SavedAdd your journal

Journals / Türk Üroloji Dergisi/Turkish Journal of Urology / 2002 / Cilt: 28 - Sayı: 2

The distribution of calcitonine gene related peptide (CGRP) and substance P (SP) on rat bladder after acute urinary retention

Akut üriner retansiyondan sonra rat mesanesinde calcitonine gene related peptide (CGRP) ve substance-P (SP) dağılımı

E. YILMAZ
N. ARIKAN
Pages
146–149
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These micturation problems following acute urinary retention have been concluded not to be related to primary afferent system, CGRP and SP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In a study performed to analyze the reasons for the micturation problems observed following acute urinary retention.
📊
Key Findings & Data:Obstruction was induced in 40 rats and their bladders were evaluated at 3th hours, 2, 7 and 21st days.
💡
Conclusion & Impact:These micturation problems following acute urinary retention have been concluded not to be related to primary afferent system, CGRP and SP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Modeller · hayvan · Üriner retansiyon

Abstract

In a study performed to analyze the reasons for the micturation problems observed following acute urinary retention. Obstruction was induced in 40 rats and their bladders were evaluated at 3th hours, 2, 7 and 21st days. Radioimmunoassey (RIA) methods were used to evaluate Calcitonine Gene Related Peptide (CGRP) and Subtance P (SP) distribution in the rat bladder. Upon statistical analysis of the results no change has been observed regarding CGRP and SP concentrations. These micturation problems following acute urinary retention have been concluded not to be related to primary afferent system, CGRP and SP.

Özet

Akut üriner retansiyondan sonra ortaya çıkan erken miksiyon problemlerinin nedenleri bu çalışmada araştırılmıştır. Çalışmada 40 ratta obstrüksiyon oluşturularak, obstrüksiyondan 3 saat sonra, 2 gün, 7 gün ve 21 gün sonra mesaneleri değerlendirilmiştir. Rat mesanesinde, radioimmunoassey (RIA), metodu kullanılarak Calcitonine Gene Related Peptid (CGRP) ve Substans P (SP) dağılımı incelenmiştir. Alınan sonuçların istatistiksel analizleri sonucunda CGRP ve SP konsantrasyonlarında anlamlı değişiklik izlenmemiştir. Akut üriner retansiyondan sonra ortaya çıkan miksiyon problemlerinin primer aferent sistem dolayısıyla CGRP ve SP ile ilişkili olmadığı saptanmıştır.

🔖

Cite This Article

YILMAZ, E., ARIKAN, N. (2002). The distribution of calcitonine gene related peptide (CGRP) and substance P (SP) on rat bladder after acute urinary retention. Türk Üroloji Dergisi/Turkish Journal of Urology, Cilt: 28 - Sayı: 2, 146–149. https://ajindex.com/articles/328552

References (9)

  1. Lasanen LT, Tammela J, Liesi P et al: The ef-fect of acute distension on vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY) and substan ce P (SP) immunoreactive nerves in fe-male rat urinary bladder. Urol Res 20; 259-263, 1992. 2- ang WM et al: Peptide-Gu J, Blank MA, HuContaining Nerves in Urinary Bladder. Urology 24(4); 353-357, 1984. 3- s HE et al: Loss of Chapple CR, Milner P, MosNeuropeptides in the obstructed Human Bladder. Br J Urol 70; 373-381, 1992
  2. Stief CG, Benard F, Bosch RJLH et al: A pos-sible role for Calcitonine- Gene related Peptide in the regulation of the smooth muscle tone of the bladder and penis. J Urol 143; 392-397, 1990. 5-Dahlstrand C, Dahlström A, Ahlman H et al: Effect of Substance P on Detrusor muscle in rats with diabetic cystopathy. Br J Urol 70; 390-394, 1992
  3. Dixon JS, Jen PYP and Gosling JA: A double-label immunohistochemical study of intramural ganglia from the human male urinary bladder neck. J Anat 190; 125-134, 1997
  4. Erol K, Ulak G, Dönmez T et al: Effects of Vasoactive Intestinal Polypeptide on isolated rat urinary bladder smooth muscle. Urol Int 49; 151-153, 1992. 8- c- Gu J, Restorick JM, Blank MA et al: Vasoa tive intestinal Polypeptide in the normal and unstable bladder. Br J Urol 55; 645-647, 1983
  5. Kinder RB, Restorick JM and Mundy AR: Vasoactive intestinal Polypeptide in the hyper- reflexic neuropathic bladder. Br J Urol 57; 289-291, 1985
  6. Lindner P, Mattiason A and Persson L: Reversibility of detrusor hypertrophy and hyperplasia after removal of intravesical outflow obstruction in the rat. J Urol 140; 642-646, 1988
  7. Uvelius B, Persson L, Mattiason A: Smooth muscle cell hypertrophy and hyperplasia in the rat detrusor after short-time infravesical outflow obstruction. J Urol 131; 173-176, 1984
  8. Malmgren A, Uvelius B, Andersson KE et al: On the reversibility of functional bladder changes induced by infravesical outflow obstruction in the rat. J Urol 143; 1026-1031, 1990. 13- luchi H, Satoh Y, Ono K: Postnatal develop-ment of ne-uropeptide Y-and calcitonine gene re-lated peptide-immunoreactive nerves in the rat urinary blad-der. Anat Embryol 189; 361-373, 1994
  9. Su HC, Wharton J, Polak JM et al: Calcitonine Gene-Related peptide immunoreactivity in affe-rent neurons supplying the urinary tract: Combi-ned retrograde tracting and immunohistochemist-ry. Neuroscience 18(3); 727-747, 1986.