AI Summary & Key Takeaways
AI InsightConclusion: It was observed that the decoction extract of Secale cereale L. has significantly lower effect (weak hypoglycemic effect lasting for nearly four hours) when compared with glibenclamide which was used as a reference agent.
📌 3 Key Takeaways
Abstract
Aim: Investigation of the hypoglycemic effect of secale cereale L. fruit decoction extract in healthy antf diabetic mice. Method: Extract of Secale cereale L., glibenclamide (as a reference group) and physiologic saline (control group) were administrated perorally to the healthy and diabetic mice induced with alloxan. Before treatment,at the first, second, third, fourth and 24th hours, blood was taken from the vena coccygea of mice and Blood glucose levels were measured. Results were tested by One-way ANOVA. Results: When compared with physiologic saline group, it was observed that Secale cereale L. extract decreased blood glucose values significantly in diabetic mice induced with alloxan at the first (p<0,05) and second hour (p<0,01), this effect was not observed at the fourth and 24th hour. Glibenclamide decreased blood glucose values significantly at the first, second and fourth hours (p<0,001); this effect was disappeared at the 24th hour. When compared with Secale cereale L., it was observed that glibenclamide decreased blood glucose values more significantly at the first, second and fourth hours (p<0,001), there was not significant difference between tjyo groups (p>0,0S) at the 24th hour. There was not significant difference in blood glucose values measurements among groups of healthy mice. Conclusion: It was observed that the decoction extract of Secale cereale L. has significantly lower effect (weak hypoglycemic effect lasting for nearly four hours) when compared with glibenclamide which was used as a reference agent.
Özet
Amaç: Secale cereale L. (çavdar) meyvesi dekoksiyon ekstresinin, sağlıklı ve diyabetli farelerde hipoglisemik etkisinin araştırılması. Yöntem: Alloksanla diyabet oluşturulmuş farelere ve sağlıklı farelere Secale cereale L. ekstresi, glibenclamide (referans) ve serum fizyolojik (kontrol) oral yolla verilip; sıfırıncı, birinci, ikinci, dördüncü ve 24. saatlerde, farelerin kuyruk veninden kan alınarak açlık kan şekeri düzeyleri ölçüldü; sonuçlar tek yönlü varyans analizi ile test edildi. Bulgular: Secale cereale L. ekstresinin; alloksanla diyabet oluşturulmuş farelerde serum fizyolojik grubuna göre açlık kan şekerini birinci saatte (p 0.05); glibenclamidein, serum fizyolojik grubuna göre açlık kan şekerini birinci, ikinci ve dördüncü saatlerde anlamlı derecede düşürdüğü (p 0.05); glibenclamide'in, Secale cereale L.'ye göre açlık kan şekerini birinci ve ikinci saattlerde p 0.05). Sağlıklı farelerde gruplar arasında açlık kan şekeri yönünden yapılan ölçümlerde anlamlı bir fark saptanmamıştır. Sonuç: Secale cereale L. meyvesi dekoksiyon ekstresinin, referans ilaç olarak kullanılan glibenclamideden anlamlı derecede düşük düzeyde, yaklaşık dört saat süren zayıf bir hipoglisemik etki gösterdiği gözlendi.