SavedAdd your journal

Journals / Türk Üroloji Dergisi/Turkish Journal of Urology / 2007 / Cilt: 33 - Sayı: 1

The treatment with alpha blockers and their effects on sexual function in BPH

BPH’de alfa bloker tedavisi ve cinsel işlevlere etkileri

Murat TEZER
Önder CANGÜVEN
Firdovsi MEMDOV
Ateş KADIOĞLU
Pages
24–35
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The negative effects on ejaculation are pronounced on pharmacologic selective alpha blocker.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Alpha blockers are frequently used as medical therapy for LUTS (Lower Urinary Tract Symptoms).
📊
Key Findings & Data:According to the studies alpha blockers have favorable effects on erectile function but they also decrease the ejaculatory potential.
💡
Conclusion & Impact:The negative effects on ejaculation are pronounced on pharmacologic selective alpha blocker.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Prostat hiperplazisi · Adrenerjik alfa-antagonistleri · İdrar yolu

Abstract

Introduction: Alpha blockers are frequently used as medical therapy for LUTS (Lower Urinary Tract Symptoms). Although the selectivity and pharmacokinetics of alpha blockers are being developed, the clinical effects are found to be similar. The differences of alpha blockers are due to their side effects; alfuzosin ER (XL), doxazosin GITS (XL) and tamsulosin are preferred to other alpha blockers as they have lesser cardiovascular side effects. Recently, in patients with BPH the sexual function and sexual preservation has gain importance and the side effects of alpha blockers has been studied. According to the studies alpha blockers have favorable effects on erectile function but they also decrease the ejaculatory potential. The negative effects on ejaculation are pronounced on pharmacologic selective alpha blocker.

Özet

Alfa (α) blokerler, BPH (Benin Prostat Hiperplazisi)’ye bağlı AÜSB (Alt Üriner Sistem Belirtileri)’nin medikal tedavisinde sıklıkla başvurulan ilaçlardır. Biyoteknolojik ve biyomoleküler çalışmalar ile α blokerlerin prostat selektivitesi ve farmakokinetiği geliştirilmekte ancak klinik etkinlikleri benzer bulunmaktadır. Alfa blokerler arasındaki farklar yan etki potansiyellerinden kaynaklanmakta; alfuzosin ER (XL), doksazosin GITS (XL) ve tamsulosin, kardiyovasküler yan etkilerinin daha az olması ile diğer α blokerlerden ayrılmaktadır. BPH popülasyonunda cinsel işlevlerin sorgulanması ve korunması son yıllarda güncellik kazanmış, kullanılan ilaçların cinsel işlevlere etkileri araştırmalara konu olmuştur. Yapılan çalışmalara göre; α blokerler, erektil işlevler üzerine olumlu etki yapmakta ancak ejakülasyonu azaltıcı potansiyelleri bulunmaktadır. Ejakülasyona olan olumsuz yan etkiler özellikle farmakolojik selektif α bloker ile dikkati çekmektedir.

🔖

Cite This Article

TEZER, M., CANGÜVEN, Ö., MEMDOV, F., KADIOĞLU, A. (2007). The treatment with alpha blockers and their effects on sexual function in BPH. Türk Üroloji Dergisi/Turkish Journal of Urology, Cilt: 33 - Sayı: 1, 24–35. https://ajindex.com/articles/328320

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Braun M, Wassmer G, Klotz T, et al: Epidemiology of erectile dysfunction: Results of the Cologne Male Survey. Int J Impotence Res. 12: 305-11, 2000
  2. Akkus E, Kadioglu A, Esen A, et al: Prevalence and correlates of erectile dysfunction in Turkey: a populationbased study. Eur Urol. 41: 298-304, 2002
  3. Rosen R, Altwein J, Boyle P, et al: Lower urinary tract symptoms and male sexual dysfunction: The Multinational Survey of the Aging Male (MSAM-7). Eur Urol. 44: 637-49, 2003
  4. Azadzoi KM, Babayan RK, Kozlowski R, Siroky MB: Chronic ischemia increases prostatic smooth muscle contraction in the rabbit. J Urol. 170: 659-63, 2003
  5. Azadzoi KM, Schulman RN, Aviram M, Siroky MB: Oxidative stress in arteriogenic erectile dysfunction prophylactic role of antioxidants. J Urol. 174: 386-93, 2005
  6. Marinese D, Patel R, Walden PD: Mechanistic investigation of the adrenergic induction of ventral prostate hyperplasia in mice. Prostate. 54: 230-7, 2003
  7. Bloch W, Klotz T, Loch C, et al: Distribution of nitric oxide synthase implies a regulation of circulation, smooth muscle tone, and secretory function in the human prostate by nitric oxide. Prostate. 33: 1-8, 1997
  8. Chang S, Hypolite JA, Zderic SA: Enchanced force generation by corpus cavernosum smooth muscle in rabbits with partial bladder outlet obstruction. J Urol. 167: 2636- 44, 2002
  9. Kozlowski R, Kershen RT, Siroky MB, et al: Chronic ischemia alters prostate structure and reactivity in rabbits. J Urol. 165: 1019-26, 2001
  10. McVary KT, Rademaker A, Lloyd GL, Gann P: Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol. 174: 1327-433, 2005
  11. Rees RW, Foxwell NA, Ralph DJ, et al: Y-27632, A Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol. 170: 2517-22, 2003
  12. Andersson KE: Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol. 170: 6-14, 2003
  13. Podlasek C, Zelner DJ, McKenna KE: Morphological changes and altered NOS isoform distribution in the BB/ WOR diabetic rat prostate. J Urol. 169 (Suppl.): 285, A1108, 2003
  14. Felsen D, Dardashti K, Ostad M et al: Inducible nitrite oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstruction. J Urol. 169: 1569-72, 2003
  15. Ückert S, Küthe A, Jonas U, Stief CG: Characterization and functional relevance of cyclic nucleotide phosphodiest