Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2011 / Cilt: 21 - Sayı: 2

bronkoskopik biyopsi öncesi ve sonrasında uygulanan bronkoalveoler lavajın periferik akciğer kanseri tanısına katkısı

The contribution of bronchoalveolar lavage performed before and after bronchoscopic biopsies to the diagnosis of peripheral lung cancer

Pages
80–86
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The BAL performed after other biopsy procedures have a significant additive effect on diagnosis.

📌 3 Key Takeaways

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Objective & Hypothesis:The sensitivity of all fiberoptic bronchoscopic techniques in case of a peripheral lung cancer is 69%.
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Key Findings & Data:BAL was performed prior (BAL 1) and after (BAL 2) other biopsies.
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Conclusion & Impact:The BAL performed after other biopsy procedures have a significant additive effect on diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The sensitivity of all fiberoptic bronchoscopic techniques in case of a peripheral lung cancer is 69%. In the study, it was aimed to assess the contribution of broncoalveolar lavage (BAL) performed before and after standard biopsy procedures in the diagnosis of peripheral lung cancer. The patients with peripheral lung lesion in radiology, and normal bronchoscopic findings were included in the study, prospectively. BAL was performed in all patients additionally standard biopsy procedures (forceps biopsy, bronchial brushing, trans bronchial forceps biopsy, trans bronchial needle aspiration). BAL was performed prior (BAL 1) and after (BAL 2) other biopsies. Thirty male with a mean age of 61.9 years were included. In radiology, 26 patients had peripheral-located node or mass and four had an infiltrative pattern of involvement. The cytology / histopathology was adenocarcinoma in 12, non-small cell carcinoma in 9, squamous cell carcinoma in 7 and small cell carcinoma in 2. The cytology of BAL was positive in 6 (20%). The diagnosis was made by cytology of BAL alone in 1, by standard biopsy procedures in 19, and by trans thoracic needle aspiration in 10. The diagnostic yield, with the combined use of BAL and standard biopsies was 66%. The difference of diagnostic yield between BAL 1 (13.3%) and BAL 2 (20%) was significant (p= 0.003). The addition of cytology of bronchoalveolar lavage in peripheral lung cancer may increase the diagnostic yield of bronchoscopy and spare some patients from unnecessary invasive procedures. The BAL performed after other biopsy procedures have a significant additive effect on diagnosis.

Özet

Periferik akciğer kanserinde fiberoptik bronkoskopi tekniğinin duyarlılığı %69’dur. Çalışmada, periferik akciğer kanserinde standart biyopsi yöntemlerinden önce ve sonra uygulanan bronkoalveolar lavaj (BAL)’ın teşhise katkısını değerlendirmek amaçlandı. Radyolojik olarak periferik akciğer lezyonu ve normal bronkoskopik bulguları olan hastalar prospektif olarak çalışmaya alındı. Tüm hastalara standard biyopsi yöntemleri (forseps biyopsi, bronşiyal fırça, trans bronşiyal forseps biyopsi, trans bronşiyal iğne biyopsisi)’ne ek olarak BAL uygulandı. BAL diğer biyopsilerden önce (BAL 1) ve sonra (BAL 2) alındı. Yaş ortalaması 61.9 yıl olan 30 erkek hasta alındı. Radyolojik olarak, 26 hastada periferik yerleşimli nodül veya kitle ve 4 hastada infiltratif görünümde tutulum mevcut idi. Sitoloji / histopatoloji 12 hastada adenokarsinom, 9’unda küçük hücreli dışı karsinom, 7’sinde squamöz hücreli karsinom ve 2’sinde küçük hücreli karsinom ile uyumlu idi. BAL sitolojisi 6 (%20) hastada pozitif idi. Teşhis, bir hastada BAL sitolojisi, 19’unda standart biyopsi prosedürleri ve 10’unda trans torasik iğne aspirasyonu ile konuldu. Standart biyopsiler ve BAL uygulamasının kombine kullanımı ile tanısal katkı %66 oldu. Teşhise katkı açısından BAL 1 (%13.3) ve BAL 2 (%20) arasındaki fark anlamlı bulundu (p= 0.003). Periferik akciğer kanserinde BAL sitolojisinin çalışılması bronkoskopinin tanısal katkısını artırmakta ve bazı hastaları gereksiz invaziv prosedürlerden korumaktadır. BAL'ın diğer biyopsi yöntemlerinden sonra uygulanması, tanısal verimini artırmaktadır.

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Cite This Article

TATAR, D., GÜNEŞ, E., ERBAYCU, A. E., YÜCEL, N., HALİLÇOLAR, H. (2011). bronkoskopik biyopsi öncesi ve sonrasında uygulanan bronkoalveoler lavajın periferik akciğer kanseri tanısına katkısı. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 21 - Sayı: 2, 80–86. https://ajindex.com/articles/323170

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