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Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2008 / Cilt: 18 - Sayı: 3

İntratekal metotreksat ve nörotoksisite: Ağrılı bir deneyim

Intrathecal methotrexate and acute neurotoxicity: A painful experience

Akif ALTINBAŞ
Şafak ÇAVUŞ
Ebru KOCA
Deniz ÇETİNER
Ali SHORBAGI
C. İbrahim HAZNEDAROĞLU
Pages
163–165
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Available treatment options are also discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Intrathecal treatment with methotrexate, an essential chemotherapeutic for both prophylaxis and treatment of central nervous system involvement of leukemia, may be associated with local neurotoxicity and/or systemic toxicity.
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Key Findings & Data:Presented here is a case of a 58 year old patient with acute lymphoblastic leukemia who developed acute neurotoxicity after her 13th dose of intrathecal methotrexate.
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Conclusion & Impact:Available treatment options are also discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nörotoksisite sendromları · Orta yaşlı · Enjeksiyon

Abstract

Intrathecal treatment with methotrexate, an essential chemotherapeutic for both prophylaxis and treatment of central nervous system involvement of leukemia, may be associated with local neurotoxicity and/or systemic toxicity. Signs of acute neurotoxicity include confusion, disorientation, seizures, aphasia, ataxia, dysarthria, paresis and even paralysis. Presented here is a case of a 58 year old patient with acute lymphoblastic leukemia who developed acute neurotoxicity after her 13th dose of intrathecal methotrexate. Available treatment options are also discussed.

Özet

Lösemilerin santral sinir sistemi tutulum açısından hem profilaksisinde hem de tedavisinde yeri olan intratekal metotreksat tedavisi, lokal nörotoksisite ve/veya sistemik toksisiteye neden olabilir. Akut nörotoksisite bulguları, konfüzyon, dezoryantasyon, nöbet, afazi, ataksi, dizartri, parezi ve paralizi şeklinde kendini gösterebilir. Sunduğumuz vaka, 58 yaşında, akut lenfoblastik lösemi tanısı ile almakta olduğu intratekal metotreksatın 13. dozundan sonra akut nörotoksisite gelişti. Bu durumda tercih edilebilecek uygun tedavileri de tartışmaya çalıştık.

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Cite This Article

ALTINBAŞ, A., ÇAVUŞ, Ş., KOCA, E., ÇETİNER, D., SHORBAGI, A., HAZNEDAROĞLU, C. İ. (2008). İntratekal metotreksat ve nörotoksisite: Ağrılı bir deneyim. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 18 - Sayı: 3, 163–165. https://ajindex.com/articles/323234

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