Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2012 / Cilt: 22 - Sayı: 3

Yumuşak doku ve kemik sarkomlarında 18F-FDG PET/BT klinik deneyimi

Clinical experience of 18F-FDG PET/CT in soft tissue and osseous sarcomas

Pages
163–169
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this retrospective analysis we concluded that 18F-FDG PET/CT is a functional imaging modality which can be used successfully in addition to conventional imaging modalities in soft tissue and osseous sarcomas.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this retrospective analysis was to describe our clinical experience for fluorine-18 (18F) fluorodeoxglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with soft tissue and osseous sarcoma.
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Key Findings & Data:Total of 26 18F-FDG PET/CT scans were evaluated in 17 patients (7 osteosarcoma, 5 Ewing’s sarcoma, 3 uterine sarcoma and 2 rhabdomyosarcoma) in different stages of disease. 18F-FDG PET/CT was applied on postoperative period except for one patient.
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Conclusion & Impact:In this retrospective analysis we concluded that 18F-FDG PET/CT is a functional imaging modality which can be used successfully in addition to conventional imaging modalities in soft tissue and osseous sarcomas.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Yumuşak doku neoplazileri · Pozitron-emisyon tomografi ve bilgisayarlı tomografi · Geriyedönük çalışma

Abstract

The aim of this retrospective analysis was to describe our clinical experience for fluorine-18 (18F) fluorodeoxglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with soft tissue and osseous sarcoma. Total of 26 18F-FDG PET/CT scans were evaluated in 17 patients (7 osteosarcoma, 5 Ewing’s sarcoma, 3 uterine sarcoma and 2 rhabdomyosarcoma) in different stages of disease. 18F-FDG PET/CT was applied on postoperative period except for one patient. The results of 18F-FDG PET/CT, conventional imaging modalities (CT and/or MRI) and clinical follow-up data were reviewed retrospectively. The range of the period between conventional imaging modalities and 18F-FDG PET/CT was 1-6 months. The mean follow-up period was 3.8±0.2 years. The findings of CT and/or MRI and 18F-FDG PET/CT were compared on the patient basis. Concordance was seen in 7 of 17 patients and discordance in 10 of 17 patients. In the concordant group, results were normal in 4 of 7 patients. Local recurrence or distant metastases did not seen in these patients during the follow-up period. In one patient who had undergone 18F-FDG PET/CT for preoperative staging, both of 18F-FDG PET/CT and CT examinations showed the primary lesion on the clavicula. Distant metastases (liver, lung, lymph nodes) were defined with the 18F-FDG PET/CT and conventional imaging modalities in two patients. In the discordant group, 18F-FDG PET/CT scans were normal in 4 patients who had multiple nodules on the both lungs in CT. These patients were followed up in remission. Local recurrence and distant metastases (bone, peritonium, lymph nodes) which could not be detected by conventional imaging modalities were seen in three patients, respectively. In this retrospective analysis we concluded that 18F-FDG PET/CT is a functional imaging modality which can be used successfully in addition to conventional imaging modalities in soft tissue and osseous sarcomas.

Özet

Bu retrospektif analizin amacı yumuşak doku ve kemik sarkomlu hastalarda flor-18 (18F) florodeoksiglukoz (FDG) pozitron emisyon tomografi/bilgisayarlı tomografi (PET/BT) kullanımı ile ilgili deneyimlerimizi ortaya koymaktır. Onyedi olgunun (7 osteosarkom, 5 Ewing sarkomu, 3 uterin sarkom, 2 rabdomyosarkom) hastalığının değişik evrelerinde çekilen toplam 26 18F-FDG PET/BT sonucu değerlendirildi. 18F-FDG PET/BT, 1 hasta dışında tüm hastalara postoperatif dönemde uygulandı. 18F-FDG PET/BT, konvansiyonel görüntüleme yöntemleri (BT ve/veya MR) ve klinik takip sonuçları retrospektif olarak gözden geçirildi. Konvansiyonel görüntüleme yöntemleri ile 18F-FDG PET/BT arasındaki süre aralığı 1-6 aydı. Ortalama takip süresi 3.8±0.2 yıldı. BT ve/veya MR ve 18F-FDG PET/BT bulguları hasta bazında değerlendirildi. 17 hastanın 7’sinde uyumluluk, 10’unda ise uyumsuzluk görüldü. Uyumlu grupta 4 hastanın sonuçları normaldi. Bu hastaların takip sürelerinde lokal rekürrens ya da uzak metastaz görülmedi. 18F-FDG PET/BT’nin preoperatif dönemde uygulandığı bir hastada 18F-FDG PET/BT ve BT klavikuladaki primer lezyonu gösterdi. iki hastada 18F-FDG PET/BT ve konvansiyonel görüntüleme yöntemleri ile uzak metastaz (karaciğer, akciğer, lenf nodu) tanımlandı. Uyumsuz grupta BT’de her iki akciğerde birden fazla nodülleri olan 4 hastada 18F-FDG PET/BT normaldi. Bu hastalar remisyonda takip edildi. 18F-FDG PET/BT ile konvansiyonel görüntüleme yöntemleri ile saptanamayan lokal rekürrens ve uzak metastazlar (kemik, periton, lenf nodu) sırasıyla üçer hastada saptandı. Bu retrospektif analizde 18F-FDG PET/BT’nin yumuşak doku ve kemik sarkomlu hastalarda konvansiyonel görüntüleme yöntemlerine ek olarak başarı ile uygulanabilecek fonksiyonel bir görüntüleme yöntemi olduğu sonucuna vardık.

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Cite This Article

ÖZKAN, E., SOYDAL, Ç., ARAZ, M., KÜÇÜK, N. Ö. (2012). Yumuşak doku ve kemik sarkomlarında 18F-FDG PET/BT klinik deneyimi. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 22 - Sayı: 3, 163–169. https://ajindex.com/articles/323110

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