Journals / Ulusal Cerrahi Dergisi / 2008 / Cilt: 24 - Sayı: 4

C-reactive protein in gastrointestinal system anastomosis

Gastrointestinal sistem anastomozlarında C-reaktif protein

Pages
168–172
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: To achieve the early diagnosis of anastomotic leak, the evaluation of the CRP level at 3. day after operation may be helpful for the physician.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: We aimed to evaluate the accuracy of blood C-reactive protein level for early diagnosis of anastomotic leakage that is ahead of the possible dangerous process after gastrointestinal anastomosis.
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Key Findings & Data:Materials and Methods: Between 1 January 2007 and 31 June 2007, 93 patients with anastomosis were prospectively evaluated.
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Conclusion & Impact:Conclusion: To achieve the early diagnosis of anastomotic leak, the evaluation of the CRP level at 3. day after operation may be helpful for the physician.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Ameliyat sonrası komplikasyonlar · C-reaktif protein · İleriye dönük çalışma

Abstract

Purpose: We aimed to evaluate the accuracy of blood C-reactive protein level for early diagnosis of anastomotic leakage that is ahead of the possible dangerous process after gastrointestinal anastomosis. Materials and Methods: Between 1 January 2007 and 31 June 2007, 93 patients with anastomosis were prospectively evaluated. Postoperative clinical course, hemogram, biochemical examination and blood CRP levels were evaluated on 1.,3., and 5. days postoperatively. Anastomotic leakage was defined clinically. Patients without any clinical anastomotic problem during the follow-up formed group 1 whilst patients with anastomotic problems constituted group 2. Results: There were 43 female, 50 male patients. Anastomotic leakage was present in 9 patients (%9.7). Six of them required additional surgical intervention and 3 of them were treated conservatively. Between groups, there were not significantly difference with regards to demographical data, comorbidities, operative causes, postoperative course, biochemical examination and complications except anastomotic leak. CRP levels were similar at postoperative 1.day, but at 3. and 5. days, there were highly significant differences between groups (p<0.001). White blood cell count was not statistically different at 1. and 3. days after operation in patients with anastomotic leakage., but at 5. day, it was significantly higher (p<0.01). Conclusion: To achieve the early diagnosis of anastomotic leak, the evaluation of the CRP level at 3. day after operation may be helpful for the physician.

Özet

Amaç: Gastrointestinal anastomozlardan sonra olası tehlikeli gelişmelerinbaşında gelen anastomoz kaçaklarının erken tanınmasında kan C-reaktif protein (CRP) düzeyinin kullanılabilirliğini araştırma amaçlanmıştır. Yöntem: 1 Ocak 2007 ile 31 Haziran 2007 tarihi arasında anastomoz yapılan 93 hasta prospektif olarak değerlendirildi. Ameliyat sonrası klinik seyir ve 1., 3., ve 5. günlerdeki CRP, tam kan ve biokimyaları incelendi. Anastomoz kaçağı tanısında klinik belirti esas alındı. Klinik takipleri sırasında anastomoz kaçağı bulgusu olmayan ve taburcu edilen hastalar grup 1'i, anastomoz kaçağı gelişen hastalar ise grup 2'yi oluşturdu. Bulgular: Hastaların 43'ü kadın, 50 tanesi ise erkekti. Hastaların 9'unda anastomoz kaçağı tespit edildi (%9.7) ve bunlardan 3'ü konservatif yöntemlerle tedavi edilirken geri kalan 6 hasta tekrar ameliyat edildi. Hastaların demografik verileri, ek hastalık varlığı, ameliyat nedenleri, ameliyat sonrası seyirleri, biokimya ve anastomoz kaçağı dışında gelişen komplikasyonlar açısından gruplar arasında istatistiki fark saptanmadı. CRP seviyeleri incelendiğinde grup 1 ve grup 2 arasında 1. gün değerleri açısından anlamlı fark izlenmezken, 3. ve 5. gün değerleri arasında ileri derecede anlamlı fark olduğu görüldü (p<0.001). Anastomoz kaçağı olan hastalarda lökosit sayısı istatistiksel olarak 1. ve 3. günlerde anlamlı bir fark göstermezken 5. günde anlamlı olarak yükseldi (p<0.01) . Sonuç: Anastomoz kaçaklarının erken tanınması amacıyla kan CRP seviyesineameliyat sonrası 3.günde bakılması hekime yardımcı olabilir

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Cite This Article

AKYILDIZ, Y. H., ARTIŞ, T., AKCAN, A., KÜÇÜK, C., SÖZÜER, E., MUTLU, F. (2008). C-reactive protein in gastrointestinal system anastomosis. Ulusal Cerrahi Dergisi, Cilt: 24 - Sayı: 4, 168–172. https://ajindex.com/articles/325714

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