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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2015 / Cilt: 21 - Sayı: 6

Saving the zone of stasis in burns with melatonin: an experimental study in rats

Muhammed KAYAPINAR
Nevra SEYHAN
Mustafa Cihad AVUNDUK
Nedim SAVACI
Pages
419–424
DOI
—
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Data were evaluated statistically by Chi-square test and Student-t test.RESULTS: When histopatologic data and the measured values for total necrotic areas and zone of stasis of the experimental group werecompared to control group, the results were statistically significant (p<0.05).CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Studies aimed at recovering the zone of stasis are one of the major issues of experimental burn studies.
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Key Findings & Data:Rats were assigned to two groups (n=10).
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Conclusion & Impact:Data were evaluated statistically by Chi-square test and Student-t test.RESULTS: When histopatologic data and the measured values for total necrotic areas and zone of stasis of the experimental group werecompared to control group, the results were statistically significant (p<0.05).CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Studies aimed at recovering the zone of stasis are one of the major issues of experimental burn studies. Many drugs including antithrombotics, anticoagulants, anti-inflammatories have been investigated experimentally for saving the zone of stasis. In this study, the effect of the systemic melatonin on the zone of stasis was evaluated.METHODS: Twenty Wistar Albino rats were used in the study. Rats were assigned to two groups (n=10). The metal comb 1x2 cm in size was immersed in boiling water and held for 20 seconds on the back of the rats to create burn wounds.No treatment was given to the control group. Melatonin was given at a dose of 10 mg/kg/d by intraperitoneal injection in the treatment group for 7 days. Daily digital photographs of both groups were obtained. Total necrotic burn areas and the zone of stasis were assessed with Auto CAD and Visual Analyzing computer programs. At the end of one week, rats were sacrificed and skin biopsies were taken for histological examination. Edema, congestion, inflammatory infiltration, vascular proliferation and fibrosis were the parameters evaluated. Data were evaluated statistically by Chi-square test and Student-t test.RESULTS: When histopatologic data and the measured values for total necrotic areas and zone of stasis of the experimental group werecompared to control group, the results were statistically significant (p<0.05).CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns

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Cite This Article

KAYAPINAR, M., SEYHAN, N., AVUNDUK, M. C., SAVACI, N. (2015). Saving the zone of stasis in burns with melatonin: an experimental study in rats. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 21 - Sayı: 6, 419–424. https://ajindex.com/articles/323763

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References (14)

  1. Uygur F, Evinc R, Urhan M, Celikoz B, Haholu A. Salvaging the zone of stasis by simvastatin: an experimental study in rats. J Burn Care Res 2009;30:872-9. Jackson Dm. The diagnosis of the depth of burning. [Article in Undeter- mined Language] Br J Surg 1953;40:588-96.
  2. Zor F, Ozturk S, Deveci M, Karacalioglu O, Sengezer M. Saving the zone of stasis: is glutathione effective? Burns 2005;31:972-6.
  3. Nisanci M, Eski M, Sahin I, Ilgan S, Isik S. Saving the zone of stasis in burns with activated protein C: an experimental study in rats. Burns 2010;36:397-402.
  4. Işik S, Sahin U, Ilgan S, Güler M, Günalp B, Selmanpakoğlu N. Saving the zone of stasis in burns with recombinant tissue-type plasminogen ac- tivator (r-tPA): an experimental study in rats. Burns 1998;24:217-23.
  5. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11.
  6. Tan DX Chen LD, Poeggeler B. Melatonin: A potent, endogenous hy- droxyl radical scavenge. Endocr J 1993; 1:57-60.
  7. Regas FC, Ehrlich HP. Elucidating the vascular response to burns with a new rat model. J Trauma 1992;32:557-63.
  8. Wang WZ, Fang XH, Stephenson LL, Baynosa RC, Khiabani KT, Zam- boni WA. Microcirculatory effects of melatonin in rat skeletal muscle after prolonged ischemia. J Pineal Res 2005;39:57-65.
  9. Vaughan GM, Reiter RJ. Pineal dependence of the Syrian hamster's noc- turnal serum melatonin surge. J Pineal Res 1986;3:9-14.
  10. Gitto E, Tan DX, Reiter RJ, Karbownik M, Manchester LC, Cuzzocrea S, et al. Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferox- amine) in rat liver homogenates. J Pharm Pharmacol 2001;53:1393-401.
  11. Reiter RJ, Guerrero JM, Garcia JJ, Acuña-Castroviejo D. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci 1998;854:410-24.
  12. Reiter RJ, Tan DX, Osuna C, Gitto E. Actions of melatonin in the reduc- tion of oxidative stress. A review. J Biomed Sci 2000;7:444-58.
  13. Del Zar MM, Martinuzzo M, Falcón C, Cardinali DP, Carreras LO, Va- cas MI. Inhibition of human platelet aggregation and thromboxane-B2 production by melatonin: evidence for a diurnal variation. J Clin Endo- crinol Metab 1990;70:246-51.
  14. Urata Y, Honma S, Goto S, Todoroki S, Iida T, Cho S, et al. Melato- nin induces gamma-glutamylcysteine synthetase mediated by activa- tor protein-1 in human vascular endothelia