Journals / Türk Toraks Dergisi / 2013 / Cilt: 14 - Sayı: 4

Hastaneye Yatış Gerektiren KOAH Alevlenmelerinde Mortalite İlişkili Risk Faktörleri

Risk Factors Associated with Mortality of COPD Patients Hospitalised for Exacerbation

Pages
134–140
DOI
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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Prospective studies are required to test the predictive value of changes in PaCO2 for the survival in patients hospitalised for exacerbation of COPD.

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Objective & Hypothesis:OBJECTIVE: To investigate factors associated with mortality and assess the changes in arterial blood gas (ABG) in patients hospitalised for exacerbation of chronic obstructive pulmonary disease (COPD).
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Key Findings & Data:MATERIAL AND METHODS: This was a retrospective analysis of 49 patients (38 men and 11 women) hospitalised in a tertiary care facility for exacerbation of COPD between January 2004 and December 2005.
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Conclusion & Impact:CONCLUSION: Prospective studies are required to test the predictive value of changes in PaCO2 for the survival in patients hospitalised for exacerbation of COPD.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: To investigate factors associated with mortality and assess the changes in arterial blood gas (ABG) in patients hospitalised for exacerbation of chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: This was a retrospective analysis of 49 patients (38 men and 11 women) hospitalised in a tertiary care facility for exacerbation of COPD between January 2004 and December 2005. Data on exposures, ABG, blood chemistry, severity of COPD and treatments were collected from patient charts. Survival status was determined by hospital records and telephone contact with the patients or family members. RESULTS : The average age of patients in the study was 71.1±10.9 years (mean±SD), and the majority were in stage IV (25 cases, 51%) or stage III (15 cases, 30.6%). Comorbidity was reported in 42 cases (85.7%). The median duration of hospital stay was 14.8 days (range: 4-70) days. Ten patients (20.4%) received mechanical ventilation (MV) support. Six male and three female patients died (18.4%); 2 in the hospital (4.1%) and 7 during the 2 year followup (14.9%). Mortality was associated with older age (79.7±12.0 vs. 69.2±9.4 years) and MV support (4/9 deceased vs. 6/40 alive). The change in PaCO2 between the first measurement on admission and during hospitalisation was associated with mortality after discharge (median and range, mmHg, alive: 3 (-29-55.8) and -6 (-10.2-0.1). CONCLUSION: Prospective studies are required to test the predictive value of changes in PaCO2 for the survival in patients hospitalised for exacerbation of COPD.

Özet

AMAÇ: Kronik Obstrüktif Akciğer Hastalığı (KOAH) alevlenmesi ile yatan hastalarda mortalite ile ilişkili etkenleri ve arteriyel kan gazı (AKG) değişikliklerini incelemek. GEREÇ VE YÖNTEMLER: Haziran 2004 ile Aralık 2005 arasında üçüncü basamak bir hastaneye KOAH alevlenmesi için yatırılan 49 (38 erkek, 11 kadın) hastanın retrospektif analizi. Maruziyetler, AKG, kan biyokimyası, KOAH şiddeti ve tedavi bilgileri hasta dosyalarından toplandı. Sağkalım durumu hastane kayıtları ve hasta veya yakınları telefonla aranarak belirlendi. BULGULAR: Ortalama yaş 71,1 yıldı (SS: 10,9). hastaların çoğu evre IV (25 hasta, %51) ve evre III (15 hasta, %30,6) idi. Komorbidite 42 hastada (%85,7) bildirildi. Hastanede kalış süresi ortancası 14,8 gündü (aralık 4-70). On hasta (%20,4) mekanik ventilasyon (MV) desteği aldı. Altı erkek ve 3 kadın hasta (%18,4), 2’si hastanede (%4,1) ve 7’si (%14,9) 2 yıllık izlemde öldü. İleri yaş (yıl olarak ortalama /SS sırasıyla 79,7/12,0 ve 69,2/9,4) ve MV desteği (sırasıyla 6/40, %15 ve 4/9, %44) mortalite ile ilişkili bulundu. Hastane başvurusundaki PACO2 ile sonrasındaki ilk ölçüm arasındaki fark taburculuk sonrası mortalite ile ilişkili bulundu (ortanca ve aralık, mmHg, sağ: 3 (-29-55,8) ve ölen-6 (-10,2-0,1). SONUÇ: KOAH alevlenme ile yatan hastalarda PaCO2 değişikliğinin sağkalımdaki prediktif değerini sınamak için prospektif çalışmalara gereksinim vardır.

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Cite This Article

NİKSARLIOĞLU, E. Y., ARSAVA, B. E., DEMİR, A. U., İSKİT, A. T., ÇÖPLÜ, L. (2013). Hastaneye Yatış Gerektiren KOAH Alevlenmelerinde Mortalite İlişkili Risk Faktörleri. Türk Toraks Dergisi, Cilt: 14 - Sayı: 4, 134–140. https://ajindex.com/articles/329481

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