Journals / Türk Toraks Dergisi / 2012 / Cilt: 13 - Sayı: 4

Akciğer kanserli bir olguda pozitron emisyon tomografide yanlış pozitiflik ve yanlış negatiflik

False positivity and false negativity on positron emission tomography in a patient with lung cancer

Pages
174–177
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Clinicians who deals with management of lung cancer should keep in mind that PET-BT may cause false positive and false negative results, so histopathological confirmation is necessary, and multiple independent primary tumors may accompany to lung cancer, even non-tobacco related ones, but it does not seem to be effective in the prognosis of the patient. (Turk Toraks Derg 2012; 13: 174-7)

📌 3 Key Takeaways

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Objective & Hypothesis:Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung cancer (NSCLC) accounts for about 85% of the cases.
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Key Findings & Data:Since its introduction in 2001, positron emission tomography (PET-CT) has been used in early diagnosis, staging, early and accurate detection of recurrences.
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Conclusion & Impact:Clinicians who deals with management of lung cancer should keep in mind that PET-BT may cause false positive and false negative results, so histopathological confirmation is necessary, and multiple independent primary tumors may accompany to lung cancer, even non-tobacco related ones, but it does not seem to be effective in the prognosis of the patient. (Turk Toraks Derg 2012; 13: 174-7)
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Domain Parameters

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung cancer (NSCLC) accounts for about 85% of the cases. Since its introduction in 2001, positron emission tomography (PET-CT) has been used in early diagnosis, staging, early and accurate detection of recurrences. In this report, we wish to present a case of lung cancer who was upstaged after thoracotomy and lymph node dissection despite a first evaluation with PET-BT and also, during follow up, the patient was misdiagnosed as a recurrence due to false positive uptake on PET-BT. Interestingly, the patient also had a synchronous testicular tumor which was not smoking-related. In this case, the false positive and false negative results of PET-BT was seen in the same patient. Additionally, the patient had a seminoma accompanying the lung cancer, which was not reported previously. Clinicians who deals with management of lung cancer should keep in mind that PET-BT may cause false positive and false negative results, so histopathological confirmation is necessary, and multiple independent primary tumors may accompany to lung cancer, even non-tobacco related ones, but it does not seem to be effective in the prognosis of the patient. (Turk Toraks Derg 2012; 13: 174-7)

Özet

Akciğer kanseri dünyada kansere bağlı ölümlerde başı çekmektedir, küçük hücre dışı akciğer kanseri (KHDAK) olguların %85’ini oluşturur. Pozitron emisyon tomografi (PET-BT) 2001 yılında kullanıma girişinden itibaren erken tanı, evreleme ve rekürenslerin erken ve doğru tesbitinde kullanılmaktadır. Bu yayında PET-BT ile ilk değerlendirmeye rağmen, torakotomi ve lenf nodu diseksiyonu ile evresi yükselen ve aynı zamanda PETBT’de yanlış pozitif tutulum nedeniyle rekürens olarak değerlendirilen bir olguyu sunmak istedik. İlginç bir şekilde hastanın sigarayla ilintili olmayan bir testis tümörü de vardı. Bu olguda PET-BT’de yanlış pozitif ve yanlış negatiflik aynı zamanda görüldü. Ek olarak, hastanın daha önce tesbit edilmemiş seminomu vardı. Akciğer kanseri takip ve tedavisi ile ilgilenen klinisyenler PET-BT’de yanlış pozitif ve yanlış negatif sonuçlar olabileceğini, bu nedenle histopatolojik doğrulamanın gerekli olduğunu akıllarında bulundurmalıdır. Ayrıca, akciğer kanserine sigarayla ilişkili olmasa bile multipl bağımsız primer tümör eşlik edebilir, ancak bu durum prognoza etki etmemektedir. (Turk Toraks Derg 2012; 13: 174-7)

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Cite This Article

AKPINAR, E. E., HALİLOĞLU, A. H., ÖZTÜRK, E., GÜLHAN, M. (2012). Akciğer kanserli bir olguda pozitron emisyon tomografide yanlış pozitiflik ve yanlış negatiflik. Türk Toraks Dergisi, Cilt: 13 - Sayı: 4, 174–177. https://ajindex.com/articles/329493

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References (15)

  1. Molina JR, Yang P, Cassivi SD, et al. Non-small cell lung cancer: Epidemiology, risk factors, treatment and survivorship. Mayo Clinic Proceedings 2008;83:584-94
  2. Aguilo R, Macia F, Porta M, et al. Multiple independent primary cancers do not adversely affect survival of the lung cancer patient. Eur J Cardiothorac Surg 2008;34: 1075-80
  3. Kanzaki R, Higashiyama M, Maeda J, et al. Clinical value of F18-fluorodeoxyglucose positron emission tomographycomputed tomography in patients with non-small cell lung cancer after potentially curative surgery: experience with 241 patients. Interact Cardio Vasc Thorac Surg 2010;10:1009-14
  4. Fischer BM, Mortensen J. The future in diagnosis and staging of lung cancer: Positron emission tomography. Respiration 2006;73:267-76
  5. Atasoy Ç, Sönmez D. Imaging in lung cancer. Turkiye Klinikleri J Med Oncol-Special Topics 2008;1:34-46
  6. Şen E, Gönüllü U. Diagnosis and staging in lung cancer. Turkiye Klinikleri J Med Oncol-Special Topics 2008;1:47-57
  7. Stroobants S, Verschakelen J, Vansteenkiste J. Value of FDG-Pet in the management of non-small cell lung cancer. Eur J Radiol 2003;45:49-59
  8. Ho Shon I, O’Doherty MJ, Maisey MN. Positron emission tomography in lung cancer. Semin Nucl Med 2002;32: 240-70
  9. Patz EF Jr, Lowe VJ, Hoffman JM, et al. Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose. Radiology 1994;91:379-82
  10. Detection of primary and recurrent lung cancer by means of F-18 fluorodeoxyglucose positron emission tomography (FDG PET). J Thorac Cardiovasc Surg 1995;110:130-9
  11. Rankin SC. Staging of non-small cell lung cancer (NSCLC): Cancer imaging 2006;6:1-3
  12. Robinson LA, Ruckdeschel JC, Wagner H Jr, et al. Treatment of non-small cell lung cancer-stage IIIA: ACCP evidencebased clinical practice guidelines (2nd edition). Chest 2007;132(3 Suppl):243-65
  13. Miyazaki K, Satoh H, Kagohashi K, et al. Lung cancer patients with previous or simultaneous urologic cancers. Med Oncol 2008;25:443-6
  14. Kaya AO, Yıldız R, Öztürk B, et al. Synchronous Squamous Cell Lung Carcinoma and Rectum Adenocarcinoma: Case Report. International Journal of Hematology and Oncology 2008;18:42-4
  15. Ro JY, Sahin AA, Ayala AG, et al. Lung carcinoma with metastasis to testicular seminoma. Cancer 1990;66:347-53.