SavedAdd your journal

Journals / Türk Üroloji Dergisi/Turkish Journal of Urology / 2004 / Cilt: 30 - Sayı: 1

The diagnostic efficacy of digital rectal examination (DRE), prostate specific antigen (PSA), transrectal ultrasound of prostate, prostate specific antigen density (PSAD), age related PSA and free/total PSA in the prostate cancer

Prostat kanseri tanısında parmakla rektal inceleme, prostat spesifik antijen(PSA), transrektal ultrasonografi, PSA dansitesi, yaşa göre PSA, serbest/total PSA oranının doğruluğu

Fatih KURTULUŞ
Adem FAZLIOĞLU
Metin EVİRGEN
Osman CEYLAN
Ertan SAKALLI
Mete ÇEK
Pages
40–44
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The overall accuracy of abnormal TRUS fındings, PSAD 0,15 ng/ml/cc, age related PSA and F/T PSA (0,20 cut-off) were determined.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: We investigate the diagnostic efficacy of digital rectal examination, prostate spccifıc antigen, transrectal ultrasound of prostate, prostate specific antigen density, age related PSA and free/total PSA in the prostate cancer.
📊
Key Findings & Data:Materials and Methods: Between 1998 and 2002, we performed TRUS guided prostate biopsies to 233 patients (age 43-80, median 68) with suspicious digital rectal examination and/or PSA>4 ng/ml.
💡
Conclusion & Impact:The overall accuracy of abnormal TRUS fındings, PSAD 0,15 ng/ml/cc, age related PSA and F/T PSA (0,20 cut-off) were determined.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Ultrasonografi · Biyopsi · Prostat neoplazmları

Abstract

Introduction: We investigate the diagnostic efficacy of digital rectal examination, prostate spccifıc antigen, transrectal ultrasound of prostate, prostate specific antigen density, age related PSA and free/total PSA in the prostate cancer. Materials and Methods: Between 1998 and 2002, we performed TRUS guided prostate biopsies to 233 patients (age 43-80, median 68) with suspicious digital rectal examination and/or PSA>4 ng/ml. We detected prostate cancer in 56 patients. The overall accuracy of abnormal TRUS fındings, PSAD 0,15 ng/ml/cc, age related PSA and F/T PSA (0,20 cut-off) were determined. Results: Cancer detection rate were; Only DRE: 0%, only PSA: 7.89%, DRE and PSA: 52%, DRE and PSA>10: 72%, PSA and TRUS: 62.5%, DRE and PSA and TRUS: 76%, Normal DRE and PSA: 4-10, PSAD: 0.15 cut-off: 14%. in age related PSA 70-79,11 biopsies avoided and 2 cancers missed in 81 patients. When the f/t PSA 0.20 cut-off point taken into consideration, 85% sensitivity was detected. Conclusion: Highest accuracy rate was provided with DRE -PSA>10 and DRE-PSA-TRUS combination. PSAD, age related PSA and f/t PSA rate did not provide more Information in prostate cancer detection.

Özet

Prostat kanseri tanısında parmakla rektal inceleme (PRİ), prostat spesifik antijen (PSA), transrektal ultrasonografi (TRUS), PSA dansitesi (PSAD), yaşa göre PSA, serbest/total PSA (s/t PSA) oranının doğruluğunu araştırdık. 1998-2002 tarihleri arasında kliniğimize başvuran, şüpheli rektal inceleme ve/veya PSA>4 ng/ml bulguları bulunan, yaşları 42 ila 80 arasında değişen (ortalama 68) 233 hastaya transrektal ultrason eşliğinde prostat biyopsisi yapıldı. 56 hastada kanser saptandı. TRUS'ta anormal bulgu, PSAD> 0.15ng/ml/cc, (Oesterling ve arkadaşlarının referansları) yaşa-göre PSA aralığı, S/T PSA oranı 10 ve PRİ, PSA, TRUS üçlüsü en yüksek doğruluk oranı saptarken, PSAD yaşa göre PSA, s/t PSA oranı prostat kanseri saptamada ek bir üstünlük sağlamamıştır.

🔖

Cite This Article

KURTULUŞ, F., FAZLIOĞLU, A., EVİRGEN, M., CEYLAN, O., SAKALLI, E., ÇEK, M. (2004). The diagnostic efficacy of digital rectal examination (DRE), prostate specific antigen (PSA), transrectal ultrasound of prostate, prostate specific antigen density (PSAD), age related PSA and free/total PSA in the prostate cancer. Türk Üroloji Dergisi/Turkish Journal of Urology, Cilt: 30 - Sayı: 1, 40–44. https://ajindex.com/articles/328474

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Mettlin C, Murphy G: Why is the prostate cancer death rate declining in the United states? Cancer 82: 249-251, 1998
  2. Roger S, Kirby-Timoty J, Christmas-Michael K, Brawer Foreword by Peter Scardino-Mosby International Limited: Prostate cancer, second edition, chapter 7 screening for prostate cancer, p 80, 77-90, 2001 3- Catalona W, Smith D, Ratcliff T, et al: Measurement of prostate specific antigen in serum as a screening test for prostate cancer. N Engl J Med 324: 1156-1161, 1991
  3. Mettlin C, Lee F, Drago J, et al: The American Cancer Society National Prostate cancer Detection Project: Finding on the detection of early prostate cancer in 2425 men. Cancer 67: 2949- 2958, 1991
  4. Brawer MK, Aramburu EAG, Chen GL, Preston SD, Ellis WJ: The inability of PSA index to enhance the predictive value of PSA in the diagnosis of prostatic carcinoma. J Urol 150: 369-373, 1993
  5. Catalona WJ, Richie JP, Ahmann FR, et al: Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: Result of a multicenter clinical trial of 6,600 men. J Urol 151: 1283-1290, 1994
  6. Cooner W, Mosley R, Rutherford CJ et al: Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate specific antigen. J Urol 143: 1146-1152, 1990
  7. Lee F, Littrup PJ, Torp-Pederson ST, et al: Prostate Cancer: Comparison of transrectal US and DRE or screening. Radiology 168: 389-394, 1988
  8. Benson MC, Whang IS, Olsson CA, McMahon DJ, Cooner WH: The Use of PSA density to enhance the predictive value of intermediate levels of serum PSA. J Urol 147: 817-821, 1992
  9. Seaman E, Whang M, Olsson CA, Katz A, Cooner WH, Benson MC: PSA density (PSAD): Role in patient evaluation and management. Urol Clin North Am 20: 653, 1993
  10. Ohori M, Dunn JK, Scardino PT: In prostatic specific antigen density more useful than PSA levels in the diagnosis of prostate cancer. Urology 46: 666-671, 1995
  11. Bazinet M, Meshref AW, Trudel C et al: Prospective evaluation of prostate specific antigen density and systematic biopsies for early detection of prostatic carcinoma. Urology 43: 44, 1994
  12. Cookson MS, Floyd MK, Ball TP et al: The lack of predictive value of prostate specific antigen density in the detection of prostate cancer in patients with normal rectal examinations and intermediate prostate specific antigen levels. J Urol 154: 1070, 1995
  13. Oesterling JE, Cooner WH, Jacobsen SJ, Guess JA,