Journals / Viral Hepatitis Journal / 2014 / Cilt: 20 - Sayı: 1

Adana İlinde Kronik Hepatit C’nin Değişen Epidemiyolojisi

Changing Epidemiology of Chronic Hepatitis C in Adana

Pages
15–18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Decrease in the mean age of the patients, higher probability of occurrence among males and increased rates of genotype 2 and 3 were associated with this reason.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Our study aimed to demonstrate the epidemiological data of hepatitis C virus (HCV) and changes in its genotypic distribution which was observed in Adana in time.
📊
Key Findings & Data:Materials and Methods: The data from 369 patients who were on follow up with the diagnosis of chronic hepatitis C between January 1996 and March 2013, were reviewed retrospectively.
💡
Conclusion & Impact:Decrease in the mean age of the patients, higher probability of occurrence among males and increased rates of genotype 2 and 3 were associated with this reason.
🔬Design:Review & Systematic Survey
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Our study aimed to demonstrate the epidemiological data of hepatitis C virus (HCV) and changes in its genotypic distribution which was observed in Adana in time. Materials and Methods: The data from 369 patients who were on follow up with the diagnosis of chronic hepatitis C between January 1996 and March 2013, were reviewed retrospectively. The differences between the gender, age, and routes of transmission among the HCV patients with different genotypes were reviewed. Changes in the mean age, gender, and virus genotypes of the patients in our region by the years were evaluated. Results: Genotype 1 was identified in 289 (78.3%) patients, genotype 2 in 23 (6.2%) patients, genotype 3 in 54 (14.6%) patients and genotype 4 was identified in 3 (0.8%) patients. When the genotypic distribution over the years was assessed, the rate of the patients with genotype 2 or 3 was 2.7% between 1996 and 2008, this rate was observed to increase to 44% between 2012 and 2013. Sixty nine out of 77 (89.6%) patients with genotype 2 or 3 were intravenous drug addicts. Conclusion: In our region intravenous drug use-related HCV infection was increased in recent years. Decrease in the mean age of the patients, higher probability of occurrence among males and increased rates of genotype 2 and 3 were associated with this reason.

Özet

Amaç: Bu çalışmada, Adana ilinde zaman içinde ortaya çıkan hepatit C virüsü (HCV) nün epidemiyolojik verileri ve genotip dağılımındaki değişikliklerin gösterilmesi amaçlanmıştır. Gereç ve Yöntemler: Kronik hepatit C tanısıyla, Ocak 1996-Mart 2013 tarihleri arasında takip edilen 369 hastanın verileri retrospektif olarak değerlendirilmiştir. Çalışmada, farklı genotipe sahip hastalar arasındaki cinsiyet, yaş ve bulaş yolu farklılıkları ve yıllara göre bölgemizdeki hastaların yaş ortalaması, cinsiyetleri ve virüs genotiplerindeki değişimler ele alınmıştır. Bulgular: Genotip 1, 289 (%78,3) hastada; genotip 2, 23 (%6,2) hastada; genotip 3, 54 (%14,6) hastada; genotip 4 ise 3 (%0,8) hastada tespit edildi. Yıllara göre genotip dağılımı incelendiğinde; 1996-2008 yılları arasında genotip 2 ve 3’e sahip hastaların oranı %2,7 iken, 2012-2013 yılları arasnda bu oranın %44’e yükseldiği görüldü. Genotip 2 veya 3’e sahip 77 hastanın 69 (%89,6)’sında intravenöz ilaç bağımlılığı vardı. Sonuç: Son yıllarda damar içi ilaç kullanımına bağlı HCV enfeksiyonu bölgemizde artış göstermiştir. Hastaların yaş ortalamasındaki düşüş, erkek cinsiyette daha sık görülür olması ve genotip 2 ve 3 oranlarındaki artış bu nedene bağlanmıştır.

🔖

Cite This Article

KUŞCU, F., KÖMÜR, S., İNAL, A. S., ULU, A. C., KURTARAN, B., TAŞOVA, Y., ÜNLÜ, B., MIDIKLI, D., TOMUL, Z. D., YILMAZ, G., MUTAY, B. S., AKSU, H. S. Z. (2014). Adana İlinde Kronik Hepatit C’nin Değişen Epidemiyolojisi. Viral Hepatitis Journal, Cilt: 20 - Sayı: 1, 15–18. https://ajindex.com/articles/332815

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. shepard cW, Finelli L, Alter MJ. Global epidemiology of hepatitis c virus infection. Lancet Infect Dis. 2005; 5: 558-567
  2. Barut HŞ, Günal ö. Global and national epidemiology of hepatitis c. Klimik Journal. 2009; 22: 38-43
  3. Argentini c, Genovese D, Dettori s, rapicetta M. HcV genetic variability: from quasispecies evolution to genotype classification. Future Microbiol. 2009; 4: 359-373
  4. Abacioglu YH, Davidson F, Tuncer s, Yap PL, ustacelebi s, Yulug n, simmonds P. The distribution of hepatitis c virus genotype in Turkish patients. J Viral Hepat 1995; 2: 297-301. 5. çiftçi İH, er H, Aşık G, Aktepe Oc, Altındiş M. The distribution of genotype of the hepatitis c virus (HcV) rnA positive patients. 2009:10: 21-24
  5. Keskin F, çiftçi s, Türkoğlu s, Badur s. Transmission routes of chronic hepatitis c and their relation to HcV genotypes. Turk J Gastroenterol. 2010; 21: 396-400
  6. Ozbek e, Ozekinci T, Mese s, Atmaca s. Hepatitis c virus genotypes are changing in the southeast of Turkey. Biotechnol Biofuels. 2009; 23: 1521-1523. 8. esteban JI, sauleda s, Quer J. The changing epidemiology of hepatitis c virus infection in europe. J Hepatol. 2008; 48: 148- 162. 9. cornberg M1, razavi HA, Alberti A, Bernasconi e, Buti M, cooper c, Dalgard O, Dillion JF, Flisiak r, Forns X, Frankova s, Goldis A, Goulis I, Halota W, Hunyady B, Lagging M, Largen A, Makara M, Manolakopoulos s, Marcellin P, Marinho rT, Pol s, Poynard T, Puoti M, sagalova O, sibbel s, simon K, Wallace c, Young K, Yurdaydin c, zuckerman e, negro F, zeuzem s. A systematic review of hepatitis c virus epidemiology in europe, canada and Israel. Liver Int. 2011; 31(suppl 2): 30-60
  7. Yarkın F, Hafta A. The distribution of hepatitis c virus (HcV) genotypes in patients with chronic hepatitis c infection. Viral Hepatitis Journal. 2000; 6: 164-168
  8. Tezcan s1, ulger M, Aslan G, Yaraş s, Altıntaş e, sezgin O, emekdaş G, Gürer Giray B, sungur MA. Determination of hepatitis c virus genotype distribution in Mersin province, Turkey. Mikrobiyol Bul. 2013; 47: 332-338
  9. Armstrong GL, Wasley A, simard eP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis c virus infection in the united states, 1999 through 2002. Ann Intern Med. 2006; 144: 705-714
  10. Karaca c, cakaloğlu Y, Demir K, Ozdil s, Kaymakoğlu s, Badur s, Okten A. risk factors for the transmission of hepatitis c virus infection in the Turkish population. Dig Dis sci. 2006; 51: 365- 369
  11. Alter MJ. epidemiology of hepatitis c viru