SavedAdd your journal

Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2006 / Cilt: 16 - Sayı: 2

Efficacy of intravenous anti-D therapy in childhood chronic idiopathic thrombocytopenic purpura

Kronik immün trombositopenik purpuralı çocuklarda intravenöz anti-D tedavisinin etkinliği

Ali BAY
Ahmet F. ÖNER
Murat DOĞAN
Mehmet AÇIKGÖZ
İmdat DİLEK
Pages
63–66
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study we examined eleven patients with chronic immune thrombocytopenic purpura (ITP) who received anti D retrospectively.
📊
Key Findings & Data:Anti D was given 30µg/kg/dose on 0, 1, 7, 14, 21, 28 days by intravenous infusion in one hour.
💡
Conclusion & Impact:In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Çocuk · Enjeksiyon · ven içi

Abstract

In this study we examined eleven patients with chronic immune thrombocytopenic purpura (ITP) who received anti D retrospectively. All of the cases have Rh+ blood group and non-splenectomized. Anti D was given 30µg/kg/dose on 0, 1, 7, 14, 21, 28 days by intravenous infusion in one hour. Three of them (27%) had complete response, three of them (27%) had partial response, three of them (27%) had minor response, and two of them (18%) didn’t response. On following, only one patient who responded initially, had high trombocyte count over 1 year. The other patient’s trombocyte counts were decreased to the initial level within 1-3 months after the treatment. We did not observe any important side effect. In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.

Özet

Bu çalışmada steroid ve intravenöz immunoglobuline dirençli 11 kronik immun trombositopenik purpuralı (ITP) olguda Anti D ile tedavi sonuçları değerlendirildi. Olguların hepsi Rh + kan grubundandı ve hiç birisine splenektomi yapılmamıştı. Anti D 30 µg/kg/gün dozunda 0, 1, 7, 14, 21, 28. günlerde 1 saat içinde İV yavaş infüzyonla verildi. Olguların 3 tanesi (%27) tam cevap, 3 tanesi (%27) parsiyel cevap, 3 tanesi (%27) minor cevap verirken, 2 tanesi (%18) cevapsızdı. Cevap veren olguların sadece 1 tanesinde trombosit sayısı 1 yıldan daha fazla yüksek kaldı. Diğer olguların trombosit sayısı 1-3 ay içinde tedavi öncesi değerlerine düştü. Önemli bir yan etki saptanmadı. Dirençli kronik ITP li çocuklarda anti D tedavisinin de bir seçenek olarak dikkate alınması gerektiği sonucuna varıldı.

🔖

Cite This Article

BAY, A., ÖNER, A. F., DOĞAN, M., AÇIKGÖZ, M., DİLEK, İ. (2006). Efficacy of intravenous anti-D therapy in childhood chronic idiopathic thrombocytopenic purpura. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 16 - Sayı: 2, 63–66. https://ajindex.com/articles/323067

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Lilleyman JS. Management of childhood idiopathic thrombocytopenic purpura. Br J Haemotol 105:871-875, 1999
  2. Eden OB, Lilleyman JS. Guidelines for management of idiopathic thrombocytopenic purpura. The British Paediatric Haemtalogy Group. Arch Dis Child 67:1056-1058, 1992
  3. George JN, el-Harake MA, Raskob GE. Chronic idiopathic thrombocytopenic purpura. N Engl J Med 331: 1207-1211, 1994
  4. Bussel JB, Graziano JN, Kimberly RP, et al. Intravenous anti-D treatment of immune thrombocytopenic purpura: analysis of efficacy, toxicity, and mechanism of effect. Blood 77: 1884- 1893, 1991
  5. Salama A, Kiefel V, Amberg R, Mueller-Eckhart C. Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies [anti- Rho(d)]. Blut 49:29, 1984
  6. Bussel JB, Kaufmann CP, Ware RE, Woloski BMR. Do the acute platelet responses of patients with immune thrombocytopenic purpura (ITP) to IV anti-D and to IV gammaglobulin predict response to subsequent splenectomy? Am J Hematol 67:27-33, 2000
  7. Moser AM, Shalev H, Kapelushnik J. Anti-D exerts a very early response in childhood acute idiopathic thrombocytopenic purpura. Pediatr Hematol Oncol 19:407-11, 2002
  8. Ünsal Ç, Gürkan E, Güvenç B ve ark. Kronik idiyopatik Trombositopenik Purpurada Anti-D ve intravenöz immünglobulin Tedavisi. Turk J Haematol 21: 27-32, 2004
  9. Newman GC, Novoa MV, Fodero EM, et al. A dose of 75 μg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 μg/kg/d in adults with immune thrombocytopenic purpura. Br J Haematol 112:1076± 1078, 2001
  10. Scaradavou A. Splenectomy-sparing, long-term maintenance with anti-D for chronic immune thrombocytopenic purpura: The New York hospital experience. Semin Hematol 37: 42-4, 2000.