Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2006 / Cilt: 12 - Sayı: 2

The effects of rapid and slow infusion of fluid on coagulation factors in hemorrhagic shock: an experimental dogs model

Hemorajik şokta hızlı ve yavaş sıvı infüzyonunun koagülasyon faktörleri üzerine etkisi: Köpekte deneysel çalışma

Pages
95–100
DOI
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CONCLUSION: In conclusion, fluid resuscitation should not be unnecessarily aggressive.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: The diagnosis of hemorrhagic shock in a patient with tachycardia and hypotension is generally straightforward.
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Key Findings & Data:METHODS: The study included 30 mongrel dogs.
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Conclusion & Impact:CONCLUSION: In conclusion, fluid resuscitation should not be unnecessarily aggressive.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Kan pıhtılaşması · Şok · kanama

Abstract

BACKGROUND: The diagnosis of hemorrhagic shock in a patient with tachycardia and hypotension is generally straightforward. The difficulty lies in the selection of optimal approach for the patient. In this study on a canine model of deep hemorrhagic shock induced by bleeding, we used various amounts of fluid infusion to determine the most appropriate amount of fluid resuscitation. METHODS: The study included 30 mongrel dogs. Mongrel dogs were randomized to three equal groups of 10. The control group received no treatment. The rapid infusion group received 60 mL/kg of lactated Ringer's solution in half an hour whereas the third group received 30 mL/kg during the same time period. RESULTS: The lactate decreased in the two treatment groups. The platelet and fibrinogen levels did not vary in the slow infusion group but decreased markedly in the rapid infusion group. CONCLUSION: In conclusion, fluid resuscitation should not be unnecessarily aggressive. The coagulation parameters are diluted in proportion with the amount of fluid given. Blood lactate level can be used as a guiding marker in evaluation of treatment effectiveness of hemorrhagic shock patients.

Özet

AMAÇ: Hemoraji ile birlikte taşikardi ve hipotansiyonu olan hastada hemorajik şok teşhisinin konulmasında bir zorluk yoktur. Esas zorluk hastaya uygun tedavinin verilmesinde ortaya çıkar. Bu çalışmada köpeklerde kanatılarak oluşturulan derin hemorajik şok sonrası ayrı sıvı miktarı ile tedavi edilen gruplardaki koagülasyon parametreleri incelendi. Tedavide verilecek en uygun sıvı miktarının saptanması amaçlandı. GEREÇ-YÖNTEM: Çalışmada 30 adet melez köpek kullanıldı. Köpekler rastgele üç gruba ayrıldı; her grup 10 köpekten oluştu. Kontrol grubuna hiçbir tedavi uygulanmadı. Hızlı infüzyon yapılan gruba 60 cc/kg dozunda yarım saatte Ringer laktat solüsyonu verildi. Yavaş infüzyon yapılan gruba ise 30 cc/kg dozunda yarım saatte Ringer laktat solüsyonu verildi. BULGULAR: Tedavi edilen her iki grupta da laktat değerleri düştü. Trombosit ve fibrinojen yavaş infüzyon yapılan grupta fazla düşmedi; hızlı infüzyon yapılan grupta önemli derecede düştüğü gözlendi. SONUÇ: Şokta en kısa zamanda kanama kontrol altına alınmalı ve sıvı resüstasyonunda saldırgan davranılmamalıdır. Verilen sıvı miktarı ne kadar fazla olursa koagülasyon parametreleri o derecede dilüe olacaktır. Hemorajik şoktaki hastaların tedavi etkinliğinin değerlendirilmesinde kan laktat seviyesi yol gösterici bir tetkik olarak kullanılabilir.

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Cite This Article

İKİZCELİ, İ., SÖZÜER, E. M., AVŞAROĞULLARI, L., CANÖZ, Ö., YILDIRIM, C., KÜÇÜK, C. (2006). The effects of rapid and slow infusion of fluid on coagulation factors in hemorrhagic shock: an experimental dogs model. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 12 - Sayı: 2, 95–100. https://ajindex.com/articles/324460

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References (16)

  1. Shoemaker WC. Diagnosis and treatment of the shock sendromes. In: Ayres SM, Grenvik A, Holbrok PR, Shoemaker WC, editors. Testbook of critical care. Philadelphia: W.B. Saunders; 1996. p. 85-102
  2. Stern SA. Low-volume fluid resuscitation for presumed hemorrhagic shock: helpful or harmful? Curr Opin Crit Care 2001;7:422-30
  3. Anabel Barber, Shires III GT, Shires GT. Shock. In: Schwartz SI, Shires GT, Spencer FC, editors. Principles of surgery. New York: McGraw-Hill; 1999. p. 101-22
  4. Guthrie D. Shock. Advanced trauma life support course for physicians. American Collage of Surgeons. Chicago: W.B. Saunders; 1993. p. 57-88
  5. Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, et al. Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine. Acad Emerg Med 2002;9:969-76
  6. Shah KJ, Chiu WC, Scalea TM, Carlson DE. Detrimental effects of rapid fluid resuscitation on hepatocellular function and survival after hemorrhagic shock. Shock 2002;18:242-7
  7. Luchette FA, Robinson BR, Friend LA, McCarter F, Frame SB, James JH. Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. J Trauma 1999;46:873-80
  8. Kapoor R, Prasad K. Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: effect of SOD and catalase. Circ Shock 1994;43:79-94
  9. Davis JW. The relationship of base deficit to lactate in porcine hemorrhagic shock and resuscitation. J Trauma 1994;36:168-72
  10. Craig RL, Poole GV. Resuscitation in uncontrolled hemorrhage. Am Surg 1994;60:59-62
  11. Healey MA, Davis RE, Liu FC, Loomis WH, Hoyt DB. Lactated ringer's is superior to normal saline in a model of massive hemorrhage and resuscitation. J Trauma 1998;45:894-9
  12. Heckbert SR, Vedder NB, Hoffman W, Winn RK, Hudson LD, Jurkovich HJ, et al. Outcome after hemorrhagic shock in trauma patients. J Trauma 1998;45:545-9
  13. Burris D, Rhee P, Kaufmann C, Pikoulis E, Austin B,Eror A, et al. Controlled resuscitation for uncontrolled hemorrhagic shock. J Trauma 1999;46:216-23
  14. Chendrasekhar A, Prabhakar G, Pillai S, Fagerli JC, Barringer LS, Dulaney J, et al. Utility of a bedside Doppler in tracking left ventricular dysfunction related to hemorrhagic shock. Am Surg 1997;63:747-51
  15. Sayek İ, Çakmakçı M. Şok. In: Sayek İ, editör. Temel cerrahi. Ankara: Güneş Yayınevi; 1996. s. 118-37
  16. Siegel JH, Rivkind AI, D