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Journals / European Journal of Biology / 2020 / Cilt: 79 - Sayı: 1

The Effects of Ghrelin on Renal Complications in Newborn Diabetic Rats

Ayse KARATUG KACAR
Ozlem SACAN
Neslihan OZICLI
Sehnaz BOLKENT
Refiye YANARDAG
Sema BOLKENT
Pages
1–6
Publication Date
2020-06-17
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: It can be said that the ghrelin given exogenously has a protective effect in some degree on renal complications in newborn diabetic rats.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Ghrelin is an orexigenic hormone mainly released from the stomachs of rats and takes a significant part in the development of newborn rats.
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Key Findings & Data:Lipid peroxidation levels decreased, while superoxide dismutase, catalase activities, and glutathione levels increased in the diabetic group given ghrelin.
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Conclusion & Impact:Conclusion: It can be said that the ghrelin given exogenously has a protective effect in some degree on renal complications in newborn diabetic rats.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Diabetes · ghrelin · kidney

Abstract

Objective: Ghrelin is an orexigenic hormone mainly released from the stomachs of rats and takes a significant part in the development of newborn rats. Ghrelin has been shown to possess antioxidant, anti-apoptotic, and anti-inflammatory properties. In this study, we aimed to examine microscopical and biochemical parameters in the kidney of newborn nontreated diabetic and ghrelin-treated diabetic rats. Materials and Methods: Wistar-type newborn rats were divided into four groups. First group: control rats given physiological saline for four weeks; second group: control animals given ghrelin from the third day to the fourth week; third group: diabetic rats given streptozotocin (STZ) on the second day after birth as a single dose; fourth group: diabetic rats given ghrelin from the third day to the fourth week. Results: There was no microscopic difference between the kidney tissues of non-treated diabetic and ghrelin-treated diabetic rats. Lipid peroxidation levels decreased, while superoxide dismutase, catalase activities, and glutathione levels increased in the diabetic group given ghrelin. Serum urea, uric acid, creatinine levels, myeloperoxidase, and xanthine oxidase activities decreased in diabetic rats treated with ghrelin. Conclusion: It can be said that the ghrelin given exogenously has a protective effect in some degree on renal complications in newborn diabetic rats.

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Cite This Article

KACAR, A. K., SACAN, O., OZICLI, N., BOLKENT, S., YANARDAG, R., BOLKENT, S. (2020). The Effects of Ghrelin on Renal Complications in Newborn Diabetic Rats. European Journal of Biology, Cilt: 79 - Sayı: 1, 1–6. https://ajindex.com/articles/33170

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References (14)

  1. Edlund H. Developmental biology of the pancreas. Diabetes 2001; 50(Suppl 1): S5-S9
  2. Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, et al. Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 2005; 53: 1087-97
  3. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 2006; 103: 2334-9
  4. Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002; 107: 63-9
  5. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 2004; 101: 2924-9
  6. Chanoine JP, Wong AC. Ghrelin gene expression is markedly higher in foetal pancreas compared with foetal stomach: effect of maternal fasting. Endocrinology 2004; 145: 3813-20
  7. O. Ukkola, Ghrelin and metabolic disorders. Curr Protein Pept Sc 2009; 10-1: 2-7
  8. Ostergard T, Hansen TK, Nyholm B, Gravholt CH, Djurhuus CB, Hosoda H, et al. Circulating ghrelin concentrations are reduced in healthy offspring of type 2 diabetic subjects, and are increased in women independent of a family history of type 2 diabetes. Diabetologia 2003; 46-1: 134-6
  9. Poykko SM, Kellokoski E, Horkkoe S, Kauma H, Kesäniemi YA, Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003;52-10: 2546-53
  10. Barazzoni R, Zanetti M, Ferreira C, Vinci P, Pirulli A, Mucci M, et al. Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome. J Clin Endocrinol Metab 2007; 92: 3935-40
  11. McCowen KC, Maykel JA, Bistrian BR, Ling PR. Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J Endocrinol 2002; 175: R7-R11
  12. Saad MF, Bernaba B, Hwu CM, Jinagouda S, Fahmi S, Kogosov E, et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 2002; 87: 3997-4000
  13. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 2001; 86: 5083-6
  14. Broglio F, Go