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Journals / Van Tıp Dergisi / 2000 / Cilt: 7 - Sayı: 1

Serum arginase activity in cancer

Kanserde serum arginaz aktivitesi

İclal MERAM
Sibel AHİ
Mehmet TARAKÇIOĞLU
Pages
20–23
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

While the control group did not show any correlation, the group of cancer exhibited a positive relation between the level of BUN and arginase activity (r=0.48, p<0.05).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study; the serum arginase activity of 24 cancer patients was determined by Thiosemicarbazide diacetyl monoxime urea method.
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Key Findings & Data:The serum arginase activity of cancer patients was found significantly higher (14.9± 9.2 $µmol urea/ g.protein/ h) than control group value (4.9± 3.8 µmol urea/ g.protein/ h) (p<0.001).
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Conclusion & Impact:While the control group did not show any correlation, the group of cancer exhibited a positive relation between the level of BUN and arginase activity (r=0.48, p<0.05).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Arginaz · Üre · Biyokimya

Abstract

In this study; the serum arginase activity of 24 cancer patients was determined by Thiosemicarbazide diacetyl monoxime urea method. In addition, the serum levels of blood urea nitrogen (BUN), creatinine, total protein, albumin, alkaline phosphatase were measured. The serum arginase activity of cancer patients was found significantly higher (14.9± 9.2 $µmol urea/ g.protein/ h) than control group value (4.9± 3.8 µmol urea/ g.protein/ h) (p<0.001). Although the levels of total protein, albumin were obtained lower than normal group values respectively, (p<0.01, p<0.001), the level of creatinine was found higher than normal group value (p<0.05). As a result, paralel to the increased levels at creatinine, total protein and albumin, serum arginase activity was high as well. When we analyzed the correlation between serum arginase activity and other parameters. While the control group did not show any correlation, the group of cancer exhibited a positive relation between the level of BUN and arginase activity (r=0.48, p<0.05).

Özet

Bu çalışmada 24 kanserli hastanın serum arginaz aktivitesi Tiyosemikarbazid diasetil monoksim üre yöntemi ile ölçülmüştür. Ek olarak kanserli hastaların serum kan üre azotu, kreatinin, total protein, albumin, alkalen fosfataz düzeyleri ölçülmüş ve enzim aktivitesinin (14.9± 9.2 $µmol üre/g.protein /saat) kontrol olgularından belirgin olarak daha yüksek olduğu görülmüştür (4.9± 3.8 $µmol üre/g.protein/saat) (p<0.001). Serum total protein, albumin düzeylerinde önemli düşme gözlenirken sırasıyla (p<0.01, p<0.001), kreatinin düzeylerinde ise önemli artış bulunmuştur (p<0.05). Sonuç olarak; serum arginaz aktivitesinin kanserli olgularda kreatinin gibi yükseldiği, total protein ve albumin düzeylerinin ise azaldığı kanısına varılmıştır. Serum arginaz aktivitesi ile diğer parametreler arasındaki korelasyon sonuçları incelendiğinde, kontrol grubunda ilişki gözlenmezken, kanserli grupta kan üre azotu düzeyi ile arginaz aktivitesi arasında pozitif bir korelasyon bulunmuştur (r = 0.48, p<0.05).

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Cite This Article

MERAM, İ., AHİ, S., TARAKÇIOĞLU, M. (2000). Serum arginase activity in cancer. Van Tıp Dergisi, Cilt: 7 - Sayı: 1, 20–23. https://ajindex.com/articles/334664

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