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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2008 / Cilt: 14 - Sayı: 4

Hemorajik şok oluşturulan köpeklerde beyin hasarı ve serum nitrik oksit seviyelerine pirasetamın etkisi

The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock

SEDA ÖZKAN
İBRAHİM İKİZCELİ
Erdoğan Mütevelli SÖZÜER
Levent AVŞAROĞULLARI
Figen ÖZTÜRK
Sebahattin MUHTAROĞLU
Okhan AKDUR
Can KÜÇÜK
Polat DURUKAN
Pages
277–283
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Piracetam, added to the treatment, may decrease ischemic damage in hemorrhagic shock.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: To demonstrate the effect of piracetam on changes in brain tissue and serum nitric oxide levels in dogs submitted to hemorrhagic shock.
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Key Findings & Data:METHODS: The subjects were randomized into four subgroups each consisting of 10 dogs.
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Conclusion & Impact:CONCLUSION: Piracetam, added to the treatment, may decrease ischemic damage in hemorrhagic shock.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Varyans analizi · Zaman faktörleri · Rastgele seçim

Abstract

BACKGROUND: To demonstrate the effect of piracetam on changes in brain tissue and serum nitric oxide levels in dogs submitted to hemorrhagic shock. METHODS: The subjects were randomized into four subgroups each consisting of 10 dogs. Hemorrhagic shock was induced in Group I for 1 hour and no treatment was given to this group. Blood and saline solutions were administered to Group II following 1 hour hemorrhagic shock. Blood and piracetam were given to Group III following 1 hour shock. No shock was induced and no treatment was applied to Group IV. Blood samples were obtained at the onset of the experiment and at 60, 120 and 180 minutes for nitric oxide analysis. For histopathological examination, brain tissue samples were obtained at the end of the experiment. RESULTS: The observed improvement in blood pressure and pulse rates in Group III was more than in Group II. Nitric oxide levels were increased in Group I; however, no correlation between piracetam and nitric oxide levels was determined. It was seen that recovery in brain damage in Group III was greater than in the control group. CONCLUSION: Piracetam, added to the treatment, may decrease ischemic damage in hemorrhagic shock.

Özet

AMAÇ: Hemorajik şok oluşturulan köpeklerde, pirasetamın şoka bağlı nitrik oksit düzeylerinde değişikliğe ve beyin dokusunda oluşan hipoksiye etkisinin olup olmadığı araştırıldı. GEREÇ-YÖNTEM: Denekler randomize olarak 10’ar köpekten oluşan dört gruba ayrıldı. Grup I, bir saatlik hemorajik şoka uğratıldı ve hemorajik şok sonrası tedavi verilmedi. Grup II, bir saatlik hemorajik şoka uğratıldı ve şok sonrası kan ile birlikte serum fizyolojik verildi. Grup III, bir saat hemorajik şoka uğratıldı ve şok sonrası kan ile birlikte intravenöz pirasetam verildi. Grup IV’e ise şok ve tedavi uygulanmadı. Deneyin başlangıcında, 60., 120. ve 180. dakikalarda nitrik oksit analizi için kan örnekleri alındı. Deneyin sonunda, histopatolojik inceleme için beyin doku örnekleri çıkarıldı. BULGULAR: Kan basıncı ve nabız değerlerindeki düzelmenin Grup III’deki deneklerde Grup II’deki deneklere göre daha iyi olduğu saptandı. Grup I’de nitrik oksit seviyelerinde yükselme olmasına rağmen, pirasetamla nitrik oksit seviyeleri arasında herhangi bir ilişki saptanmadı. Deneyin sonunda, Grup III’de hemorajik şoka bağlı gelişen beyin hasarındaki düzelmenin kontrol grubuna göre daha iyi olduğu saptandı. SONUÇ: Tedaviye eklenen pirasetam hemorajik şokta iskemik hasarı azaltabilir.

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Cite This Article

ÖZKAN, S., İKİZCELİ, İ., SÖZÜER, E. M., AVŞAROĞULLARI, L., ÖZTÜRK, F., MUHTAROĞLU, S., AKDUR, O., KÜÇÜK, C., DURUKAN, P. (2008). Hemorajik şok oluşturulan köpeklerde beyin hasarı ve serum nitrik oksit seviyelerine pirasetamın etkisi. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 14 - Sayı: 4, 277–283. https://ajindex.com/articles/324384

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