Journals / Zeynep Kamil Tıp Bülteni / 2020 / Cilt: 51 - Sayı: 3

Early Results of Newborns Affected by Twin to Twin Transfusion Syndrome

İkizden İkize Transfüzyon Sendromundan EtkilenmişYenidoğanların Erken Dönem Sonuçları

Pages
128–132
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Twenty-one cases were discharged with healing.Conclusion: Close follow-up of twin pregnancies, prevention of preterm birth and awareness of TTTS specific problems en-countered by babies with TTTS are vital for these babies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to evaluate the results of neonatal period of infants affected by twin-to-twin transfusion syndrome (TTTS), which may lead to serious life-threatening complications in monochorionic multiple pregnancies.Material and Methods: The demographic and clinical data of the cases diagnosed with TTTS in our clinic between January 2013 and December 2017 were evaluated retrospectively.Results: Thirty-one infants born to 18 twin pregnancies who developed TTTS were delivered alive.
📊
Key Findings & Data:Seventeen ca-ses were recipient and 14 were donor twins.
💡
Conclusion & Impact:Twenty-one cases were discharged with healing.Conclusion: Close follow-up of twin pregnancies, prevention of preterm birth and awareness of TTTS specific problems en-countered by babies with TTTS are vital for these babies.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to evaluate the results of neonatal period of infants affected by twin-to-twin transfusion syndrome (TTTS), which may lead to serious life-threatening complications in monochorionic multiple pregnancies.Material and Methods: The demographic and clinical data of the cases diagnosed with TTTS in our clinic between January 2013 and December 2017 were evaluated retrospectively.Results: Thirty-one infants born to 18 twin pregnancies who developed TTTS were delivered alive. One fetus of four twin couples had died in intrauterine period. Four pregnant women underwent laser photocoagulation, the two donor twins of the-se pregnancies died during intrauterine period. Seventeen ca-ses were recipient and 14 were donor twins. The birth weights of the cases were 1346±654 grams and the gestational weeks were 30.1±3.7 weeks. Hydrops were detected in two cases. The hemoglobin and hematocrit values of donor twins were signifi-cantly lower; mortality rates were significantly higher than the recipient twins (p = 0.0001;0.0001;0.018, respectively). Exc-hange transfusion was done to two patients for anemia and six patients for polycythemia. No significant difference was found between donor and recipient twins in terms of birth weight, res-piratory distress syndrome, patent ductus arteriosus, broncho-pulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis; respiratory support and inotropic need. Cardiac hypertrophy was detected in three of the recipient cases. One recipient and three donor cases developed renal failure. Four donor cases, one recipient case were lost. Twenty-one cases were discharged with healing.Conclusion: Close follow-up of twin pregnancies, prevention of preterm birth and awareness of TTTS specific problems en-countered by babies with TTTS are vital for these babies.

Özet

Amaç: Monokoryonik çoğul gebeliklerde gelişen ve hayatı tehdit eden ciddi komplikasyonlara yol açabilen ikizden ikize transfüzyon sendromu (İİTS)’ndan etkilenmiş infantların yeni-doğan dönemi sonuçlarının değerlendirilmesi amaçlanmıştır.Gereçler ve Yöntem: Kliniğimizde Ocak 2013- Aralık 2017 tarihleri arasında izlenen İİTS tanılı olguların demografik ve klinik verileri geriye dönük değerlendirildi.Bulgular: Belirlenen sürede İİTS gelişen 18 ikiz gebelikten 31 bebeğin canlı olarak doğurtulduğu görüldü. Dört ikiz eşi intrauterin dönemde kaybedilmişti. Dört gebeye lazer fotoko-agulasyon uygulanmış ve bu gebeliklerden ikisinde verici ikiz intrauterin dönemde kaybedilmişti. Olguların 17’si alıcı, 14’ü verici ikizdi. Olguların doğum tartıları 1346±654 gram, ge-belik haftaları 30,1±3,7 hafta idi. İki olguda hidrops fetalis saptandı. Verici ikizlerin hemoglobin ve hematokrit değerleri alıcı ikizlere göre anlamlı olarak daha düşük; ölüm oranları ise anlamlı olarak daha yüksek saptandı (sırasıyla p=0,0001; 0,0001; 0,018). İki olguya anemi, altı olguya polisitemi nedeni ile kan değişimi yapıldı. Alıcı ve verici ikizler arasında doğum tartıları, respiratuvar distres sendromu, patent duktus arteri-osus, bronkopulmoner displazi, prematürite retinopatisi ve nekrotizan enterokolit gelişimi; solunum desteği ve inotrop ihti-yacı açısından anlamlı fark saptanmadı. Alıcı olguların üçünde kardiak hipertrofi saptandı. Bir alıcı ve üç verici olguda böbrek yetmezliği gelişti. Verici olguların dördü, alıcı olguların biri kaybedildi. Yirmi bir olgu şifa ile taburcu edildi.Sonuç: İkiz gebeliklerin yakın takibi, erken doğumun önlenmesi ve İİTS tanılı bebeklerin karşılaşacağı İİTS’ye özgü sorunların farkında olunması bu bebekler için hayati önem taşımaktadır.

🔖

Cite This Article

OKBAY, A. G., TOPÇUOĞLU, S., KARADAĞ, N., ÖZALKAYA, E., KARATEKİN, G. (2020). Early Results of Newborns Affected by Twin to Twin Transfusion Syndrome. Zeynep Kamil Tıp Bülteni, Cilt: 51 - Sayı: 3, 128–132. https://ajindex.com/articles/335126

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Bliss JM, Carr SR, De Paepe ME, Luks FI. What—andWhy—the Neonatologist Should Know About Twin-To-Twin Transfusi-on Syndrome. Neo Reviews 2017; 18: 22-32
  2. Emery SP, Hasley SK, Catov JM, Miller RS, Moon-Grady AJ, Baschat AA, et al. North American Fetal Therapy Network. North American Fetal Therapy Network: intervention vs expe-ctant management for stage I twin-twin transfusion syndrome. Am J Obstet Gynecol 2016; 215: 1-7
  3. Hecher K, Diehl W, Zikulnig L, Vetter M, Hackelöer BJ. En-doscopic laser coagulation of placental anastomoses in 200 pregnancies with severe mid-trimester twin-to-twin transfusion syndrome. Eur J Obstet Gynecol Reprod Biol 2000; 92: 135-9
  4. Quintero RA, Morales WJ, Allen MH, Bornick PW, Johnson PK, Kruger M. Staging of twin-twin transfusion syndrome. J Perinatol 1999; 19: 550-5
  5. Slaghekke F, Kist WJ, Oepkes D, Middeldorp JM, Klumper FJ, Vandenbussche FP, et al. TAPS and TOPS: two distinct for-ms of feto-fetal transfusion in monochorionic twins. Z Geburts-hilfe Neonatol 2009; 213: 248-54
  6. Chmait RH, Quintero RA. Operativefetoscopy in complicated monochorionic twins: current status and future direction. Curr Opin Obstet Gynecol 2008; 20: 169-74
  7. De Paepe ME, Stopa E, Huang C, Hansen K, Luks FI. Renal tubular apoptosis in twin-to-twin transfusion syndrome. Pedi-atr Dev Pathol 2003; 6: 215-25
  8. SenatMV, Deprest J, Boulvain M, PaupeA,Winer N, Ville Y. Endoscopic laser surgery versus serial amnioreduction for se-vere twin-to-twin transfusion syndrome. N Engl J Med 2004; 351: 136-44
  9. Khalek N, Johnson MP, Bebbington MW. Fetoscopic laser therapy for twin-to-twin transfusion syndrome. Semin Pediatr Surg 2013; 22: 18-23
  10. De Paepe ME, Friedman RM, Poch M, Hansen K, Carr SR, Luks FI. Placental findings after laser ablation of communica-ting vessels in twin-to-twin transfusion syndrome. Pediatr Dev Pathol 2004; 7: 159-65
  11. Muratore CS, Carr SR, Lewi L, Delieger R, Carpenter M, Jani J, et al. Survival after laser surgery for twin-to-twin trans-fusion syndrome: when are they out of the woods? J Pediatr Surg 2009; 44: 66-9
  12. Rossi AC, Vanderbilt D, Chmait RH. Neurodevelopmental outcomes after laser therapy for twin-twin transfusion synd-rome: a systematic review and meta-analysis. Obstet Gynecol 2011; 118: 1145-50 13. Kowitt B, Tucker R, Watson-Smith D, Muratore CS, O'Brien BM, Vohr BR, et al. Long-term morbidity after fetal endoscopic surgery for severe twin-to-twin transfusion syndrome. J Pediatr Surg 2012; 47: 51-6. 14