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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2008 / Cilt: 14 - Sayı: 1

The therapeutic effect of normobaric oxygen in experimental peritonitis and the efficiency of rectal fever, WBC, CRP and procalcitonin in monitoring response of the therapy

Normobarik oksijenin deneysel peritonitin tedavisinde rektal ateş, lökosit, CRP ve prokalsitoninin etkinliği

Tayfun YÜCEL
Doğan GÖNÜLLÜ
Salih GÜÇLÜ
Mutafa ŞİT
Rıza ADALETİ
Seza TETİKKURT
Ali ÖZCAN
Ferda Nihat KÖKSOY
Pages
14–20
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION It was concluded that using of NO in addition to antibiotherapy could increase the success rate of experimental intraabdominal sepsis therapy and blood procalcitonin and WBC levels could be more beneficial than CRP levels in monitoring of the severity of the sepsis.

📌 3 Key Takeaways

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Objective & Hypothesis:It was investigated the effect of using normobaric oxygen (NO) in addition to antibiotherapy in experimental peritonitis and the changes of rectal fever (RF), WBC, CRP and procalcitonin levels were evaluated.
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Key Findings & Data:Four groups were assigned into “no therapy”, “given NO”, “given antibiotic”, “given antibiotic + NO” groups.
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Conclusion & Impact:CONCLUSION It was concluded that using of NO in addition to antibiotherapy could increase the success rate of experimental intraabdominal sepsis therapy and blood procalcitonin and WBC levels could be more beneficial than CRP levels in monitoring of the severity of the sepsis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hayvanlar · Protein öncüleri · Lökosit sayımı

Abstract

It was investigated the effect of using normobaric oxygen (NO) in addition to antibiotherapy in experimental peritonitis and the changes of rectal fever (RF), WBC, CRP and procalcitonin levels were evaluated. METHODS After the preliminary research of the normal values, rats were infected by E. coli intraperitoneally. Four groups were assigned into “no therapy”, “given NO”, “given antibiotic”, “given antibiotic + NO” groups. RESULTS The decline of RF and WBC levels on 3rd and 5th days was recorded in antibiotic + NO group versus the other groups. It was observed that group 4 was superior to the others. The positivity of periton cultures and the inflammation in the muscle were found to be less in antibiotic + NO group. No correlation was found between pathological and microbiological recovery and blood CRP level in all groups. But a significant decrease in blood procalcitonin level was determined in group 4 compared to the other groups. On day 3, procalcitonin and CRPlevels increased with increasing WBC levels. On day 5, procalcitonin levels also decreased in groups with decreased WBC levels, but no significant correlation was found between CRP and WBC levels. CONCLUSION It was concluded that using of NO in addition to antibiotherapy could increase the success rate of experimental intraabdominal sepsis therapy and blood procalcitonin and WBC levels could be more beneficial than CRP levels in monitoring of the severity of the sepsis.

Özet

Deneysel peritonitte, antibiyotik kullanımına normobarik oksijen (O2) eklenmesinin, tedavideki yeri ve bu tedaviye cevabın izlenmesinde, atefl, lökosit, C-reaktif protein (CRP) ve prokalsitoninin etkinli¤inin arafltırılması amaçland›. GEREÇ VE YÖNTEM Normal de¤erleri saptayan ön çalıflmayı takiben gerçeklefltirilen E. coli peritoniti deneyinde, “tedavisiz”, “normobarik O2 tedavisi”, “antibiyotik tedavisi”, “antibiyotik ve normobarik O2 tedavisi” olmak üzere dört grup oluflturuldu. BULGULAR Üçüncü ve dördüncü gün rektal ateflin ve kan lökosit de¤erinin düflmesi açısından grup 4’ün di¤er gruplara üstünlük sa¤- ladı¤ı gözlendi. Grup 4’de periton kültürü pozitifli¤i anlamlı derecede az bulunurken, patolojik incelemede kas inflamasyonu derecesi en düflük düzeyde bulundu. Kan CRP düzeyi tüm gruplarda anlamlı korelasyonlar gösteremedi. Kan prokalsitonin düzeyinde ise grup 4’de di¤er gruplara göre anlamlı azalma saptand›. Üçüncü gün kan lökosit düzeyi arttıkça prokalsitonin ve CRP düzeyi artt›, beflinci gün ise kan lökosit düzeyi düflen gruplarda prokalsitonin düzeyi de düflerken, CRP de¤eri ile anlamlı ba¤lantı kurulamad›. SONUÇ Deneysel olarak kar›niçi sepsis tedavisinde, normobarik O2 tedavisinin antibiyotik tedavisi ile birlikte kullanılmasının, tedavinin baflarısını artırabilece¤i ve sepsis fliddetinin takibinde, kan lökosit ile prokalsitonin düzeyinin CRP’ye göre daha de- ¤erli olabilece¤i kanısına varıld›.

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Cite This Article

YÜCEL, T., GÖNÜLLÜ, D., GÜÇLÜ, S., ŞİT, M., ADALETİ, R., TETİKKURT, S., ÖZCAN, A., KÖKSOY, F. N. (2008). The therapeutic effect of normobaric oxygen in experimental peritonitis and the efficiency of rectal fever, WBC, CRP and procalcitonin in monitoring response of the therapy. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 14 - Sayı: 1, 14–20. https://ajindex.com/articles/324629

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