Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2010 / Cilt: 20 - Sayı: 2

Akciğer kanserinde neopterinin tanısal değeri

The diagnostic role of neopterin in lung cancer

Pages
84–88
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion the standardized BAL and serum neopterin levels were inadequate to distinguish the lung cancer from the control group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was to investigate the relationship between bronchoalveolar lavage (BAL) neopterin levels and lung cancer subtypes.
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Key Findings & Data:A total of 43 patients, 36 male and 7 female, who applied to our hospital were included in this cross sectional study.
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Conclusion & Impact:In conclusion the standardized BAL and serum neopterin levels were inadequate to distinguish the lung cancer from the control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study was to investigate the relationship between bronchoalveolar lavage (BAL) neopterin levels and lung cancer subtypes. Serum and BAL fluid samples were collected from lung cancer patients and control cases. BAL and serum neopterin levels were measured spectrofotometrically using the Neopterin ELISA kit. A total of 43 patients, 36 male and 7 female, who applied to our hospital were included in this cross sectional study. Thirty-two of the patients had confirmed primary lung cancer, while the 11 patients who formed the control group had benign lung diseases. The mean age in the lung cancer group was 59.8 ± 7.9, while for the control group it was 47.6 ± 8.2 years. The standardized BAL neopterin levels were 2.63 ± 1.53 nmol/L in NSCLC patients, 2.09 ± 1.02 nmol/L in SCLC patients, 2.36 ± 0.83 nmol/L in control groups. No significant difference was found. For patients with NSCLC, no correlation could be established between serum and BAL neopterin levels and stage of disease. In conclusion the standardized BAL and serum neopterin levels were inadequate to distinguish the lung cancer from the control group.

Özet

Çalışmanın amacı akciğer kanseri alt tipleriyle bronkoalveoler lavaj (BAL) neopterin düzeyleri arasındaki ilişkiyi araştırmaktır. Akciğer kanserli hastalardan ve kontrol vakalardan serum ve BAL sıvı örnekleri toplandı. BAL ve serum neopterin düzeyleri Neopterin ELISA kiti kullanılarak spektrofotometrik olarak ölçüldü. Hastanemize başvuran toplam 43 hasta bu kesitsel çalışmaya dahil edildi. Benign akciğer hastalıklarına sahip 11 hasta kontrol grubunu oluştururken, 32 hastada primer akciğer kanseri teyit edilmişti. Akciğer kanseri grubunda ortalama yaş 59.8±7.9, kontrol grubunda ise 47.6±8.2 yıl idi. Standartlaştırılan BAL neopterin düzeyi küçük hücreli dışı akciğer kanseri (KHDAK) hastalarında 2.63 ± 1.53 nmol/L, küçük hücreli akciğer kanseri (KHAK) hastalarında 2.09 ± 1.02 nmol/L, kontrol grubunda 2.36 ± 0.83 nmol/L idi. Gruplar arasında anlamlı fark saptanmadı. KHDAK’lı hastalar için, serum ve BAL neopterin düzeyleri ve hastalığın evresi arasında ilişki kurulamadı. Sonuçta, standartlaştırılan BAL ve serum neopterin düzeyleri, akciğer kanserini kontrol grubundan ayırmada yetersiz kalmaktadır.

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Cite This Article

ALPAR, S., ERSOY, G. G., KURT, Ö. K., UÇAR, N., AYDIN, A., KURT, E. B. (2010). Akciğer kanserinde neopterinin tanısal değeri. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 20 - Sayı: 2, 84–88. https://ajindex.com/articles/323218

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