10):2646-53. doi:10.1038/bjc.2013.552
  9. Li M, Wang Y, Song Y et al. MicroRNAs in renal cell carcinoma: a systematic review of clinical implications (Review). Oncol Rep. 2015;33(4):1571-8. doi: 10.3892/or.2015.3799
  10. Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003 Dec 15;17(24):3011-6
  11. Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol. 2007;302(1):1-12
  12. Mulrane L, McGee SF, Gallagher WM, O'Connor DP. miRNA dysregulation in breast cancer. Cancer Res. 2013;73(22):6554-62. doi:10.1158/0008-5472.CAN-13-1841
  13. Winter J, Jung S, Keller S et al. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009;11(3):228-34. doi: 10.1038/ncb0309-228
  14. Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell. 2007;27:435–448
  15. Furuta M, Kozaki KI, Tanaka S et al. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis. 2010;31(5):766-76. doi: 10.1093/carcin/bgp250
  16. Ando T, Yoshida T, E