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Journals / Türk Üroloji Dergisi/Turkish Journal of Urology / 2010 / Cilt: 36 - Sayı: 1

The relationship of the lymph node positivity to the durations between the initial and last TUR-T and radical cystectomy, and the number of TUR-T in invasive bladder tumors

İnvazif mesane tümörlerinde ilk ve son TUR-T ile radikal sistektomi arasında geçen süreler ve TUR-T sayısının lenf nodu pozitifliği ile ilişkisi

Özgür UĞURLU
Öztuğ ADSAN
Ömer Gökhan DOLUOĞLU
Tevfik Murat KOŞAN
Alp Özgür AKDEMİR
Mesut ÇETİNKAYA
Pages
13–17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Recurrences can be treated with TUR-T till progression to invasive disease in those with superficial bladder tumors.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of our study was to investigate the relation of lymph node positivity to the durations elapsed between the initial and last transurethral resection bladder tumor (TUR-T) and radical cystectomy and the number of TUR-T in invasive bladder tumors.
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Key Findings & Data:Materials and methods: Data of 126 patients who had radical cystectomy for invasive bladder tumors (Stage ≥pT2) in our clinic between 1994 and 2005 were evaluated retrospectively.
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Conclusion & Impact:Recurrences can be treated with TUR-T till progression to invasive disease in those with superficial bladder tumors.
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of our study was to investigate the relation of lymph node positivity to the durations elapsed between the initial and last transurethral resection bladder tumor (TUR-T) and radical cystectomy and the number of TUR-T in invasive bladder tumors. Materials and methods: Data of 126 patients who had radical cystectomy for invasive bladder tumors (Stage ≥pT2) in our clinic between 1994 and 2005 were evaluated retrospectively. One hundred patients with negative lymph nodes (Group 1) and 26 patients with positive lymph nodes (Group 2) were compared with each other according to stages in terms of the duration between inital TUR-T and radical cystectomy, the total number of TUR-T, and the duration between last TUR-T and radical cystectomy. Results: The mean duration between the initial TUR-T and radical cyctectomy was 5.3 month for Group 1, and 8.0 month for Group 2 (p= 0.103), mean number of TUR-T was 1.5 for Group 1 and 1.72 for Group 2 (p=0.440), and mean duration between the last TUR-T and radical cystectomy was 1.67 month for Group 1 and 2.08 month for Group 2 (p=0.129). When the patients within the groups with the same stages were compared with each other, no statistically significant differences were found. Lymph nodes were positive in 13.3% of the patients in T2 stage, in 18% in T3 stage, and 45% in T4 stage. Lymph node positivity significantly increased with the increasing stage (p=0.012). Conclusion: As a conclusion, the duration between TUR-T that bladder tumor has been diagnosed with and radical cystectomy, and total number of TUR-T do not affect lymph node positivity. Recurrences can be treated with TUR-T till progression to invasive disease in those with superficial bladder tumors.

Özet

Amaç: Çalışmamızın amacı invazif mesane tümörlerinde ilk ve son transüretral tümör rezeksiyonu (TUR-T) ile radikal sistektomi arasında geçen süreler ve TUR-T sayısının lenf nodu pozitifliği ile ilişkisini araştırmak idi. Gereç ve yöntem: Kliniğimizde 1994-2005 yılları arasında invaziv mesane tümörü (Evre ≥pT2) nedeniyle radikal sistektomi uygulanan 126 hastanın verileri retrospektif olarak gözden geçirildi. Lenf nodu negatif 100 hasta (Grup 1) ve lenf nodu pozitif 26 hasta (Grup 2), ilk TUR-T ile radikal sistektomi arasında geçen süre, toplam TUR-T sayısı ve son TUR-T ile radikal sistektomi arasından geçen süre açısından evrelere göre birbirleriyle karşılaştırıldı. Bulgular: İlk TUR-T ile radikal sistektomi arasında geçen ortalama süre Grup 1 için 5.3 ay, grup 2 için 8.0 ay (p=0.103), ortalama TUR-T sayısı Grup 1 için 1.5, Grup 2 için 1.72 (p=0.440), son TUR-T ile radikal sistektomi arasında geçen süre Grup 1 için 1.67 ay, Grup 2 için 2.08 ay (p=0.129) idi. Gruplarda yer alan aynı evredeki hastalar birbirleriyle karşılaştırıldığında istatistiksel olarak anlamlı bir fark saptanmadı. T2 evresindeki hastaların %13.3’ünde, T3 evresindeki hastaların %18’inde, T4 evresindeki hastaların %45’inde lenf nodu pozitifliği vardı. Evre arttıkça lenf nodu pozitifliği istatistiksel olarak anlamlı bir şekilde arttı (p=0.012). Sonuç: Sonuç olarak mesane tümörü tanısının konduğu TUR-T ile radikal sistektomi arasında geçen süre ve TUR-T sayısı lenf nodu pozitifliğini etkilememektedir. Yüzeysel mesane kanserlilerde invazif hastalığa progresyon oluncaya dek rekürrensler TUR-T’ler ile tedavi edilebilir.

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Cite This Article

UĞURLU, Ö., ADSAN, Ö., DOLUOĞLU, Ö. G., KOŞAN, T. M., AKDEMİR, A. Ö., ÇETİNKAYA, M. (2010). The relationship of the lymph node positivity to the durations between the initial and last TUR-T and radical cystectomy, and the number of TUR-T in invasive bladder tumors. Türk Üroloji Dergisi/Turkish Journal of Urology, Cilt: 36 - Sayı: 1, 13–17. https://ajindex.com/articles/328127

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