Journals / Türk Üroloji Dergisi/Turkish Journal of Urology / 2010 / Cilt: 36 - Sayı: 2

Fertil ve infertil asemptomatik erkeklerin semen örneklerinde human papillomavirüsü ve Chlamydia trachomatis: prevalans ve semen parametreleri ile IL-18 arasındaki ilişki

Human papillomavirus and Chlamydia trachomatis in semen samples of asymptomatic fertile and infertile men: Prevalence and relation between semen parameters and IL-18 levels

Pages
143–148
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings might provide a basic data for preventive measures and policy development for sexually transmitted infections in Turkish men.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To determine the prevalence of human papillomavirus (HPV) and Chlamydia trachomatis (C. trachomatis) infections, and the relationship of these infections to semen parameters and proinflammatory cytokine (IL-18) levels in both sexually active and asymptomatic men.
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Key Findings & Data:Materials and methods: One hundred and seventy-five (144 infertile and 31 fertile as control) men were included in this study.
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Conclusion & Impact:These findings might provide a basic data for preventive measures and policy development for sexually transmitted infections in Turkish men.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To determine the prevalence of human papillomavirus (HPV) and Chlamydia trachomatis (C. trachomatis) infections, and the relationship of these infections to semen parameters and proinflammatory cytokine (IL-18) levels in both sexually active and asymptomatic men. Materials and methods: One hundred and seventy-five (144 infertile and 31 fertile as control) men were included in this study. The presence of HPV and C. trachomatis were investigated by polymerase chain reaction (PCR) assay in semen samples. IL-18 levels were measured using ELISA method in seminal plasma. Results: The prevalence rates were 1.1% and 8.6% for HPV and C. trachomatis, respectively. All HPV positive samples subtyped as high-risk HPV. There was no significant difference for both HPV and C. trachomatis rates between fertile and infertile groups (p>0.05). Although the seminal parameters between infertile and fertile groups were different (p<0.001), the differences of mean IL-18 levels were statistically insignificant (p>0.05). Conclusion: The prevelance rates of HPV and C. trachomatis in asymptomatic sexually active men in our region were comparable with the other studies. These findings might provide a basic data for preventive measures and policy development for sexually transmitted infections in Turkish men.

Özet

Amaç: Seksüel olarak aktif ve asemptomatik erkeklerde human papillomavirüs (HPV) ve Chlamydia trachomatis (C. trachomatis) enfeksiyonlarının prevalansının ve bu infeksiyonlar ile semen parametreleri ve seminal proinflamatuvar sitokin (IL-18) düzeyleri arasındaki ilişkinin belirlenmesi. Gereç ve yöntem: Çalışmaya 144 infertil ve kontrol grubu olarak 31 fertil olmak üzere, toplam 175 erkek alındı. Semen örneklerinde HPV ve C. trachomatis varlığı polimeraz zincir reaksiyon (PCR) yöntemiyle araştırıldı. IL-18 düzeyleri ise seminal plazmada ELISA yöntemi ile belirlendi. Bulgular: HPV ve C. trachomatis için prevalans oranları sırasıyla %1.1 ve %8.6 olarak bulundu. Tüm HPV pozitif örnekler yüksek risk grubu olarak tiplendirildi. Fertil ve infertil gruplar arasında, HPV ve C. trachomatis varlığı açısından anlamlı fark bulunmadı (p>0.05). İnfertil ve kontrol grupların seminal parametreleri arasında fark istatistiksel olarak anlamlı iken (p 0.05). Sonuç: Bölgemizdeki asemptomatik seksüel aktif erkeklerde HPV and C. trachomatis prevalans oranları diğer çalışmalarla karşılaştırılabilir düzeydeydi. Bu sonuçlar Türk erkeklerinde cinsel yolla bulaşan hastalıklara yönelik önlemler almak ve koruyucu programlar geliştirmek için temel verileri sağlayacaktır.

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Cite This Article

ÇALIŞKAN, T., KOÇAK, İ., KIRDAR, S., SERTER, M., OKYAY, P., GÜLTEKİN, B. (2010). Fertil ve infertil asemptomatik erkeklerin semen örneklerinde human papillomavirüsü ve Chlamydia trachomatis: prevalans ve semen parametreleri ile IL-18 arasındaki ilişki. Türk Üroloji Dergisi/Turkish Journal of Urology, Cilt: 36 - Sayı: 2, 143–148. https://ajindex.com/articles/328684

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References (3)

  1. Serter D. Türkiye’de ve dünyada cinsel yolla bulaşan enfeksiyonlar ve HIV/AIDS. Türkiye Klinikleri J Med Sci 2006;2:1-5
  2. Dohle GR. Inflammatory-associated obstructions of the male reproductive tract. Andrologia 2003;35:321-4. PMID: 14535864 3. Ault KA. Epidemiology and natural history of human papillomavirus infections in the female genital tract. Infec Dis Obstet Gynecol 2006;4:1-5. PMID: 16967912 PMCID: PMC1581465 4. Samoff E, Koumans EH, Markowitz LE, Stenberg M, Sawyer MK, Swan D, et al. Association of Chlamydia trachomatis with persistence of high-risk types of human papillomavirus in a cohort of female adolescents. Am J Epidemiol 2005;162:668-75. PMID: 16120706 5. Wolff H, Neubert U, Volkenandt M, Zochling N, Schlüpen EM, Bezold G, et al. Detection of Chlamydia trachomatis in semen by antibody-enzyme immunoassay compared with polymerase chain reaction, antigen-enzyme immunoassay, and urethral cell culture. Fertil Steril 1994;62:1250-4. PMID: 7957993 6. Alexander RB, Ponniah S, Hasday J, Hebel JR. Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology 1998;52:744-9. PMID: 9801092 7. Huleihel M, Lunenfeld E, Levy A, Potasnik G, Glezerman M. Distinct expression levels of cytokines and soluble cytokine receptors in seminal plasma of fertile and infertile men. Fertil Steril 1996;66:135-9. PMID: 8752625 8. Matalliotakis I, Cakmak H, Fragouli Y, Kourtis A, Arici A, Huszar G. Increased IL-18 levels in seminal plasma of infertile men with genital tract infection. Am J Repro Immun 2006;55:428-33. PMID: 16674600 9. World Health Organization. (1993). Laboratory manual for the examination of human semen and semen-cervical mucus interaction. 3rd ed. New York: Cambridge University Press; 1993. p.5-23
  3. Harwood CA, Spink PJ, Surentheran T, Leigh I M, Villiers EM, Mcgregor JM, et al. Degenerate and nested PCR: a highly sensitive and specific method for detection of human papillomavirus infection in cutaneous warts. J Clin Microbiol 1999;37:3545-55. PMID: 10523550 PMCID: PMC85688 11. Mahony JB, Loinistra KE, Waner J, McMab G, Hobranzska H, Gregson D, et al. Interlaboratory agreement study of a double set of PCR plasmid primers for detection of Chlamydia trachomatis in a variety of genitourinary specimens. J Clin Microbiol 1994;32:87-91. PMID: 8126209 PMCID: PMC262975 12. Giovannelli L, Campisi G, Lama A, Giambalvo O, Osborn J, Margiotta V, et al. human papillomavirus DNA in oral muc