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Journals / European Journal of Biology / 2008 / Cilt: 67 - Sayı: 1

The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study

Şehnaz BOLKENT
Özlem SAÇAN
Ayşe KARATUĞ
Refiye YANARDAĞ
Pages
1–7
Publication Date
2010-11-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, all of the obtained morphological and biochemical findings led to the conclusion that vitamin B6 has a protective effect against diabetes mellitus.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of present study was to investigate the morphological and biochemical effects of vitamin B6 on liver tissue of normal and streptozotocin-diabetic rats.
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Key Findings & Data:Experimental diabetes was induced by intraperitonal injection of streptozotocin (STZ) in a single dose of 65 mg/kg.
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Conclusion & Impact:As a result, all of the obtained morphological and biochemical findings led to the conclusion that vitamin B6 has a protective effect against diabetes mellitus.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of present study was to investigate the morphological and biochemical effects of vitamin B6 on liver tissue of normal and streptozotocin-diabetic rats. Experimental diabetes was induced by intraperitonal injection of streptozotocin (STZ) in a single dose of 65 mg/kg. Vitamin B6 was administered by subcutaneous injection at a dose of 20 mg/kg for 15 days. The degenerative changes in the liver tissue, biochemical changes in blood glucose levels and in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) activities were determined. Degenerative changes observed in the diabetic animals by light microscopic investigations. Blood glucose levels, serum AST, ALT and ALP activities increased in the diabetic group. On the other hand, the treatment with vitamin B6 for 15 days reversed these effects. As a result, all of the obtained morphological and biochemical findings led to the conclusion that vitamin B6 has a protective effect against diabetes mellitus.

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Cite This Article

BOLKENT, Ş., SAÇAN, Ö., KARATUĞ, A., YANARDAĞ, R. (2010). The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study. European Journal of Biology, Cilt: 67 - Sayı: 1, 1–7. https://ajindex.com/articles/33338

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References (9)

  1. Baynes J. W. and Thorpe S. R. (1999) Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes, 48: 1-9.
  2. Bennink H. J. and Schreurs W. H. (1975) Improvement of oral glucose tolerance in gestational diabetes by pyridoxine. British Medicine Journal, 3: 13–15.
  3. Borschel M. W., Kirksey A. and Hanneman R. E. (1986) Effects of vitamin B6 intake on nutriture and growth of young infants. American Journal of Clinical Nutrition, 43: 7 – 15. Coburn S. P. (1994) A critical review of minimal vitamin B6 requirements for growth in various species with a proposed method of calculation. Vitamins and Hormones, 48: 259 – 300. Ellis J. M., Folkers K., Minadeo M., Vanbuskirk R., Xia L. J. and Tamagawa H. (1991) A deficiency of vitamin B6 is a plausible molecular basis of the retinopathy of patients with diabetes mellitus. Biochemical and Biophysical Research Communications, 179: 615–619.
  4. Jain S. K. (2007) Vitamin B6 (pyridoxamine) supplementation and complications of diabetes. Metabolism Clinical and Experimental. 56: 168- 171. Koyuturk M., Tunalı S. Bolkent S. and Yanardag R. (2005) Effects of vanadyl sulfate on liver of Streptozotocin-induced diabetic rats. Biological Trace Element Research, 104: 2332-2347.
  5. Nanbara S., Tanaka K., Koide H., Tanaka T. and Hayashi T. (1990) Changes on levels of B6 vitamin and aminotransferase in the liver of diabetic animals. Diabetes Research and Clinical Practice, 9: 109–114.
  6. Okada M., Harima H., Hosoi Y. and Sogo A. (1993) Influences of some low molecular compounds on enzymatic activity and isoelectric point of aspartate aminotransferase from rat liver. Journal Vitaminology, 39: 311–321.
  7. Science and Okada M., Miyamoto E., Nishida T., Tomida T. and Shibuya M. (1997) Effect of vitamin B-6 nutrition metabolism. Biochemistry, 8: 44 –48. on vitamin B-6 The Journal of Nutritional Okada M., Shibuya M., Yamamoto E. and Murakami Y. (1999) Effects of diabetes on vitamin B6 requirement in experimental animals. Diabetes, Obesity and Metabolism, 1: 221-225.
  8. Rall L. C. and Meydani S. N. (1993) Vitamin B6 and immune competence. Nutrition, Reviews, 51: 217 – 225. Ravi K., Ramachandran B. and Subramanian S. (2004) Protective effect of Eugenia jambolana seed streptozotocin–induced diabetic rats. Biological Pharmaceutical Bulletin, 27: 1212-1217.
  9. Ravichandran V. and Selvam R. (1991) Increased plasma lipid peroxidation in vitamin B-6 deficient rats. Indian Journal of Experimental Biology, 29: 56–58. Reitman S. and Frankel