AI Summary & Key Takeaways
AI InsightThe treatment and the prognosis of breast lymphomas were not different from the currently indicated for nodal NHL with the same stage and histological subtype.
📌 3 Key Takeaways
Abstract
Non-Hodgkins lymphoma (NHL) of the breast can be either primary or secondary. Both are rare diseases accounting less than 0.6% of all breast malignancies. In this study we report our experience with five cases of breast lymphoma, 3 of them being primary and 2 of them being secondary breast lymphoma, retrospectively. All patients were female with a median age of 47 years and presented with breast masses (3 in the right breast and 2 in the left). The histologic subtype showed broad spectrum, one patient had peripheral T-cell lymphoma and 4 patients had B-cell lymphomas; 2 were diffuse large B-cell lymphomas, 1 was a diffuse small B-cell lymphoma, and the last patient was a marginal zone lymphoma. Partial mastectomy was performed in 2 patients to carry out diagnosis. Anthracycline-based chemotherapy regimens were employed in 4 patients. Radiotherapy was added to other treatment modalities in 3 cases. At a median follow-up of 5 years, all patients were alive other than one who had been diagnosed with peripheral T-cell lymphoma just after pregnancy and showed resistance to the applied treatment. The treatment and the prognosis of breast lymphomas were not different from the currently indicated for nodal NHL with the same stage and histological subtype.
Özet
Memede saptanan Non-Hodgkin lenfomalar primer ya da sekonder olabilir. Her ikisi de oldukça nadir olup, meme kanserlerinin yaklaşık %0.6sını oluştururlar. Bu çalışmada, kliniğimizde izlenen 3ü primer, 2si sekonder meme lenfoması olan olguları geriye dönük olarak inceleyerek kendi tecrübelerimizi bildirmek istedik. Bütün hastalar kadındı ve ortalama yaş 47 idi. Bütün hastalarda memede kitle şikayeti vardı (3 hastada sağ, 2 hastada sol). Histolojik alt tipleri geniş bir spektruma sahipti; 1 hastada periferal T hücreli lenfoma, 4 hasta B hücreli lenfoma (2 hasta diffüz büyük B-hücreli, 1 hasta diffüz küçük B-hücreli, 1 hasta marjinal zon lenfoma) olarak tanı aldı. iki hastada tanısal amaçlı parsiyel mastektomi yapıldı. 4 Hastada antrasiklin esaslı kemoterapi rejimi uygulandı. Üç hastada tedaviye radyoterapi eklendi. Ortalama 5 yıllık takip sonrası, gebelikten hemen sonra periferal T hücreli lenfoma tanısı alan ve kemoterapiye dirençli olan olgu dışındaki diğer 4 olgu hayattaydı. Meme lenfomalarının tedavi ve prognozları, aynı evre ve histolojik tipteki nodal lenfomalardan farklı değildir.